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    DRUG CLASS:

    CDH17-targeted antibody-drug conjugate

    Associations

    News

    Trials
    9d
    A Phase Ib/II Study of HDM2017 in Combination With Standard of Care in Advanced Colorectal Cancer (clinicaltrials.gov)
    P1/2, N=120, Not yet recruiting, Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
    New P1/2 trial
    |
    Fruzaqla (fruquintinib)
    10d
    Evaluation of ICP-B208 in Patients With Advanced Solid Tumors (clinicaltrials.gov)
    P1/2, N=539, Not yet recruiting, Beijing InnoCare Pharma Tech Co., Ltd.
    New P1/2 trial
    20d
    A Study of DB-1324 in Advanced/Metastatic Gastrointestinal Tumors (clinicaltrials.gov)
    P1/2, N=127, Recruiting, DualityBio Inc. | Not yet recruiting --> Recruiting
    Enrollment open • First-in-human
    |
    CDH17 (Cadherin 17)
    24d
    AMT-676 in Patients With Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=24, Recruiting, Multitude Therapeutics Inc. | Trial primary completion date: Oct 2025 --> May 2027 | Trial completion date: Feb 2026 --> Dec 2027
    Trial completion date • Trial primary completion date • First-in-human
    1m
    A Phase Ib/II Trial of HS-20110 Combination Therapies in Advanced Colorectal Cancer Patients. (clinicaltrials.gov)
    P1/2, N=502, Recruiting, Hansoh BioMedical R&D Company | Not yet recruiting --> Recruiting
    Enrollment open
    |
    BRAF (B-raf proto-oncogene) • MSI (Microsatellite instability)
    |
    BRAF V600E • BRAF V600
    |
    Avastin (bevacizumab) • 5-fluorouracil • capecitabine • oxaliplatin • leucovorin calcium
    2ms
    ChefHat-001: Phase 1/2 Study of BHB810 in Advanced Gastric and GEJ Adenocarcinoma (clinicaltrials.gov)
    P1/2, N=164, Not yet recruiting, BigHat Biosciences, Inc.
    New P1/2 trial
    |
    CDH17 (Cadherin 17)
    3ms
    A Phase II Study of AMT-676 Combination Therapies in Advanced Colorectal Cancer (clinicaltrials.gov)
    P2, N=180, Not yet recruiting, Multitude Therapeutics Inc.
    New P2 trial
    |
    Avastin (bevacizumab) • Erbitux (cetuximab) • 5-fluorouracil • oxaliplatin • irinotecan • leucovorin calcium
    5ms
    A Study of LM-350 in Subjects With Advanced Solid Tumours (clinicaltrials.gov)
    P1/2, N=80, Recruiting, LaNova Medicines Limited | Not yet recruiting --> Recruiting | N=55 --> 80
    Enrollment open • Enrollment change • First-in-human
    5ms
    First-in-human Study of 7MW4911 in GI Cancer (clinicaltrials.gov)
    P1/2, N=200, Recruiting, Mabwell (Shanghai) Bioscience Co., Ltd. | Not yet recruiting --> Recruiting
    Enrollment open • First-in-human
    6ms
    A Phase Ib/II Trial of HS-20110 Combination Therapies in Advanced Colorectal Cancer Patients. (clinicaltrials.gov)
    P1/2, N=502, Not yet recruiting, Hansoh BioMedical R&D Company
    New P1/2 trial
    |
    Avastin (bevacizumab) • 5-fluorouracil • capecitabine • oxaliplatin • leucovorin calcium
    6ms
    A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=405, Recruiting, Lepu Biopharma Co., Ltd. | Phase classification: P1/2 --> P1
    Phase classification
    6ms
    A Phase 1 Study of HDM2017 in Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=96, Recruiting, Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
    New P1 trial