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    BIOMARKER:

    CDK6 expression

    i
    Other names: CDK6, PLSTIRE, Cyclin-dependent kinase 6
    Entrez ID:
    1021
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    Associations

    News

    Trials
    4ms
    An Essential Role of c-Fos in Notch1-mediated Promotion of Proliferation of KSHV-Infected SH-SY5Y Cells. (PubMed, Curr Mol Pharmacol)
    Our findings strongly indicate that c-Fos plays a crucial role in the promotion of cell proliferation through Notch1 signaling in KSHV-infected cells. Furthermore, our results suggest that the inhibition of expression of key viral pathogenic proteins is likely involved in this process.
    Journal
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    NOTCH1 (Notch 1) • CCND1 (Cyclin D1) • CDK4 (Cyclin-dependent kinase 4) • CDK6 (Cyclin-dependent kinase 6) • FOS (Fos Proto-Oncogene AP-1 Transcription Factor Subunit 2)
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    CCND1 expression • CCND1 expression + CDK4 expression • CDK6 expression
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    LY-411575
    11ms
    Mechanism of resistance to CDK4/6 inhibitors in breast cancer (ChiCTR2400092207)
    P=N/A, N=200, Breast Surgery of the First Hospital of China Medical University; The First Affiliated Hospital of China Medical University
    New trial
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    PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • DKK1 (dickkopf WNT signaling pathway inhibitor 1) • CDK6 (Cyclin-dependent kinase 6) • NCAM1 (Neural cell adhesion molecule 1) • CD68 (CD68 Molecule) • FOXP3 (Forkhead Box P3)
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    PD-L1 expression • PD-1 expression • NCAM1 expression • CDK6 expression • FOXP3 expression
    11ms
    Design and synthesis of new 1,2,3-triazole derivatives as VEGFR-2/telomerase downregulatory candidates endowed with apoptotic potential for cancer treatment. (PubMed, Bioorg Chem)
    Obviously, compound 5a halted the cell cycle at the G1, S, and G2-M phases in HCT116 cells. Subsequently, the synthesized 1,2,3-triazole analogues can be treated as lead VEGFR-2 and telomerase inhibitors with potential apoptotic activity for future optimization and cancer treatment.
    Journal
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    KDR (Kinase insert domain receptor) • CDK4 (Cyclin-dependent kinase 4) • CDK6 (Cyclin-dependent kinase 6) • CASP8 (Caspase 8) • CDK2 (Cyclin-dependent kinase 2) • CASP9 (Caspase 9)
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    KDR expression • CDK6 expression
    1year
    Maslinic acid induces autophagy and ferroptosis via transcriptomic and metabolomic reprogramming in prostate cancer cells. (PubMed, Front Pharmacol)
    In vivo, we demonstrated that 50 mg/kg MA significantly inhibited the growth of tumors established using RM-1 cells. To summarize, we report that MA inhibits prostate cancer cell growth both in vitro and in vivo by inducing autophagy and ferroptosis via transcriptomic and metabolomic reprogramming.
    Journal • Metabolomic study
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    TP53 (Tumor protein P53) • RB1 (RB Transcriptional Corepressor 1) • mTOR (Mechanistic target of rapamycin kinase) • CDK4 (Cyclin-dependent kinase 4) • CDK6 (Cyclin-dependent kinase 6) • GPX4 (Glutathione Peroxidase 4) • CDK2 (Cyclin-dependent kinase 2) • SLC7A11 (Solute Carrier Family 7 Member 11) • ATG5 (Autophagy Related 5) • NFKBIA (NFKB Inhibitor Alpha 2) • ABCA1 (ATP Binding Cassette Subfamily A Member 1) • ATG7 (Autophagy Related 7) • BECN1 (Beclin 1) • JUN (Jun proto-oncogene)
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    TP53 expression • GPX4 expression • CDK6 expression
    1year
    A molecular and immunohistochemical study of 37 cases of ovarian Sertoli-Leydig cell tumor. (PubMed, Virchows Arch)
    DICER1MUT and DICER1WT tumors showed different mRNA expression profiles. The FOXL2 mutation is less common in these tumors and is mutually exclusive with the DICER1 mutation.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • FGFR2 (Fibroblast growth factor receptor 2) • PTEN (Phosphatase and tensin homolog) • AR (Androgen receptor) • TERT (Telomerase Reverse Transcriptase) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • NOTCH2 (Notch 2) • CDK6 (Cyclin-dependent kinase 6) • CA9 (Carbonic anhydrase 9) • MUC4 (Mucin 4, Cell Surface Associated) • DICER1 (Dicer 1 Ribonuclease III) • CD99 (CD99 Molecule) • PRKCA (Protein Kinase C Alpha) • FOXL2 (Forkhead Box L2) • HNF1A (HNF1 Homeobox A)
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    PD-L1 negative • PTEN expression • TERT mutation • TERT promoter mutation • CTLA4 expression • MUC4 expression • CA9 expression • CDK6 expression
    1year
    Nicotinamide mononucleotide protects STAT1 from oxidative stress-induced degradation to prevent colorectal tumorigenesis. (PubMed, MedComm (2020))
    These results indicate that oxidative stress induces STAT1 degradation in tumor cells and possibly in CAC tissues, whereas supplementation with NMN protects STAT1 from oxidation-induced degradation and prevents tumorigenesis. This study provides experimental evidence for the development of NMN-mediated chemoprevention strategies for CRC.
    Journal
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    CDK6 (Cyclin-dependent kinase 6) • STAT1 (Signal Transducer And Activator Of Transcription 1)
    |
    CDK6 expression
    1year
    Lnc NEAT1 facilitates the progression of melanoma by targeting the miR-152-3p/CDK6 axis: An observational study. (PubMed, Medicine (Baltimore))
    Furthermore, the miR-152-3p/ CDK6 axis was implicated in the progression of melanoma accelerated by Lnc NEAT1. Taken together, Lnc NEAT1 may promote melanoma development by serving as an endogenous sponge of miR-152-3p, increasing CDK6 expression, and identifying a new target for the treatment of melanoma.
    Observational data • Journal
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    CDK6 (Cyclin-dependent kinase 6) • NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) • MIR152 (MicroRNA 152)
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    CDK6 expression
    1year
    Anti colorectal cancer activity and in silico studies of novel pyridine nortopsentin analog as cyclin dependent kinase 6 inhibitor. (PubMed, Sci Rep)
    4i also demonstrated a high potential for oral bioavailability due to its adherence to Lipinski's rule of five. The molecular docking studies of 4i analog showed good binding mode with CDK6 active pocket through the formation of multiple interactions with its key amino acids.
    Journal
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    CDK4 (Cyclin-dependent kinase 4) • CDK6 (Cyclin-dependent kinase 6) • CDK2 (Cyclin-dependent kinase 2)
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    CDK2 expression • CDK6 expression
    1year
    Key Genes Involved in the Beneficial Mechanism of Hyperbaric Oxygen for Glioblastoma and Predictive Indicators of Hyperbaric Oxygen Prolonging Survival in Glioblastoma Patients. (PubMed, Curr Med Sci)
    HBO is beneficial for glioblastoma. Glioblastoma patients with these predictive indicators may prolong survival with HBO therapy. These potential therapeutic targets especially COL1A1, ADAMTS1 and PTBP3 deserve further validation.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    NF1 (Neurofibromin 1) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • PD-1 (Programmed cell death 1) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • MDM4 (The mouse double minute 4) • CDK6 (Cyclin-dependent kinase 6) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • CA9 (Carbonic anhydrase 9) • COL1A1 (Collagen Type I Alpha 1 Chain) • MMP9 (Matrix metallopeptidase 9) • PCNA (Proliferating cell nuclear antigen) • ADAMTS1 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 1) • CDC42 (Cell Division Cycle 42) • CDKN1B (Cyclin dependent kinase inhibitor 1B) • CXCR5 (C-X-C Motif Chemokine Receptor 5) • DDIT3 (DNA-damage-inducible transcript 3) • IGFBP3 (Insulin-like growth factor binding protein 3) • IGFBP5 (Insulin Like Growth Factor Binding Protein 5) • BAK1 (BCL2 Antagonist/Killer 1) • CDC25A (Cell Division Cycle 25A) • COL12A1 (Collagen Type XII Alpha 1 Chain) • COL8A1 (Collagen Type VIII Alpha 1 Chain) • EFEMP1 (EGF Containing Fibulin Extracellular Matrix Protein 1) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MCM2 (Minichromosome maintenance complex component 2) • RHOJ (Ras Homolog Family Member J) • NLRP2 (NLR Family Pyrin Domain Containing 2)
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    TP53 expression • CXCL12 expression • CDK6 expression • CDKN1B expression • PCNA expression
    1year
    Enhancing radiosensitivity in osteosarcoma via CDKN2C overexpression: A mechanism involving G1 phase arrest mediated by inhibition of CDK4 expression and Thr172 phosphorylation. (PubMed, Biochem Biophys Res Commun)
    Our research results indicate that overexpression of CDKN2C enhances radiosensitivity in osteosarcoma through the induction of G1 phase arrest and subsequent apoptosis. G1 phase arrest is mediated by the suppression of CDK4 expression and Thr172 phosphorylation, which consequently affects the expression of phosphorylated RB at the Ser807/811 sites.
    Journal
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    CCND1 (Cyclin D1) • CDK4 (Cyclin-dependent kinase 4) • CDK6 (Cyclin-dependent kinase 6) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CDKN2C (Cyclin Dependent Kinase Inhibitor 2C)
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    CCND1 expression • BAX expression • CCND1 expression + CDK4 expression • CDK6 expression
    1year
    Study on the Role of EPHB6 in Inhibiting the Malignant Progression of Cervical Cancer C33A Cells by Binding to CBX7. (PubMed, Cell Biochem Biophys)
    EPHB6 expression is reduced in cervical cancer tissues and cells. Its overexpression inhibits proliferation, invasion, migration, and cell cycle acceleration in C33A cells, exhibiting synergy when bound to CBX7.
    Journal
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    CDK4 (Cyclin-dependent kinase 4) • CDK6 (Cyclin-dependent kinase 6) • MMP2 (Matrix metallopeptidase 2) • MMP9 (Matrix metallopeptidase 9)
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    CDK6 expression
    1year
    Umbelliprenin improved anti-proliferative effects of ionizing radiation on adult T-cell leukemia/lymphoma cells via interaction with CDK6; an in vitro and in silico study. (PubMed, Int J Immunopathol Pharmacol)
    Molecular docking revealed a favorable binding interaction between UMB and the ATP-binding site of CDK6, with a JAMDA score of -2.131, surpassing the control selonsertib. The current study provides evidence that UMB enhances the anti-proliferative effects of IR on ATL cells, and highlights the significance of targeting CDK6 in combinatorial approaches.
    Preclinical • Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CD44 (CD44 Molecule) • CDK6 (Cyclin-dependent kinase 6) • CFLAR (CASP8 and FADD-like apoptosis regulator) • ANXA5 (Annexin A5)
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    MYC overexpression • CDK6 overexpression • CDK6 expression