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GENE:

CEP55 (Centrosomal Protein 55)

News alerts, weekly reports and conference planners

Effects of CRISPR-Cas9-mediated CEP55 gene knockout on immune evasion mechanisms of liver cancer cells. (PubMed, Sci Rep)

Collectively, these findings indicate that CEP55 promotes liver cancer immune escape and malignant progression through modulation of STAT1-dependent PD-L1/MHC-I expression, oxidative stress, and immunosuppressive signaling. Targeting CEP55 may therefore represent a potential strategy to improve antitumor immune recognition in liver cancer.

2 days ago

Journal • PD(L)-1 Biomarker • IO biomarker

IFNG (Interferon, gamma) • IL10 (Interleukin 10) • GZMB (Granzyme B) • TGFB1 (Transforming Growth Factor Beta 1) • STAT1 (Signal Transducer And Activator Of Transcription 1) • CEP55 (Centrosomal Protein 55)

PD-L1 expression

Cytokinetic abscission failures in a polarized epithelium affect apical membrane size and cilia. (PubMed, Mol Biol Cell)

Remarkably, blocking apoptosis does not rescue but exacerbates the phenotypes: extra-large apical endfeet have further increased multiciliation, supernumerary centrosomes, and abnormal or multiple nuclei, although epithelial polarity is maintained. These findings elucidate the importance of proper abscission in maintaining polarized epithelial structure, and reveal that p53-mediated apoptosis is a crucial guardian of tissue architecture when cell division defects arise during development and disease.

2 days ago

Journal

CEP55 (Centrosomal Protein 55)

25d

Identification of potential key genes and molecular mechanisms of oral squamous cell carcinoma based on integrated bioinformatics approach. (PubMed, J Genet Eng Biotechnol)

Previous study shows KIF23 takes part in raising Cell Proliferation in Hepatocellular carcinoma cells and AURKA shows notable overexpression in cancer tissues, which indicates that KIF23 and AURKA showed promising character to become possible biomarkers for OSCC. Further analysis needed to justify the statement.

25 days ago

Journal

AURKA (Aurora kinase A) • CDC20 (Cell Division Cycle 20) • NCAPG (Non-SMC Condensin I Complex Subunit G) • ANLN (Anillin Actin Binding Protein) • CEP55 (Centrosomal Protein 55) • KIF23 (Kinesin Family Member 23)

Multi-dimensional integration of gene expression, protein evidence, and serum autoantibodies for diagnostic modeling in esophageal squamous cell carcinoma. (PubMed, Front Immunol)

The web-based diagnostic tool is accessible at https://linzou.shinyapps.io/ESCC_SVM_Model/. This multi-dimensional approach linking transcriptomic evidence, protein-level validation, and immunodiagnostic markers facilitated the development of a diagnostic model, which may hold promise for early detection of ESCC.

1 month ago

Journal

CEP55 (Centrosomal Protein 55) • KIF2C (Kinesin Family Member 2C)

2ms

CEP55 Drives Pancreatic Cancer Progression by Suppressing Ferroptosis. (PubMed, Biofactors)

Erastin, a ferroptosis inducer, enhanced ferroptosis in CEP55-deficient cells and counteracted the tumor-promoting effects of CEP55 overexpression. In vivo, CEP55 silencing reduced tumor growth and altered ferroptosis markers. Our findings establish CEP55 as a novel driver of PC progression via ferroptosis suppression, supporting its potential as both a prognostic biomarker and a therapeutic target for combination strategies aimed at overcoming PC resistance.

2 months ago

Journal

GPX4 (Glutathione Peroxidase 4) • NQO1 (NAD(P)H dehydrogenase, quinone 1) • SLC7A11 (Solute Carrier Family 7 Member 11) • CEP55 (Centrosomal Protein 55)

erastin

2ms

Telomere-based Risk Model for Prognosis Prediction in Clear Cell Renal Cell Carcinoma. (PubMed, Curr Med Chem)

This study identified six telomere-related genes with high expression and strong diagnostic value in ccRCC, highlighting their association with immune infiltration and potential as diagnostic and therapeutic targets.

2 months ago

Journal

MELK (Maternal Embryonic Leucine Zipper Kinase) • BUB1 (BUB1 Mitotic Checkpoint Serine/Threonine Kinase) • CEP55 (Centrosomal Protein 55)

2ms

CEP55 Promotes Prostate Cancer Progression via TPX2-Dependent Activation of AURKA/PI3K/AKT Signaling and Inhibition of Ferroptosis. (PubMed, J Biol Chem)

Our findings demonstrate that CEP55 enhances PCa progression by stimulating the TPX2/AURKA/PI3K/AKT signaling pathway and inhibiting ferroptosis. Targeting this axis may represent a potential therapeutic approach for PCa.

2 months ago

Journal

AURKA (Aurora kinase A) • GPX4 (Glutathione Peroxidase 4) • SLC7A11 (Solute Carrier Family 7 Member 11) • CEP55 (Centrosomal Protein 55)

2ms

Integrative Bioinformatics and Experimental Validation Establish CCNB1 as a Potential Biomarker for Diagnosis and Prognosis in Colorectal Cancer. (PubMed, Curr Issues Mol Biol)

In vitro, CCNB1 knockdown triggered cell cycle arrest, thereby suppressing the proliferation of colorectal cancer cells. This study validated CCNB1 as a dual-purpose biomarker for CRC diagnosis and favorable prognosis, highlighting its potential utility in clinical management.

2 months ago

Journal

TOP2A (DNA topoisomerase 2-alpha) • CDCA3 (Cell Division Cycle Associated 3) • CCNA2 (Cyclin A2) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) • CDC20 (Cell Division Cycle 20) • KIF11 (Kinesin Family Member 11) • MCM4 (Minichromosome Maintenance Complex Component 4) • CCNB1 (Cyclin B1) • CDK3 (Cyclin Dependent Kinase 3) • CEP55 (Centrosomal Protein 55) • CKS2 (CDC28 Protein Kinase Regulatory Subunit 2) • CRYAB (Crystallin Alpha B) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MMP3 (Matrix metallopeptidase 3) • TPM2 (Tropomyosin 2) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)

2ms

Discovery of Seven ROS-Sensitive Immune Checkpoints and 46 Ligands Mediating Immune Suppression Through T cell-APC Networks. (PubMed, J Cancer)

Our study delineates a comprehensive immune checkpoint-ligand network encompassing seven novel ICs and 46 associated ligands, providing mechanistic insight into Treg- and T cell-mediated immune regulation. This expanded IC landscape broadens the current repertoire of immune modulatory pathways and highlights new therapeutic opportunities across cancer, autoimmune disorders, infectious diseases, transplantation immunology, inflammatory conditions, and cardiovascular diseases.

2 months ago

Journal • IO biomarker

CD4 (CD4 Molecule) • FOXP3 (Forkhead Box P3) • CD200R1 (CD200 Receptor 1) • CD86 (CD86 Molecule) • CEP55 (Centrosomal Protein 55)

3ms

Differentially Expressed Genes Associated with the Development of Cervical Cancer. (PubMed, Int J Mol Sci)

The publicly available microarray datasets, including GSE39001, GSE9750, GSE7803, GSE6791, GSE63514, and GSE52903 in combination with bioinformatics database predictions, were used to identify differential expression genes, potential biomarkers, and therapeutic targets for cervical cancer; additionally, we undertook bioinformatic analysis to determine gene ontology and possible miRNA targets related to our DEGs...Interestingly, hub proteins KIF4A, NUSAP1, BUB1B, CEP55, DLGAP5, NCAPG, CDK1, MELK, KIF11, and KIF20A were found to be potentially regulated by several miRNAs, including miR-107, miR-124-3p, miR-147a, miR-16-5p, miR-34a-5p, miR-34c-5p, miR-126-3p, miR-10b-5p, miR-23b-3p, miR-200b-3p, miR-138-5p, miR-203a-3p, miR-214-3p, and let-7b-5p. The relationship between these genes highlights their potential as candidate biomarkers for further research in treatment, diagnosis, and prognosis.

3 months ago

Journal

TP53 (Tumor protein P53) • TOP2A (DNA topoisomerase 2-alpha) • RAD51 (RAD51 Homolog A) • MIR200B (MicroRNA 200b) • MIR34A (MicroRNA 34a-5p) • RAD51AP1 (RAD51 Associated Protein 1) • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • ELF3 (E74 Like ETS Transcription Factor 3) • FOXM1 (Forkhead Box M1) • MELK (Maternal Embryonic Leucine Zipper Kinase) • CDK1 (Cyclin-dependent kinase 1) • KIF11 (Kinesin Family Member 11) • MIR126 (MicroRNA 126) • MIR16 (MicroRNA 16) • MIR23b (MicroRNA 23b) • NCAPG (Non-SMC Condensin I Complex Subunit G) • PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2) • BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) • CEP55 (Centrosomal Protein 55) • CXCL14 (C-X-C Motif Chemokine Ligand 14) • E2F1 (E2F transcription factor 1) • KIF20A (Kinesin Family Member 20A) • KIF4A (Kinesin Family Member 4A) • MCM2 (Minichromosome maintenance complex component 2) • MCM5 (Minichromosome Maintenance Complex Component 5) • MIR10B (MicroRNA 10b) • MIR138 (MicroRNA 138) • MIR203A (MicroRNA 203a) • MIR214 (MicroRNA 214) • MIRLET7B (MicroRNA Let-7b) • RELA (RELA Proto-Oncogene) • RFC4 (Replication Factor C Subunit 4) • MIR124-3 (MicroRNA 124-3)

4ms

CBX2 promoted oral squamous cell carcinoma via increasing CEP55/NF-κB/METTL3/SHP2 signaling induced metastasis/proliferation and angiogenesis. (PubMed, Sci Rep)

Western blot and tube formation assay results showed that CBX2 knockdown, NF-κB activation, METTL3 inhibition, METTL3 overexpression, and SHP2 inhibition all inhibited or promoted angiogenesis. CBX2 promoted oral squamous cell carcinoma via increasing CEP55/NF-κB/METTL3/SHP2 signaling, leading to metastasis, proliferation, and angiogenesis.

4 months ago

Journal

TGFB1 (Transforming Growth Factor Beta 1) • SNAI2 (Snail Family Transcriptional Repressor 2) • CBX2 (Chromobox 2) • CEP55 (Centrosomal Protein 55) • METTL3 (Methyltransferase Like 3)