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    GENE:

    CELF4 (CUGBP Elav-Like Family Member 4)

    i
    Other names: CELF4, CUGBP Elav-Like Family Member 4, BRUNOL4, CUG-BP- And ETR-3-Like Factor 4, Bruno-Like Protein 4, CELF-4, Bruno (Drosophila) -Like 4, RNA Binding Protein, Bruno-Like 4, RNA Binding Protein (Drosophila), Bruno-Like 4, RNA Binding Protein, CUGBP, Elav-Like Family Member 4, LYST-Interacting Protein LIP9, RNA-Binding Protein BRUNOL-4, RNA-Binding Protein BRUNOL4
    Associations

    News

    Trials
    3ms
    Prospective Evaluation of Cervical Scrapings CDO1 and CELF4 Methylation (epiHERA®) Assay in Detection of Endometrial Cancer. (PubMed, Cancers (Basel))
    It can act as a triage to reduce invasive endometrial assessment. All false-positive cases were related to neoplastic processes in the genital tract, indicating that it may be useful for detecting cancer early, before histological change is evident.
    Journal
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    CELF4 (CUGBP Elav-Like Family Member 4)
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    epiHERA™
    5ms
    CircFLNB upregulated by chemotherapy via alternative splicing suppresses the progression of colorectal cancer. (PubMed, Cancer Lett)
    A patient prognosis model based on circFLNB expression levels can effectively predict the prognosis of CRC patients. Our research demonstrated that QKI- and CELF4- dependent alternative splicing induced by chemotherapy promotes circFLNB biogenesis, which inhibits CRC tumorigenesis via binding with miR-3127-3p to regulate the MOB1B/Hippo pathway.
    Journal
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    CELF4 (CUGBP Elav-Like Family Member 4)
    6ms
    CUGBP Elav-like family member 4 promotes cardiac remodeling through Inhibition of FMO2. (PubMed, BMC Cardiovasc Disord)
    Our study delineates that decreased CELF4 retards cardiac fibrosis and HF via interaction with FMO2 and suppression of Smad2/3 signaling. Inhibition of CELF4 may become a potential therapy target for cardiac fibrosis and HF.
    Journal
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    TGFB1 (Transforming Growth Factor Beta 1) • CELF4 (CUGBP Elav-Like Family Member 4)
    8ms
    DNA methylation detection is a significant biomarker for screening endometrial cancer in premenopausal women with abnormal uterine bleeding. (PubMed, Int J Gynecol Cancer)
    In premenopausal women with abnormal uterine bleeding, the clinical efficacy of DNA (CDO1m/CELF4m) methylation detection in exfoliated cervical cells for endometrial cancer screening was better than that of other noninvasive clinical indicators. In addition, dual gene methylation combined with BMI or endometrial thickness was a good predictor of endometrial cancer screening.
    Journal
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    CDO1 (Cysteine Dioxygenase Type 1) • CELF4 (CUGBP Elav-Like Family Member 4)
    8ms
    Pharmacogenomics in pediatric oncology patients with solid tumors related to chemotherapy-induced toxicity: a systematic review. (PubMed, Crit Rev Oncol Hematol)
    For methotrexate, the genes ABCC2, MTHFR, and SXR were associated with myelosuppression and hepatotoxicity...This review highlights the complexity and variability of pharmacogenomic associations with chemotherapy-induced toxicities in pediatric oncology. While certain genetic variants show associations with specific toxicities, larger multinational/center studies are needed to strengthen the associations and improve clinical guidelines.
    Review • Journal
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    ERCC2 (Excision repair cross-complementation group 2) • GSTP1 (Glutathione S-transferase pi 1) • MTHFR (Methylenetetrahydrofolate Reductase) • ABCC2 (ATP Binding Cassette Subfamily C Member 2) • ABCB4 (ATP Binding Cassette Subfamily B Member 4) • ABCC3 (ATP Binding Cassette Subfamily C Member 3) • GSTM1 (Glutathione S-transferase mu 1) • HAS3 (Hyaluronan Synthase 3) • RARG (Retinoic Acid Receptor Gamma) • GSTT1 (Glutathione S-transferase theta 1) • SLC22A2 (Solute Carrier Family 22 Member 2) • SLC28A3 (Solute Carrier Family 28 Member 3) • CELF4 (CUGBP Elav-Like Family Member 4) • COMT (Catechol-O-Methyltransferase)
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    methotrexate
    1year
    Disease characteristics and clinical specific survival prediction of spinal ependymoma: a genetic and population-based study. (PubMed, Front Neurol)
    Previous studies have demonstrated that CELF4 may play a pivotal role in the pathogenesis of SP-EP. Furthermore, this study developed and validated a prognostic prediction model in the form of a nomogram utilizing the SEER database, enabling clinicians to accurately assess treatment risks and benefits, thereby enhancing personalized therapeutic strategies and prognosis predictions.
    Journal
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    CELF4 (CUGBP Elav-Like Family Member 4)
    1year
    Combination of circulating tumor cells, lncRNAs and DNA methylation for the diagnosis of endometrial carcinoma. (PubMed, Oncol Lett)
    The positive rates of the methylated genes CDO1 and CELF4 were 20% (7/35) and 5.71% (2/35), and the P-values of the comparisons between the EC and NO-EC groups were 0.1748 and 0.5004, respectively; the AUC values were 0.6000 and 0.5286. Furthermore, the combination of CTCs, and lncRNAs RP4-616B8.5, RP11-389G6.3 and CTD-2377D24.6 exhibited high performance in the detection of EC (AUC=0.9375).
    Journal • Circulating tumor cells • Epigenetic controller • Tumor cell
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    CDO1 (Cysteine Dioxygenase Type 1) • CELF4 (CUGBP Elav-Like Family Member 4)
    over1year
    CELF4 (rs1786814) gene polymorphism and speckle-tracking Echocardiography for cardiovascular complications in childhood cancer survivors. (PubMed, Pediatr Res)
    Early detection of anthracycline-related cardiotoxicity in childhood cancer survivors (CCS) after finishing chemotherapy. CLEF4 (rs1786814) GG variant is more significant in CCS exposed to high-dose anthracycline. GLPS holds promise as an early predictor of late left ventricular dysfunction and subclinical cardiotoxicity in CCS.
    Journal
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    CELF4 (CUGBP Elav-Like Family Member 4)
    over1year
    DNA methylation detection is a significant biomarker for screening endometrial cancer in premenopausal women with abnormal uterine bleeding. (PubMed, Int J Gynecol Cancer)
    In premenopausal women with abnormal uterine bleeding, the clinical efficacy of DNA (CDO1m/CELF4m) methylation detection in exfoliated cervical cells for endometrial cancer screening was better than that of other noninvasive clinical indicators. In addition, dual gene methylation combined with BMI or endometrial thickness was a good predictor of endometrial cancer screening.
    Journal • Epigenetic controller
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    CDO1 (Cysteine Dioxygenase Type 1) • CELF4 (CUGBP Elav-Like Family Member 4)
    over1year
    The endometrial cancer detection using non-invasive hypermethylation of CDO1 and CELF4 genes in women with postmenopausal bleeding in Northwest China. (PubMed, Cytojournal)
    In addition, 100% of type II EC (n = 6) were positively detected by the CDO1 or CELF4 methylation test. The CDO1 and CELF4 methylation test with high specificity as an auxiliary diagnostic tool or alternative method provides physicians with a reference to distinguish between benign and malignant tumors in women with postmenopausal bleeding, to justify the necessity of using invasive methods to confirm diagnosis.
    Journal
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    CDO1 (Cysteine Dioxygenase Type 1) • CELF4 (CUGBP Elav-Like Family Member 4)
    almost2years
    Genetic architecture of the structural connectome. (PubMed, Nat Commun)
    Heritability is enriched in regions with increased chromatin accessibility in adult oligodendrocytes (as well as microglia, inhibitory neurons and astrocytes) and multiple fetal cell types, suggesting that genetic control of structural connectivity is partially mediated by effects on myelination and early brain development. Our results indicate pervasive, pleiotropic, and spatially structured genetic control of white-matter structural connectivity via diverse neurodevelopmental pathways, and support the relevance of this genetic control to healthy brain function.
    Journal
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    STRN (Striatin) • EPHA3 (EPH receptor A3) • CCDC88C (Coiled-Coil Domain Containing 88C) • MAPT (Microtubule Associated Protein Tau) • MYO16 (Myosin XVI) • NUAK1 (NUAK Family Kinase 1) • SHTN1 (Shootin 1) • DPYSL2 (Dihydropyrimidinase Like 2) • CELF4 (CUGBP Elav-Like Family Member 4) • SEMA3A (Semaphorin 3A)
    almost2years
    Altered CELF4 splicing factor enhances pancreatic neuroendocrine tumors aggressiveness influencing mTOR and everolimus response. (PubMed, Mol Ther Nucleic Acids)
    Interestingly, functional assays and RNA-seq analysis revealed that CELF4 silencing altered mTOR signaling pathway, enhancing the effect of everolimus. We demonstrate that CELF4 is dysregulated in PanNETs, where it influences tumor development and aggressiveness, likely by modulating the mTOR pathway, suggesting its potential as therapeutic target.
    Journal
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    CELF4 (CUGBP Elav-Like Family Member 4)
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    everolimus