^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    CENPU (Centromere Protein U)

    i
    Other names: CENPU, Centromere Protein U, KLIP1, PBIP1, Polo-Box-Interacting Protein 1, CENP-50, CENP-U, MLF1IP, Interphase Centromere Complex Protein 24, Centromere Protein Of 50 KDa, MLF1 Interacting Protein, KSHV Latent Nuclear Antigen Interacting Protein 1, KSHV Latent Nuclear Antigen-Interacting Protein 1, MLF1-Interacting Protein, CENPU50, CENP50, ICEN24
    Associations

    News

    Trials
    3ms
    Advances in glycolysis research in gastric cancer: molecular mechanisms, regulatory networks, and therapeutic potential. (PubMed, Front Oncol)
    It also discusses the prognostic value of glycolysis-related genes and their potential as therapeutic targets, including the application of natural compounds and small-molecule inhibitors in anti-glycolytic strategies. These findings provide valuable insights into the metabolic mechanisms underlying gastric cancer and highlight the potential for developing metabolism-targeted therapies.
    Review • Journal
    |
    CD73 (5'-Nucleotidase Ecto) • SALL4 (Spalt Like Transcription Factor 4) • CENPU (Centromere Protein U)
    5ms
    CENPU promotes tumorigenesis and stem cell properties in triple‑negative breast cancer by suppressing lysosomal furin degradation. (PubMed, Int J Mol Med)
    The findings of the present study revealed that CENPU serves a critical role in furin‑mediated signaling responsible for tumorigenesis. Therefore, CENPU may be a novel molecular target in TNBC.
    Journal
    |
    CENPU (Centromere Protein U)
    12ms
    DPHC from Alpinia officinarum Hance specifically modulates the function of CENPU in the cell cycle and apoptosis to ameliorate hepatocellular carcinoma. (PubMed, J Ethnopharmacol)
    DPHC from A. officinarum specifically modulates the function of CENPU in the cell cycle and apoptosis to ameliorate HCC. Our study revealed the anti-HCC effect and underlying mechanism of DPHC, offering new insights and potential targets for HCC treatment.
    Journal
    |
    CCND1 (Cyclin D1) • CDK4 (Cyclin-dependent kinase 4) • CASP3 (Caspase 3) • CASP9 (Caspase 9) • CDK1 (Cyclin-dependent kinase 1) • CENPU (Centromere Protein U) • E2F1 (E2F transcription factor 1)
    12ms
    Centromere protein U mediates the ubiquitination and degradation of RPS3 to facilitate temozolomide resistance in glioblastoma. (PubMed, Drug Resist Updat)
    Our study identified CENPU as a novel key gene mediating TMZ resistance and elucidated its molecular mechanisms, providing a new target to overcome TMZ resistance in GBM.
    Journal
    |
    RAD51 (RAD51 Homolog A) • CENPU (Centromere Protein U) • E2F1 (E2F transcription factor 1)
    |
    temozolomide
    over1year
    Overexpression of CENPU promotes cancer growth and metastasis and is associated with poor survival in patients with nasopharyngeal carcinoma. (PubMed, Transl Cancer Res)
    Mechanistic studies confirmed that CENPU increased the activation of the ERK1/2 and p38 signaling pathways by suppressing the expression of DUSP6. CENPU acts as an oncogene in NPC by interacting with DUSP6, and may represent a promising prognostic biomarker for patients with NPC.
    Journal
    |
    DUSP6 (Dual specificity phosphatase 6) • CENPU (Centromere Protein U)
    almost3years
    Knockdown of CENPU inhibits cervical cancer cell migration and stemness through the FOXM1/Wnt/β-catenin pathway. (PubMed, Tissue Cell)
    In vivo study demonstrated that CENPU knockdown inhibited the growth of CC, indicated by reduced sizes and volumes of CC. In summary, our results suggested that knockdown of CENPU inhibited CC migration and stemness through the FOXM1/Wnt/β-catenin pathway.
    Journal
    |
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • POU5F1 (POU Class 5 Homeobox 1) • FOXM1 (Forkhead Box M1) • NANOG (Nanog Homeobox) • CENPU (Centromere Protein U) • MMP7 (Matrix metallopeptidase 7)
    |
    MYC expression • POU5F1 expression
    almost3years
    A five-gene expression signature of centromeric proteins with prognostic value in lung adenocarcinoma. (PubMed, Transl Cancer Res)
    A total of 441 hub genes coexpressed with the 5 CENPs were identified. CENPF, CENPU, CENPM, CENPH, and CENPW have prognostic values and may be potential targets for LUAD treatment.
    Journal
    |
    CENPU (Centromere Protein U)
    3years
    Prognostic Value of the Expression of Myeloid Leukemia Factor 1-Interacting Protein in Gastric Cancer and Its Regulatory Role in Tumor Progression (PubMed, Sichuan Da Xue Xue Bao Yi Xue Ban)
    Subcutaneous tumor xenograft experiment in nude mice showed that knocking down MLF1 IP gene significantly inhibited tumor growth. Increased expression of MLF1IP in gastric cancer tissue, which may be involved in the malignant activities of proliferation, migration, and invasion of gastric cancer cells, has a certain predictive value for poor prognosis.
    Journal
    |
    CEACAM5 (CEA Cell Adhesion Molecule 5) • CA 19-9 (Cancer antigen 19-9) • CENPU (Centromere Protein U)
    over3years
    Centromere protein U is highly expressed in colorectal cancer and associated with a poor long-term prognosis (PubMed, Nan Fang Yi Ke Da Xue Xue Bao)
    CENPU is highly expressed in colorectal cancer tissues in closely correlation with tumor progression and may serve as a potential biomarker for evaluating the long-term prognosis of colorectal cancer patients.
    Retrospective data • Journal
    |
    VEGFC (Vascular Endothelial Growth Factor C) • CENPU (Centromere Protein U)
    over3years
    A positive feedback loop of CENPU/E2F6/E2F1 facilitates proliferation and metastasis via ubiquitination of E2F6 in hepatocellular carcinoma. (PubMed, Int J Biol Sci)
    E2F1 directly binds to the CENPU promoter and increases the transcription of CENPU, thereby forming a positive regulatory loop. Collectively, our findings indicate a crucial role for CENPU in E2F1-mediated signalling for cell cycle progression and reveal a role for CENPU as a predictive biomarker and therapeutic target for HCC patients.
    Journal
    |
    CENPU (Centromere Protein U) • E2F1 (E2F transcription factor 1)
    over3years
    Identification and characterization of sex-dependent gene expression profile in glioblastoma. (PubMed, Neuropathology)
    Among these key genes, interestingly, ECT2 was associated with increased an survival rate for female patients, whileTNFSF13B could be regarded as a potential marker of poor prognosis in male patients. These results suggested that sex differences in patients may be attributed to the heterogeneous gene activity, which might influence the oncogenesis and the outcomes of GBM.
    Journal • Gene Expression Profile
    |
    CXCR4 (Chemokine (C-X-C motif) receptor 4) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • CD44 (CD44 Molecule) • TYMS (Thymidylate Synthetase) • AURKA (Aurora kinase A) • CSPG4 (Chondroitin Sulfate Proteoglycan 4) • CCL2 (Chemokine (C-C motif) ligand 2) • FCGR2A (Fc fragment of IgG receptor IIa) • TNFSF13B (TNF Superfamily Member 13b) • CDK1 (Cyclin-dependent kinase 1) • IGFBP3 (Insulin-like growth factor binding protein 3) • CENPU (Centromere Protein U) • FBXO5 (F-Box Protein 5)
    over3years
    Comprehensive Analysis of Centromere Protein Family Member Genes in Lung Adenocarcinoma. (PubMed, Crit Rev Eukaryot Gene Expr)
    The expression changes of these eight genes in the Gene Expression Omnibus were also highly expressed in LUAD-compared with normal tissues, which confirmed the analysis in the Gene Expression Profiling Interactive Analysis (GEPIA) database. To sum up, we aimed to provide new biomarkers.
    Journal
    |
    MSI (Microsatellite instability) • CENPI (Centromere Protein I) • CENPA (Centromere protein A) • CENPF (Centromere Protein F) • CENPU (Centromere Protein U) • CENPW (Centromere Protein W)