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GENE:

CEP55 (Centrosomal Protein 55)

News alerts, weekly reports and conference planners

CEP55 Drives Pancreatic Cancer Progression by Suppressing Ferroptosis. (PubMed, Biofactors)

Erastin, a ferroptosis inducer, enhanced ferroptosis in CEP55-deficient cells and counteracted the tumor-promoting effects of CEP55 overexpression. In vivo, CEP55 silencing reduced tumor growth and altered ferroptosis markers. Our findings establish CEP55 as a novel driver of PC progression via ferroptosis suppression, supporting its potential as both a prognostic biomarker and a therapeutic target for combination strategies aimed at overcoming PC resistance.

9 days ago

Journal

GPX4 (Glutathione Peroxidase 4) • NQO1 (NAD(P)H dehydrogenase, quinone 1) • SLC7A11 (Solute Carrier Family 7 Member 11) • CEP55 (Centrosomal Protein 55)

erastin

22d

Telomere-based Risk Model for Prognosis Prediction in Clear Cell Renal Cell Carcinoma. (PubMed, Curr Med Chem)

This study identified six telomere-related genes with high expression and strong diagnostic value in ccRCC, highlighting their association with immune infiltration and potential as diagnostic and therapeutic targets.

22 days ago

Journal

MELK (Maternal Embryonic Leucine Zipper Kinase) • BUB1 (BUB1 Mitotic Checkpoint Serine/Threonine Kinase) • CEP55 (Centrosomal Protein 55)

23d

CEP55 Promotes Prostate Cancer Progression via TPX2-Dependent Activation of AURKA/PI3K/AKT Signaling and Inhibition of Ferroptosis. (PubMed, J Biol Chem)

Our findings demonstrate that CEP55 enhances PCa progression by stimulating the TPX2/AURKA/PI3K/AKT signaling pathway and inhibiting ferroptosis. Targeting this axis may represent a potential therapeutic approach for PCa.

23 days ago

Journal

AURKA (Aurora kinase A) • GPX4 (Glutathione Peroxidase 4) • SLC7A11 (Solute Carrier Family 7 Member 11) • CEP55 (Centrosomal Protein 55)

24d

Integrative Bioinformatics and Experimental Validation Establish CCNB1 as a Potential Biomarker for Diagnosis and Prognosis in Colorectal Cancer. (PubMed, Curr Issues Mol Biol)

In vitro, CCNB1 knockdown triggered cell cycle arrest, thereby suppressing the proliferation of colorectal cancer cells. This study validated CCNB1 as a dual-purpose biomarker for CRC diagnosis and favorable prognosis, highlighting its potential utility in clinical management.

24 days ago

Journal

TOP2A (DNA topoisomerase 2-alpha) • CDCA3 (Cell Division Cycle Associated 3) • CCNA2 (Cyclin A2) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) • CDC20 (Cell Division Cycle 20) • KIF11 (Kinesin Family Member 11) • MCM4 (Minichromosome Maintenance Complex Component 4) • CCNB1 (Cyclin B1) • CDK3 (Cyclin Dependent Kinase 3) • CEP55 (Centrosomal Protein 55) • CKS2 (CDC28 Protein Kinase Regulatory Subunit 2) • CRYAB (Crystallin Alpha B) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MMP3 (Matrix metallopeptidase 3) • TPM2 (Tropomyosin 2) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)

28d

Discovery of Seven ROS-Sensitive Immune Checkpoints and 46 Ligands Mediating Immune Suppression Through T cell-APC Networks. (PubMed, J Cancer)

Our study delineates a comprehensive immune checkpoint-ligand network encompassing seven novel ICs and 46 associated ligands, providing mechanistic insight into Treg- and T cell-mediated immune regulation. This expanded IC landscape broadens the current repertoire of immune modulatory pathways and highlights new therapeutic opportunities across cancer, autoimmune disorders, infectious diseases, transplantation immunology, inflammatory conditions, and cardiovascular diseases.

28 days ago

Journal • IO biomarker

CD4 (CD4 Molecule) • FOXP3 (Forkhead Box P3) • CD200R1 (CD200 Receptor 1) • CD86 (CD86 Molecule) • CEP55 (Centrosomal Protein 55)

Differentially Expressed Genes Associated with the Development of Cervical Cancer. (PubMed, Int J Mol Sci)

The publicly available microarray datasets, including GSE39001, GSE9750, GSE7803, GSE6791, GSE63514, and GSE52903 in combination with bioinformatics database predictions, were used to identify differential expression genes, potential biomarkers, and therapeutic targets for cervical cancer; additionally, we undertook bioinformatic analysis to determine gene ontology and possible miRNA targets related to our DEGs...Interestingly, hub proteins KIF4A, NUSAP1, BUB1B, CEP55, DLGAP5, NCAPG, CDK1, MELK, KIF11, and KIF20A were found to be potentially regulated by several miRNAs, including miR-107, miR-124-3p, miR-147a, miR-16-5p, miR-34a-5p, miR-34c-5p, miR-126-3p, miR-10b-5p, miR-23b-3p, miR-200b-3p, miR-138-5p, miR-203a-3p, miR-214-3p, and let-7b-5p. The relationship between these genes highlights their potential as candidate biomarkers for further research in treatment, diagnosis, and prognosis.

1 month ago

Journal

TP53 (Tumor protein P53) • TOP2A (DNA topoisomerase 2-alpha) • RAD51 (RAD51 Homolog A) • MIR200B (MicroRNA 200b) • MIR34A (MicroRNA 34a-5p) • RAD51AP1 (RAD51 Associated Protein 1) • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • ELF3 (E74 Like ETS Transcription Factor 3) • FOXM1 (Forkhead Box M1) • MELK (Maternal Embryonic Leucine Zipper Kinase) • CDK1 (Cyclin-dependent kinase 1) • KIF11 (Kinesin Family Member 11) • MIR126 (MicroRNA 126) • MIR16 (MicroRNA 16) • MIR23b (MicroRNA 23b) • NCAPG (Non-SMC Condensin I Complex Subunit G) • PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2) • BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) • CEP55 (Centrosomal Protein 55) • CXCL14 (C-X-C Motif Chemokine Ligand 14) • E2F1 (E2F transcription factor 1) • KIF20A (Kinesin Family Member 20A) • KIF4A (Kinesin Family Member 4A) • MCM2 (Minichromosome maintenance complex component 2) • MCM5 (Minichromosome Maintenance Complex Component 5) • MIR10B (MicroRNA 10b) • MIR138 (MicroRNA 138) • MIR203A (MicroRNA 203a) • MIR214 (MicroRNA 214) • MIRLET7B (MicroRNA Let-7b) • RELA (RELA Proto-Oncogene) • RFC4 (Replication Factor C Subunit 4) • MIR124-3 (MicroRNA 124-3)

2ms

CBX2 promoted oral squamous cell carcinoma via increasing CEP55/NF-κB/METTL3/SHP2 signaling induced metastasis/proliferation and angiogenesis. (PubMed, Sci Rep)

Western blot and tube formation assay results showed that CBX2 knockdown, NF-κB activation, METTL3 inhibition, METTL3 overexpression, and SHP2 inhibition all inhibited or promoted angiogenesis. CBX2 promoted oral squamous cell carcinoma via increasing CEP55/NF-κB/METTL3/SHP2 signaling, leading to metastasis, proliferation, and angiogenesis.

2 months ago

Journal

TGFB1 (Transforming Growth Factor Beta 1) • SNAI2 (Snail Family Transcriptional Repressor 2) • CBX2 (Chromobox 2) • CEP55 (Centrosomal Protein 55) • METTL3 (Methyltransferase Like 3)

4ms

Comprehensive Analysis Identifies Tumor Mutation Burden-associated Genes ASPM and KIF11 as Novel Biomarkers for Adrenocortical Carcinoma. (PubMed, Curr Cancer Drug Targets)

A total of eight candidate TMB-related prognostic genes (including ASPM, BIRC5, BUB1, CDC20, CDCA5, CEP55, KIF11, and TPX2) for ACC patients were identified. Preliminary experimental verification revealed that ASPM and KIF11 could promote the proliferation of ACC cells and ACC tumor growth in vivo.

4 months ago

Journal • Tumor mutational burden • PD(L)-1 Biomarker • IO biomarker

PD-L1 (Programmed death ligand 1) • TMB (Tumor Mutational Burden) • BIRC5 (Baculoviral IAP repeat containing 5) • CDC20 (Cell Division Cycle 20) • KIF11 (Kinesin Family Member 11) • BUB1 (BUB1 Mitotic Checkpoint Serine/Threonine Kinase) • CEP55 (Centrosomal Protein 55)

PD-L1 expression • TMB-H • TMB-L

5ms

Oncogenic H-Ras Reprograms Madin-Darby Canine Kidney (MDCK) Cell-Derived Midbody Remnant Proteome Following Epithelial-Mesenchymal Transition. (PubMed, Proteomics)

We identify several mesenchymal-enriched networks in MBRs associated with focal adhesion, cell matrix, kinase activity, and cell shape/organization, while epithelial-derived MBRs show enriched networks predominantly associated with mitochondrial (processing/transport), midbody, and plasma membrane annotation. Our study sheds light on the proteome architecture of MBRs following oncogenic H-Ras-induced EMT in cell transformation: collectively, our data informs ongoing efforts to delineate oncogenic drivers of cancer initiation, progression, and metastasis.

5 months ago

Journal

HRAS (Harvey rat sarcoma viral oncogene homolog) • CDH1 (Cadherin 1) • CD73 (5'-Nucleotidase Ecto) • PLK1 (Polo Like Kinase 1) • EPCAM (Epithelial cell adhesion molecule) • NT5E (5'-Nucleotidase Ecto) • CDH2 (Cadherin 2) • CEP55 (Centrosomal Protein 55) • KIF23 (Kinesin Family Member 23) • KIF4A (Kinesin Family Member 4A) • MMP14 (Matrix Metallopeptidase 14)

5ms

Nodal Spread Prediction in Human Oral Tongue Squamous Cell Carcinoma Using a Cancer-Testis Antigen Genes Signature. (PubMed, Int J Mol Sci)

We present a proof-of-concept CTA-based genetic diagnostic tool capable of discriminating nodal involvement in oral tongue cancer. This approach may reduce unnecessary neck dissections, minimizing surgical morbidity.

5 months ago

Journal

MAGEA3 (MAGE Family Member A3) • CEP55 (Centrosomal Protein 55)

5ms

Cytokinetic abscission failures in a polarized epithelium affect apical membrane size and cilia. (PubMed, bioRxiv)

However, blocking apoptosis does not rescue but exacerbates the phenotypes: extra-large apical endfeet have further increased multi-ciliation, supernumerary centrosomes, and abnormal or multiple nuclei. These findings show the importance of proper abscission in a polarized epithelium to maintain epithelial structure, and the need for p53-mediated apoptosis to protect the tissue in the face of stochastic abscission failures.

5 months ago

Journal

CEP55 (Centrosomal Protein 55)