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BIOMARKER:

CDYL2 overexpression

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Other names: CDYL2, Chromodomain Y Like 2, Chromodomain Y-Like Protein 2, CDY-Like 2, FLJ38866, Prostate Cancer Candidate Protein 1, PCCP1, Chromodomain Protein, Y-Like 2, PCCP1
Entrez ID:
almost2years
circCDYL2 promotes trastuzumab resistance via sustaining HER2 downstream signaling in breast cancer. (PubMed, Mol Cancer)
circCDYL2-GRB7-FAK complex plays a critical role in maintaining HER2 signaling, which contributes to trastuzumab resistance and circCDYL2 is a potential biomarker for trastuzumab-resistance in HER2 BC patients.
Journal
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HER-2 (Human epidermal growth factor receptor 2) • GRB7 (Growth Factor Receptor Bound Protein 7) • CDYL2 (Chromodomain Y Like 2)
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HER-2 positive • CDYL2 overexpression
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Herceptin (trastuzumab)