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    GENE:

    CELF4 (CUGBP Elav-Like Family Member 4)

    i
    Other names: CELF4, CUGBP Elav-Like Family Member 4, BRUNOL4, CUG-BP- And ETR-3-Like Factor 4, Bruno-Like Protein 4, CELF-4, Bruno (Drosophila) -Like 4, RNA Binding Protein, Bruno-Like 4, RNA Binding Protein (Drosophila), Bruno-Like 4, RNA Binding Protein, CUGBP, Elav-Like Family Member 4, LYST-Interacting Protein LIP9, RNA-Binding Protein BRUNOL-4, RNA-Binding Protein BRUNOL4
    Associations

    News

    Trials
    2ms
    CDO1 and CELF4 methylation assay as the dominant predictor of endometrial cancer: A cohort analysis across pre- and post-menopausal cohorts. (PubMed, Gynecol Oncol)
    The non-invasive CDO1 and CELF4 methylation assay demonstrates high diagnostic accuracy for EC and represents a promising tool for non-invasive diagnosis and triage, particularly in women at high risk for EC and those with early-stage disease.
    Journal
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    CELF4 (CUGBP Elav-Like Family Member 4)
    2ms
    DNA Methylation of Combined Gene Markers in Cytological Specimens for Endometrial Cancer Screening. (PubMed, Diagn Cytopathol)
    Integrating DNA methylation markers into ECT offers a non-invasive and highly accurate approach to EC screening. This model's high diagnostic accuracy and reliability have the potential to transform EC diagnosis, reducing reliance on invasive procedures and improving clinical management.
    Journal
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    CELF4 (CUGBP Elav-Like Family Member 4)
    2ms
    Clinical Validation of DNA Methylation Detection in Cervical Exfoliated Cells for Endometrial Cancer in Women with Suspected Lesions. (PubMed, Diagnostics (Basel))
    The combination with TVS further enhances sensitivity and NPV, offering a simple and non-invasive triage strategy for patients with suspected endometrial lesions. This study was registered in China Clinical Trial Registry (ChiCTR2200055991) on 30 January 2023.
    Journal
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    CDO1 (Cysteine Dioxygenase Type 1) • CELF4 (CUGBP Elav-Like Family Member 4)
    7ms
    Prospective Evaluation of Cervical Scrapings CDO1 and CELF4 Methylation (epiHERA®) Assay in Detection of Endometrial Cancer. (PubMed, Cancers (Basel))
    It can act as a triage to reduce invasive endometrial assessment. All false-positive cases were related to neoplastic processes in the genital tract, indicating that it may be useful for detecting cancer early, before histological change is evident.
    Journal
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    CELF4 (CUGBP Elav-Like Family Member 4)
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    epiHERA™
    9ms
    CircFLNB upregulated by chemotherapy via alternative splicing suppresses the progression of colorectal cancer. (PubMed, Cancer Lett)
    A patient prognosis model based on circFLNB expression levels can effectively predict the prognosis of CRC patients. Our research demonstrated that QKI- and CELF4- dependent alternative splicing induced by chemotherapy promotes circFLNB biogenesis, which inhibits CRC tumorigenesis via binding with miR-3127-3p to regulate the MOB1B/Hippo pathway.
    Journal
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    CELF4 (CUGBP Elav-Like Family Member 4)
    9ms
    CUGBP Elav-like family member 4 promotes cardiac remodeling through Inhibition of FMO2. (PubMed, BMC Cardiovasc Disord)
    Our study delineates that decreased CELF4 retards cardiac fibrosis and HF via interaction with FMO2 and suppression of Smad2/3 signaling. Inhibition of CELF4 may become a potential therapy target for cardiac fibrosis and HF.
    Journal
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    TGFB1 (Transforming Growth Factor Beta 1) • CELF4 (CUGBP Elav-Like Family Member 4)
    12ms
    DNA methylation detection is a significant biomarker for screening endometrial cancer in premenopausal women with abnormal uterine bleeding. (PubMed, Int J Gynecol Cancer)
    In premenopausal women with abnormal uterine bleeding, the clinical efficacy of DNA (CDO1m/CELF4m) methylation detection in exfoliated cervical cells for endometrial cancer screening was better than that of other noninvasive clinical indicators. In addition, dual gene methylation combined with BMI or endometrial thickness was a good predictor of endometrial cancer screening.
    Journal
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    CDO1 (Cysteine Dioxygenase Type 1) • CELF4 (CUGBP Elav-Like Family Member 4)
    12ms
    Pharmacogenomics in pediatric oncology patients with solid tumors related to chemotherapy-induced toxicity: a systematic review. (PubMed, Crit Rev Oncol Hematol)
    For methotrexate, the genes ABCC2, MTHFR, and SXR were associated with myelosuppression and hepatotoxicity...This review highlights the complexity and variability of pharmacogenomic associations with chemotherapy-induced toxicities in pediatric oncology. While certain genetic variants show associations with specific toxicities, larger multinational/center studies are needed to strengthen the associations and improve clinical guidelines.
    Review • Journal
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    ERCC2 (Excision repair cross-complementation group 2) • GSTP1 (Glutathione S-transferase pi 1) • MTHFR (Methylenetetrahydrofolate Reductase) • ABCC2 (ATP Binding Cassette Subfamily C Member 2) • ABCB4 (ATP Binding Cassette Subfamily B Member 4) • ABCC3 (ATP Binding Cassette Subfamily C Member 3) • GSTM1 (Glutathione S-transferase mu 1) • HAS3 (Hyaluronan Synthase 3) • RARG (Retinoic Acid Receptor Gamma) • GSTT1 (Glutathione S-transferase theta 1) • SLC22A2 (Solute Carrier Family 22 Member 2) • SLC28A3 (Solute Carrier Family 28 Member 3) • CELF4 (CUGBP Elav-Like Family Member 4) • COMT (Catechol-O-Methyltransferase)
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    methotrexate
    over1year
    Disease characteristics and clinical specific survival prediction of spinal ependymoma: a genetic and population-based study. (PubMed, Front Neurol)
    Previous studies have demonstrated that CELF4 may play a pivotal role in the pathogenesis of SP-EP. Furthermore, this study developed and validated a prognostic prediction model in the form of a nomogram utilizing the SEER database, enabling clinicians to accurately assess treatment risks and benefits, thereby enhancing personalized therapeutic strategies and prognosis predictions.
    Journal
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    CELF4 (CUGBP Elav-Like Family Member 4)
    over1year
    Combination of circulating tumor cells, lncRNAs and DNA methylation for the diagnosis of endometrial carcinoma. (PubMed, Oncol Lett)
    The positive rates of the methylated genes CDO1 and CELF4 were 20% (7/35) and 5.71% (2/35), and the P-values of the comparisons between the EC and NO-EC groups were 0.1748 and 0.5004, respectively; the AUC values were 0.6000 and 0.5286. Furthermore, the combination of CTCs, and lncRNAs RP4-616B8.5, RP11-389G6.3 and CTD-2377D24.6 exhibited high performance in the detection of EC (AUC=0.9375).
    Journal • Circulating tumor cells • Epigenetic controller • Tumor cell
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    CDO1 (Cysteine Dioxygenase Type 1) • CELF4 (CUGBP Elav-Like Family Member 4)
    over1year
    CELF4 (rs1786814) gene polymorphism and speckle-tracking Echocardiography for cardiovascular complications in childhood cancer survivors. (PubMed, Pediatr Res)
    Early detection of anthracycline-related cardiotoxicity in childhood cancer survivors (CCS) after finishing chemotherapy. CLEF4 (rs1786814) GG variant is more significant in CCS exposed to high-dose anthracycline. GLPS holds promise as an early predictor of late left ventricular dysfunction and subclinical cardiotoxicity in CCS.
    Journal
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    CELF4 (CUGBP Elav-Like Family Member 4)
    over1year
    DNA methylation detection is a significant biomarker for screening endometrial cancer in premenopausal women with abnormal uterine bleeding. (PubMed, Int J Gynecol Cancer)
    In premenopausal women with abnormal uterine bleeding, the clinical efficacy of DNA (CDO1m/CELF4m) methylation detection in exfoliated cervical cells for endometrial cancer screening was better than that of other noninvasive clinical indicators. In addition, dual gene methylation combined with BMI or endometrial thickness was a good predictor of endometrial cancer screening.
    Journal • Epigenetic controller
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    CDO1 (Cysteine Dioxygenase Type 1) • CELF4 (CUGBP Elav-Like Family Member 4)