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DRUG:

Cervarix (recombinant human papillomavirus bivalent vaccine)

i
Other names: human papillomavirus (types 6, 18) L1 virus-like particle vaccine, human papillomavirus 16/18 L1 AS04 virus-like particle cervical cancer vaccine, GSK-580299, MEDI 517, HPV-16/18 VLP AS04 vaccine, MEDI-517 HPV-16/18 VLP AS04 vaccine, GSK 580299, GSK580299
Associations
Company:
GSK, Japan Vaccine
Drug class:
Immunostimulant
Related drugs:
Associations
3ms
Effectiveness of HPV vaccine as part of national immunization program for preventing HPV infection in Thai schoolgirls after seven years post-vaccination. (PubMed, Hum Vaccin Immunother)
Between May and June 2023, 211 grade 12 female students from Ayutthaya, who received the two-dose bivalent HPV vaccine CERVARIXⓇ (HPV types 16 and 18), and 376 grade 12 students from Nakhon Pathom who did not receive the HPV vaccine, were enrolled...Our findings indicated that the bivalent HPV vaccine does not provide cross-protection against non-vaccine HPV types. Prioritizing vaccines with the highest coverage of HR-HPV types, such as the nonavalent HPV vaccine, is crucial to effectively prevent a broader range of HR-HPV infections under the NIP.
Journal
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cobas® HPV test
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Cervarix (recombinant human papillomavirus bivalent vaccine)
7ms
HVRRICANE: Safety and Effects of Using Prime-boost HIVIS DNA and MVA-CMDR Vaccine Regimens With or Without Toll-like Receptor 4 Agonist on HIV Reservoirs in Perinatally HIV Infected Children and Youth (clinicaltrials.gov)
P1, N=25, Active, not recruiting, Henry M. Jackson Foundation for the Advancement of Military Medicine | Recruiting --> Active, not recruiting | Trial completion date: Oct 2023 --> Feb 2025
Enrollment closed • Trial completion date
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CD4 (CD4 Molecule)
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Cervarix (recombinant human papillomavirus bivalent vaccine)
8ms
Enrollment change
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Cervarix (recombinant human papillomavirus bivalent vaccine)
11ms
HPV vaccines induce trained immunity and modulate pro-inflammatory cytokine expression in response to secondary Toll-like receptor stimulations. (PubMed, Microbiol Immunol)
In this work, we explored the innate immune responses and trained immunity caused by two HPV vaccines, Cervarix and Gardasil. Moreover, Gardasil injection into mice resulted in enhanced TNF-α production in sera following secondary TLR stimulation. Our findings suggest that HPV vaccinations have the ability to induce trained immunity that modulate TLR ligand responses.
Journal • IO biomarker
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IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL1B (Interleukin 1, beta) • IFNB1 (Interferon Beta 1)
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IL6 expression
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Cervarix (recombinant human papillomavirus bivalent vaccine) • Gardasil (quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine)
1year
The efficacy of human papillomavirus vaccination in the prevention of recurrence of severe cervical lesions. (PubMed, Ceska Gynekol)
Adjuvant HPV vaccination in the setting of surgical treatment for cervical precancerous lesion is significantly associated with a reduced risk of recurrence. HPV vaccination should be strongly considered as adjuvant therapy, especially in young patients undergoing conisation for a severe cervical lesion.
Journal
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Cervarix (recombinant human papillomavirus bivalent vaccine) • Gardasil 9 (human papillomavirus 9-valent vaccine, recombinant)
over1year
Impact and Cost-Effectiveness of Alternative Human Papillomavirus Vaccines for Preadolescent Girls in Mozambique: A Modelling Study. (PubMed, Vaccines (Basel))
This study evaluated the health and economic impact of the current HPV vaccine (GARDASIL hereafter referred to as GARDASIL-4) and two other vaccines (CECOLIN and CERVARIX) that could be used in the future. At a willingness-to-pay (WTP) threshold set at 35% of Gross Domestic Product (GDP) per capita, HPV vaccination is cost-effective in Mozambique. The optimal vaccine choice depends on cross-protection assumptions.
Journal • HEOR • Cost-effectiveness • Cost effectiveness
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Cecolin (recombinant human papillomavirus bivalent (types 16, 18) vaccine (Escherichia coli)) • Cervarix (recombinant human papillomavirus bivalent vaccine) • Gardasil (quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine)
over1year
Impact, cost-effectiveness, and budget implications of HPV vaccination in Kenya: A modelling study. (PubMed, Vaccine)
HPV vaccination for girls is highly cost-effective in Kenya. Compared to GARDASIL-4, alternative products could provide similar or greater health benefits at lower net costs. Substantial government funding will be required to reach and sustain coverage targets as Kenya graduates from Gavi support. A single dose strategy is likely to have similar benefits for less cost.
Journal • HEOR • Cost-effectiveness • Cost effectiveness
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Cecolin (recombinant human papillomavirus bivalent (types 16, 18) vaccine (Escherichia coli)) • Cervarix (recombinant human papillomavirus bivalent vaccine) • Gardasil 9 (human papillomavirus 9-valent vaccine, recombinant)
2years
Genetic engineering of baculovirus-insect cell system to improve protein production. (PubMed, Front Bioeng Biotechnol)
To date, eleven BEVS-derived products have been approved for use, including four human vaccines [Cervarix against cervical cancer caused by human papillomavirus (HPV), Flublok and Flublok Quadrivalent against seasonal influenza, Nuvaxovid/Covovax against COVID-19], two human therapeutics [Provenge against prostate cancer and Glybera against hereditary lipoprotein lipase deficiency (LPLD)] and five veterinary vaccines (Porcilis Pesti, BAYOVAC CSF E2, Circumvent PCV, Ingelvac CircoFLEX and Porcilis PCV). As the demand for biotechnology increases, there has been a concomitant effort into optimizing yield, stability and protein glycosylation through genetic engineering and the manipulation of baculovirus vector and host cells. In this review, we summarize the strategies and technological advances of BEVS in recent years and explore how this will be used to inform the further development and application of this system.
Review • Journal
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LPL (Lipoprotein Lipase)
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Provenge (sipuleucel-T) • Cervarix (recombinant human papillomavirus bivalent vaccine)
almost3years
Relationship between Papillomavirus vaccine, vaginal microbiome, and local cytokine response: an exploratory research. (PubMed, Braz J Microbiol)
Vaginal microbiome is not altered following administration of the standard three-dose HPV-16/18 AS04-adjuvanted (Cervarix®) vaccine.
Journal
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IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • IL2 (Interleukin 2) • IL10 (Interleukin 10) • CSF2 (Colony stimulating factor 2) • IL13 (Interleukin 13) • IL4 (Interleukin 4)
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Cervarix (recombinant human papillomavirus bivalent vaccine)
over3years
Combination of human papillomaviruses L1 and L2 multiepitope constructs protects mice against tumor cells. (PubMed, Fundam Clin Pharmacol)
Three prophylactic vaccines (Cervarix, Gardasil, and Gardasil-9) were approved to provide immuno-protection against certain types of HPVs. Our data showed that two designed vaccine constructs harboring 8 L1 peptides or 7 L2 peptides, individually were highly conserved between all well-known HPV types. In addition, the combination of in silico/in vivo approaches indicated the potential ability of L1 and L2 polyepitope constructs for development of next generation prophylactic/therapeutic HPV vaccine.
Preclinical • Journal
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IFNG (Interferon, gamma) • IL10 (Interleukin 10) • TLR4 (Toll Like Receptor 4)
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Cervarix (recombinant human papillomavirus bivalent vaccine) • Gardasil 9 (human papillomavirus 9-valent vaccine, recombinant)