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    GENE:

    CEACAM1 (CEA Cell Adhesion Molecule 1)

    i
    Other names: CEACAM1, CEA Cell Adhesion Molecule 1, BGP1, Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (Biliary Glycoprotein), Carcinoembryonic Antigen Related Cell Adhesion Molecule 1, Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1, CD66a Antigen, BGP, Biliary Glycoprotein 1, Antigen CD66, CEACAM1, CD66a, BGP-1, BGPI
    8d
    Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility. (PubMed, Adv Sci (Weinh))
    Pharmacological inhibition of USP7 with FT671 and XL177A reduces KDM6A stability and viral receptor expression, and confers resistance to MERS-CoV, SARS-CoV, and all major SARS-CoV-2 variants of concern, including those resistant to remdesivir in primary human airway and intestinal epithelial cells. In mice, FT671 treatment was well tolerated, reduced Ceacam1 expression, and protected against MHV-A59 infection. Collectively, our findings unveil an antagonistic ubiquitin-mediated regulatory circuit that controls KDM6A stability, viral receptor levels, and coronavirus infection.
    Journal
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    KDM6A (Lysine Demethylase 6A) • CEACAM1 (CEA Cell Adhesion Molecule 1) • USP7 (Ubiquitin Specific Peptidase 7)
    26d
    Protumorigenic Responses of CEACAM6 in Helicobacter pylori-Infected Gastric Cancer Cells. (PubMed, J Cell Mol Med)
    In summary, CEACAM6 was found to promote GC aggressiveness and alter macrophage polarisation. This information could be harnessed to develop future therapeutics for targeting GC.
    Journal
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    CEACAM5 (CEA Cell Adhesion Molecule 5) • CEACAM6 (CEA Cell Adhesion Molecule 6) • CEACAM1 (CEA Cell Adhesion Molecule 1)
    1m
    Yeast-mediated display: probing Helicobacter pylori HopQ and CEACAM1 interaction. (PubMed, Iran J Microbiol)
    Yeast-displayed C1ND specifically bound HopQ-GFP and GFP-expressing H. pylori. Yeast surface display of CEACAM1's N-domain is an effective model for studying HopQ-CEACAM1 binding and offers potential for identifying inhibitors to block H. pylori adhesion and associated disorders.
    Journal
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    CEACAM1 (CEA Cell Adhesion Molecule 1)
    2ms
    Oral Microbiota and Carcinogenesis: Exploring the Systemic Impact of Oral Pathogens. (PubMed, Pathogens)
    Plausible dissemination along an oral-gut-systemic axis, hematogenous, lymphatic, microaspiration, and direct mucosal transfer enables distal effects. While causality is not yet definitive, cumulative data support oral dysbiosis as a clinically relevant cofactor, motivating biomarker-based risk stratification, saliva/stool assays for early detection, and microbiome-targeted interventions (periodontal care, antimicrobials, probiotics, and microbiota modulation) alongside conventional cancer control.
    Review • Journal • IO biomarker
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    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • CEACAM1 (CEA Cell Adhesion Molecule 1)
    2ms
    Spatial transcriptomics defines the molecular progression, invasion and immune landscape of IPMN and IPMN-derived pancreatic cancer. (PubMed, Gut)
    This study provides a spatially resolved molecular map of IPMN progression, delineating key transcriptomic and immune signatures. These findings advance the understanding of IPMN biology and highlight potential biomarkers for risk stratification and therapeutic strategies.
    Journal
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    CLDN1 (Claudin 1) • CEACAM1 (CEA Cell Adhesion Molecule 1) • TFF1 (Trefoil Factor 1) • MUC5AC (Mucin 5AC)
    3ms
    Colorectal cancer organoids drive hypoxia, TGF-β, and patient-specific diversification of NK cell activation programs. (PubMed, J Immunother Cancer)
    The NK cell/PDO co-culture platform allows the identification of both common and patient-specific impacts of the tumor microenvironment on NK cell function and can aid the development of patient-tailored immunotherapies. The majority of CRC (CMS2/CMS3) PDOs from our cohort were susceptible to NK cell-mediated killing and induced NK cell activation, highlighting the potential of NK cells for CRC immunotherapies.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • EPAS1 (Endothelial PAS domain protein 1) • TGFB1 (Transforming Growth Factor Beta 1) • CEACAM1 (CEA Cell Adhesion Molecule 1) • NKG2D (killer cell lectin like receptor K1)
    3ms
    Evaluation of expression profiles of APOA4, CEACAM1, CD147, DJ-1/PARK7, Gamma-synuclein, S100A1, and Stathmin-1 in urothelial carcinomas using immunohistochemical assays. (PubMed, Front Oncol)
    These markers, when integrated with cytology, could enhance the diagnostic precision and reduce dependence on invasive cystoscopy. The proposed cutoffs (10%-20% positive cells or Allred score ≤2) offer clinically actionable threshold for histopathological practice.
    Journal
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    CEACAM1 (CEA Cell Adhesion Molecule 1) • BSG (Basigin (Ok Blood Group)) • STMN1 (Stathmin 1)
    3ms
    CEACAM1 regulates autophagy in oral squamous cell carcinoma through the PPAR signaling pathway. (PubMed, J Stomatol Oral Maxillofac Surg)
    CEACAM1 regulates the PPAR signaling pathway key molecules, affecting OSCC cell autophagy, mitochondrial balance, and apoptosis.
    Journal • IO biomarker
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    NRF1 (Nuclear Respiratory Factor 1) • CEACAM1 (CEA Cell Adhesion Molecule 1) • MFN2 (Mitofusin 2) • TFAM (Transcription Factor A, Mitochondrial)
    3ms
    Immune transcriptomic changes in Australian Gulf War veterans. (PubMed, PLoS One)
    This investigation elucidates the potential role of immune dysregulation underlying GWI, emphasising the importance of immune exhaustion pathways in disease progression. Further investigations in a larger cohort may further elucidate or confirm these identified markers for potential screening or therapeutic applications in GWI.
    Journal • IO biomarker
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    IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • MMP9 (Matrix metallopeptidase 9) • CEACAM1 (CEA Cell Adhesion Molecule 1) • IGHG1 (Immunoglobulin Heavy Constant Gamma 1) • IL7 (Interleukin 7) • SIGLEC1 (Sialic Acid Binding Ig Like Lectin 1)
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    nCounter® Immune Exhaustion Panel
    3ms
    Can Immune Checkpoint Modulation Redefine Ocular Immunotherapy? Emerging Mechanisms, Challenges, and Translational Opportunities-A Comprehensive Review. (PubMed, Invest Ophthalmol Vis Sci)
    It is essential to explore effective combinations of checkpoint inhibitors, determine the optimal timing for their use, and establish better criteria for patient selection. As research on immune checkpoint therapies progresses, they have the potential to transform the management of ocular diseases, offering innovative treatment options for patients who previously had limited choices.
    Review • Journal • PD(L)-1 Biomarker • IO biomarker
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    LAG3 (Lymphocyte Activating 3) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • TNFRSF9 (TNF Receptor Superfamily Member 9) • IL10 (Interleukin 10) • TGFB1 (Transforming Growth Factor Beta 1) • CEACAM1 (CEA Cell Adhesion Molecule 1)
    3ms
    The analytical performance and clinical application of magnetic microparticle chemiluminescent immunoassay for the determination of serum CEACAM1. (PubMed, J Pharm Biomed Anal)
    The area under the ROC curve (AUC) of CEACAM1 in solid tumor patients vs healthy controls was 0.841, which was better than 0.614 of CEA. CLIA is a rapid and reliable detection method for detecting serum CEACAM1 level, which maybe helpful for the diagnosis of some tumors.
    Journal
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    CEACAM1 (CEA Cell Adhesion Molecule 1)
    4ms
    CTTN overexpression in HNSCC inhibits Anoikis-apoptosis. (PubMed, Sci Rep)
    Furthermore, we found that inhibiting the apoptosis-related gene CTTN suppresses the anti-apoptotic capacity of HNSCC. Results from HNSCC-PDOs suggest that CTTN may represent a key target for HNSCC invasion and treatment.
    Journal
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    TTN (Titin) • SPP1 (Secreted Phosphoprotein 1) • PLK1 (Polo Like Kinase 1) • MAPK1 (Mitogen-activated protein kinase 1) • SLCO1B3 (Solute carrier organic anion transporter family member 1B3) • CEACAM1 (CEA Cell Adhesion Molecule 1) • SFRP1 (Secreted frizzled related protein 1) • SPINK1 (Serine peptidase inhibitor, kazal type 1) • CTTN (Cortactin) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MAPK11 (Mitogen-Activated Protein Kinase 11) • PIK3R2 (Phosphoinositide-3-Kinase Regulatory Subunit 2 ) • PLAU (Plasminogen Activator) • PTK2 (Protein Tyrosine Kinase 2) • SPHK1 (Sphingosine Kinase 1)