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    GENE:

    CDK14 (Cyclin Dependent Kinase 14)

    i
    Other names: CDK14, Cyclin Dependent Kinase 14, Serine/Threonine-Protein Kinase PFTAIRE-1, Cell Division Protein Kinase 14, Cyclin-Dependent Kinase 14, PFTAIRE Protein Kinase 1, PFTAIRE1, PFTK1, HPFTAIRE1, KIAA0834
    2ms
    IRX3-CDK14 axis promotes glioblastoma progression by regulating LRP6-mediated canonical Wnt/β-catenin pathway. (PubMed, Cell Death Dis)
    In addition, we identify LRP6 (LDL receptor-related protein 6) as a crucial regulatory factor in maintaining IRX3-mediated stabilization of β-catenin. Our results demonstrate that IRX3 serves as a promising biomarker for patients with GBM, and targeting the IRX3-CDK14-LRP6 axis may represent a viable treatment approach for GBM.
    Journal
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    CD14 (CD14 Molecule) • CDK14 (Cyclin Dependent Kinase 14) • FTO (Alpha-Ketoglutarate-Dependent Dioxygenase FTO)
    4ms
    Targeting PABPC1: A Therapeutic Strategy of Natural Ganoderma Meroterpenoid LZ22 against Triple-Negative Breast Cancer Proliferation. (PubMed, Pharmacol Res)
    Furthermore, through structural optimization of LZ22 guided by molecular docking, we identified a derivative (LZ22-4) with enhanced anti-tumor proliferative activity. These findings not only identify PABPC1 as a valuable therapeutic target for TNBC but also provide new opportunities and novel insights for advancing anti-TNBC drug development with LZ22 as a potential drug leading compound.
    Journal
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    NR4A3 (Nuclear receptor subfamily 4 group A member 3) • CD14 (CD14 Molecule) • CDK14 (Cyclin Dependent Kinase 14) • PABPC1 (Poly(A) Binding Protein Cytoplasmic 1)
    5ms
    5-Hydroxytryptamine promotes non-small cell lung cancer metastasis via the SNRPG/WT1/CDK14 Axis. (PubMed, Mol Biomed)
    Loss of SNRPG led to WT1 accumulation, which in turn bound to the CDK14 promoter and activated transcription, ultimately driving NSCLC metastasis. These findings collectively suggest that the 5-HT/SNRPG/WT1/CDK14 axis plays a pivotal role in promoting NSCLC metastasis and highlight 5-HT and SNRPG as potential therapeutic targets for NSCLC metastasis.
    Journal
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    WT1 (WT1 Transcription Factor) • CD14 (CD14 Molecule) • CDK14 (Cyclin Dependent Kinase 14)
    7ms
    RETRACTION: Long Non-Coding RNA SNHG15 Promotes CDK14 Expression via miR-486 to Accelerate Non-Small Cell Lung Cancer Cells Progression and Metastasis. (PubMed, J Cell Physiol)
    Therefore, the editors have lost confidence in the data presented and have decided to retract the article. The authors and their affiliated institution were informed about the concerns and the decision to retract, but they remained unresponsive.
    Journal
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    CD14 (CD14 Molecule) • CDK14 (Cyclin Dependent Kinase 14) • SNHG5 (Small Nucleolar RNA Host Gene 5) • MIR486-1 (MicroRNA 486-1) • SNHG15 (Small Nucleolar RNA Host Gene 15)
    10ms
    Cancer type and gene signatures associated with breakthrough infections following COVID-19 mRNA vaccination. (PubMed, NPJ Vaccines)
    We used epidemiological data from 21195 patients with cancer and 180407 matched controls, including in-depth analyses in 216 cancer patients, to discover clinical and molecular determinants that predispose cancer patients to breakthrough infections. Patients with B cell malignancies, with differential expression of CD24, CDK14 and PLEKHG1, were most susceptible to breakthrough infections, suggesting that these patients may require more booster immunisations to ameliorate cellular responses and immune protection against COVID-19.
    Journal • Gene Signature
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    CD14 (CD14 Molecule) • CD24 (CD24 Molecule) • CDK14 (Cyclin Dependent Kinase 14)
    1year
    CDK14 regulates the development and repair of lung. (PubMed, Cell Death Discov)
    Here, we found that genetic ablation of Cdk14 influenced pulmonary vascular endothelial cells and alveolar epithelial cells during mice embryonic development as well as repair of lung after bleomycin or lipopolysaccharide induced injury...Disruption of Cdk14 interferes with IFN-γ induced lung repair in vivo, suggesting potential crosstalk of CDK14 signaling and IFN-γ pathway. Our work highlights the importance of Cdk14 in lung development and regenerative repair through an uncharacterized CDK14- IFN-γ signaling axis.
    Journal
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    IFNG (Interferon, gamma) • CD14 (CD14 Molecule) • STAT1 (Signal Transducer And Activator Of Transcription 1) • CDK14 (Cyclin Dependent Kinase 14)
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    bleomycin
    1year
    Methylation-modulated PFTK1 regulates gefitinib resistance via Wnt/β-catenin signaling in EGFR mutant non-small-cell lung cancer cells. (PubMed, Commun Biol)
    Moreover, FMF-04-159-2, a specific covalent inhibitor of PFTK1, can reverse the effect of PFTK1 on gefitinib resistance in vitro and in vivo. Consequently, these findings shed new light on the mechanism underlying gefitinib resistance, and suggest PFTK1 as a target for gefitinib treatment in NSCLC.
    Journal
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    EGFR (Epidermal growth factor receptor) • CD14 (CD14 Molecule) • DNMT3B (DNA Methyltransferase 3 Beta) • CDK14 (Cyclin Dependent Kinase 14)
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    EGFR mutation
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    gefitinib
    over1year
    N6-methyladenosine-modified circCDK14 promotes ossification of the ligamentum flavum via epigenetic modulation by targeting AFF4. (PubMed, Cell Mol Life Sci)
    The m6A-modified CircCDK14 binding to miR-93-5p played an important role in the osteogenesis of LF cells by targeting AFF4, providing a promising therapeutic target for OLF.
    Journal
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    AFF4 (AF4/FMR2 Family Member 4) • CDK14 (Cyclin Dependent Kinase 14) • MIR93 (MicroRNA 93) • WTAP (WT1 Associated Protein)
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    CDK14 overexpression
    over1year
    Cross-talk between immune cells and tumor cells in non-Hodgkin lymphomas arising in common variable immunodeficiency. (PubMed, Expert Rev Clin Immunol)
    Upregulation of PD-L1-PD-1 pathway may also promote lymphomagenesis in CVID. These abnormalities need to be explored as prognostic or predictive markers of CVID-associated NHLs by large multi-centric studies.
    Review • Journal • PD(L)-1 Biomarker • IO biomarker • Tumor cell • Immune cell
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    MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • CD8 (cluster of differentiation 8) • IGH (Immunoglobulin Heavy Locus) • NOTCH2 (Notch 2) • PIK3CD (Phosphatidylinositol-4 5-Bisphosphate 3-Kinase Catalytic Subunit Delta) • CD4 (CD4 Molecule) • CDK14 (Cyclin Dependent Kinase 14)
    over1year
    Comprehensive transcriptomic analysis of prostate cancer lung metastases. (PubMed, PLoS One)
    In PCa lung metastases genes associated with immunogenic responses are upregulated while genes associated with epithelial-mesenchymal transition are down-regulated. This points to a more immunogenic phenotype of PCa lung metastases thus potentially making patients more susceptible to immunotherapeutic approaches.
    Journal • IO biomarker
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    CXCL10 (Chemokine (C-X-C motif) ligand 10) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • CD14 (CD14 Molecule) • HLA-DPB1 (Major Histocompatibility Complex, Class II, DP Beta 1) • ITGAM (Integrin, alpha M) • SLC44A4 (Solute Carrier Family 44 Member 4) • TWIST1 (Twist Family BHLH Transcription Factor 1) • CCL21 (C-C Motif Chemokine Ligand 21) • CDK14 (Cyclin Dependent Kinase 14) • CXCR3 (C-X-C Motif Chemokine Receptor 3) • SLC4A4 (Solute carrier family 4 member 4) • TBX1 (T-Box Transcription Factor 1) • SERPINA1 (Serpin Family A Member 1) • FOXC2 (Forkhead Box C2)
    almost2years
    Building Resilience at Schools: Emotional and Biological Assessment and Treatment of Traumatic Stress (clinicaltrials.gov)
    P=N/A, N=80800, Recruiting, Stanford University | Not yet recruiting --> Recruiting
    Enrollment open
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    NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • ERBB4 (erb-b2 receptor tyrosine kinase 4) • CD14 (CD14 Molecule) • IGFBP2 (Insulin-like growth factor binding protein 2) • CDK14 (Cyclin Dependent Kinase 14) • HNRNPH1 (Heterogeneous Nuclear Ribonucleoprotein H1) • WTAP (WT1 Associated Protein) • SLC1A3 (Solute Carrier Family 1 Member 3)
    2years
    Building Resilience at Schools: Emotional and Biological Assessment and Treatment of Traumatic Stress (clinicaltrials.gov)
    P=N/A, N=80800, Not yet recruiting, Stanford University
    Trial completion date • Trial primary completion date
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    NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • ERBB4 (erb-b2 receptor tyrosine kinase 4) • CD14 (CD14 Molecule) • IGFBP2 (Insulin-like growth factor binding protein 2) • CDK14 (Cyclin Dependent Kinase 14) • HNRNPH1 (Heterogeneous Nuclear Ribonucleoprotein H1) • WTAP (WT1 Associated Protein) • SLC1A3 (Solute Carrier Family 1 Member 3)