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    GENE:

    CDK15 (Cyclin Dependent Kinase 15)

    i
    Other names: CDK15, Cyclin Dependent Kinase 15, Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 7 Protein, Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 7, Serine/Threonine-Protein Kinase PFTAIRE-2, Serine/Threonine-Protein Kinase ALS2CR7, Cell Division Protein Kinase 15, Cyclin-Dependent Kinase 15, PFTAIRE Protein Kinase 2, PFTAIRE2, ALS2CR7, PFTK2, Serine/Threonine Protein Kinase
    almost3years
    Rohitukine content across the geographical distribution of Dysoxylum binectariferum Hook F. and its natural derivatives as potential sources of CDK inhibitors. (PubMed, Heliyon)
    The chromone alkaloids, majorly rohitukine and its analogues were closely clustered with flavopiridol, P-276-00 and IIIM-290 along with other chrotacumines in the chemical phylogeny. In conclusion, D. binectariferum is a rich source of chromone alkaloids, which could lead to the discovery of more potential scaffolding for CDK inhibitors as anticancer drugs.
    Journal
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    CDK1 (Cyclin-dependent kinase 1) • CDK15 (Cyclin Dependent Kinase 15)
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    alvocidib (DSP-2033) • riviciclib (P27600)
    over3years
    Identification of exosomal hsa-miR-483-5p as a potential biomarker for hepatocellular carcinoma via microRNA expression profiling of tumor-derived exosomes. (PubMed, Exp Cell Res)
    CDK15 was confirmed to bind with miR-483-5p directly, and thus, miR-483-5p may function by downregulating CDK15. Hsa-miR-483-5p represents a potential specific and sensitive biomarker for HCC diagnosis.
    Journal
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    CDK15 (Cyclin Dependent Kinase 15) • MIR483 (MicroRNA 483)
    over4years
    CDK15 promotes colorectal cancer progression via phosphorylating PAK4 and regulating β-catenin/ MEK-ERK signaling pathway. (PubMed, Cell Death Differ)
    Thus, our data reveal the pivotal role of CDK15 in CRC progression and demonstrate CDK15 promotes CRC tumorigenesis by phosphorylating PAK4. Hence, the CDK15-PAK4 axis may serve as a novel therapeutic target for CRC.
    Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CDK15 (Cyclin Dependent Kinase 15)
    over4years
    Cyclin-dependent kinase 15 upregulation is correlated with poor prognosis for patients with breast cancer. (PubMed, J Int Med Res)
    Upregulated CDK15 predicted poor clinical outcomes in breast cancer.
    Clinical • Observational data • Journal
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    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor) • CDK15 (Cyclin Dependent Kinase 15)