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    GENE:

    CDCA3 (Cell Division Cycle Associated 3)

    i
    Other names: Cell Division Cycle Associated 3, TOME-1, GRCC8, Cell Division Cycle-Associated Protein 3, Trigger Of Mitotic Entry Protein 1, Gene-Rich Cluster Protein C8, Trigger Of Mitotic Entry 1, CDCA3, TOME1, C8
    2ms
    Deoxylapachol inhibits esophageal squamous cell carcinoma progression via targeting FOXM1-mediated Wnt/β-catenin pathway. (PubMed, Phytomedicine)
    Our study is the first to demonstrate the potent anti-ESCC effects of DEO. The results indicate DEO may inhibit ESCC progression through targeting FOXM1-mediated Wnt/β-catenin pathway, positioning DEO as a promising candidate for the development of novel ESCC therapeutics.
    Journal
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    CDCA3 (Cell Division Cycle Associated 3) • FOXM1 (Forkhead Box M1) • MYBL2 (MYB Proto-Oncogene Like 2)
    2ms
    TWIST1 Activates CDCA3 to Promote EMT of Lung Adenocarcinoma and Expression of PD-L1. (PubMed, Adv Biol (Weinh))
    Knockdown of TWIST1 attenuated the malignant phenotype and reduced PD-L1 expression in LUAD cells, whereas subsequent overexpression of CDCA3 fully reversed these suppressive effects. This study aims to validate that the TWIST1/CDCA3 axis promotes invasion, migration, proliferation, and PD-L1 expression of LUAD cells.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • CDCA3 (Cell Division Cycle Associated 3) • TWIST1 (Twist Family BHLH Transcription Factor 1)
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    PD-L1 expression
    2ms
    Integrative Bioinformatics and Experimental Validation Establish CCNB1 as a Potential Biomarker for Diagnosis and Prognosis in Colorectal Cancer. (PubMed, Curr Issues Mol Biol)
    In vitro, CCNB1 knockdown triggered cell cycle arrest, thereby suppressing the proliferation of colorectal cancer cells. This study validated CCNB1 as a dual-purpose biomarker for CRC diagnosis and favorable prognosis, highlighting its potential utility in clinical management.
    Journal
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    TOP2A (DNA topoisomerase 2-alpha) • CDCA3 (Cell Division Cycle Associated 3) • CCNA2 (Cyclin A2) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) • CDC20 (Cell Division Cycle 20) • KIF11 (Kinesin Family Member 11) • MCM4 (Minichromosome Maintenance Complex Component 4) • CCNB1 (Cyclin B1) • CDK3 (Cyclin Dependent Kinase 3) • CEP55 (Centrosomal Protein 55) • CKS2 (CDC28 Protein Kinase Regulatory Subunit 2) • CRYAB (Crystallin Alpha B) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MMP3 (Matrix metallopeptidase 3) • TPM2 (Tropomyosin 2) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)
    3ms
    Prognostic role of CDCA3 in lung adenocarcinoma with immune infiltration. (PubMed, Sci Rep)
    While flow cytometry indicated increased apoptosis in CDCA3-knockdown cells, suggesting CDCA3's role in promoting LUAD cell proliferation and survival. These findings indicated that CDCA3 could serve as a valuable prognostic biomarker in LUAD, influencing prognosis, immune response, and drug sensitivity, potentially guiding therapeutic and immunotherapy decisions.
    Journal • IO biomarker
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    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • CDCA3 (Cell Division Cycle Associated 3)
    3ms
    CDCA3 Regulates Tumor-Associated Macrophages Polarize to Promote the Malignant Progression of Hepatocellular Carcinoma. (PubMed, J Hepatocell Carcinoma)
    Our findings suggest that CDCA3 promotes the malignant progression of HCC by driving M2-like TAM polarization, potentially through the upregulation of cytokines such as TGF-β1, VEGFA, CD40, CXCL1, and CXCL5. CDCA3 thus represents a promising diagnostic biomarker and therapeutic target for HCC.
    Journal • IO biomarker
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    CDCA3 (Cell Division Cycle Associated 3) • TGFB1 (Transforming Growth Factor Beta 1) • CD40 (CD40 Molecule) • CXCL5 (Chemokine (C-X-C motif) ligand 5) • CXCL1 (Chemokine (C-X-C motif) ligand 1)
    4ms
    Exploration of oxidative stress-related molecular signature for clear cell renal cell carcinoma. (PubMed, Discov Oncol)
    In conclusion, we conducted a thorough analysis of the expression profiles of OSRGs in ccRCC, culminating in the development of a robust prognostic model and scoring system aimed at accurately predicting survival outcomes for ccRCC patients. This endeavor has the potential to yield novel insights into redox biology and to advance the current treatment strategies for ccRCC.
    Journal • Tumor mutational burden • PD(L)-1 Biomarker • IO biomarker
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    TMB (Tumor Mutational Burden) • CD276 (CD276 Molecule) • VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1) • MAGEA4 (Melanoma antigen family A, 4) • SAA1 (Serum Amyloid A1) • CDCA3 (Cell Division Cycle Associated 3) • IRF6 (Interferon Regulatory Factor 6)
    5ms
    PRC1, CDCA3, and CDC20 are upregulated and Treg numbers are decreased in canine massive hepatocellular carcinoma. (PubMed, BMC Vet Res)
    PRC1, CDCA3, and CDC20 were upregulated and were identified as candidate oncogenic genes in canine massive HCC. Downregulation of Tregs may be associated with prognosis in canine massive HCC.
    Journal
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    CDCA3 (Cell Division Cycle Associated 3) • CDC20 (Cell Division Cycle 20)
    6ms
    Comparative bioinformatics analysis of the Wnt pathway in breast cancer: Selection of novel biomarker panels associated with ER status. (PubMed, Open Life Sci)
    Thus, this study revealed potential diagnostic and prognostic signatures based on comprehensive analyses of BC patient data sourced from The Cancer Genome Atlas database. Consequently, four gene signatures were constructed: two differentiate ER+ from ER-BC: TTC8, SLC5A7, and PLCH1 for overall survival (OS); ZNF695, SLC7A5, and PLCH1 for disease free survival (DFS), while the other two effectively distinguish tumor from normal samples: SPC25, ANLN, KPNA2, SLC7A5 for OS; SPC25, KIF20A, SKA3, DTL, CDCA3, ANLN, TTK, RAD54L, MYBL2, ZNF695, and SLC7A5 for DFS.
    Journal
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    CDCA3 (Cell Division Cycle Associated 3) • RAD54L (DNA Repair And Recombination Protein RAD54) • SLC7A5 (Solute Carrier Family 7 Member 5) • MYBL2 (MYB Proto-Oncogene Like 2) • ANLN (Anillin Actin Binding Protein) • KIF20A (Kinesin Family Member 20A) • KPNA2 (Karyopherin Subunit Alpha 2)
    6ms
    Identification and tissue-level validation of ferroptosis-related genes in small intestinal neuroendocrine neoplasms based on machine learning. (PubMed, BMC Gastroenterol)
    Four core ferroptosis-related genes (CDCA3, CDC25A, CYP4F8, and MYB) were identified in SI-NENs patients, which may aid in developing the diagnostic biomarkers and therapeutic targets in the clinic.
    Journal
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    CDCA3 (Cell Division Cycle Associated 3) • CDC25A (Cell Division Cycle 25A) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)
    6ms
    Pseudouridylation-Related Genes Predict Prognosis and Therapeutic Response in Hepatocellular Carcinoma Patients. (PubMed, J Cancer)
    qPCR experiment confirmed the significant overexpression of RDM1, CDCA3, and FLVCR1 in HCC tissues, being consistent with public database analysis. In conclusion, pseudouridylation related-molecular subtype and risk model may effectively predict the prognosis and therapeutic response of HCC.
    Journal • IO biomarker
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    AFP (Alpha-fetoprotein) • PLK1 (Polo Like Kinase 1) • CDCA3 (Cell Division Cycle Associated 3) • FOXM1 (Forkhead Box M1)
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    TP53 mutation
    7ms
    Ferroptosis-Linked Six-Gene Panel Enables Machine Learning-Assisted Diagnosis and Therapeutic Guidance in Lung Adenocarcinoma. (PubMed, Biology (Basel))
    Functional analyses linked the signature to cell-cycle, angiogenic, and immune modulation, while exploratory drug-gene correlations identified PLK1 and other candidates as potential therapeutic targets. Together, these findings establish a biologically anchored six-gene panel that complements existing mutation-based classifiers and provides a framework for advancing diagnostic precision, prognostic refinement, and biomarker-guided therapeutic strategies in LUAD.
    Journal
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    PLK1 (Polo Like Kinase 1) • CDCA3 (Cell Division Cycle Associated 3) • UHRF1 (Ubiquitin Like With PHD And Ring Finger Domains 1) • KIF20A (Kinesin Family Member 20A)
    7ms
    snoRNP RRP9 Promotes Prostate Cancer Cell Proliferation and Migration via SQSTM1. (PubMed, Adv Biol (Weinh))
    RRP9 is a snoRNP that binds to SQSTM1, thereby promoting PCa cell proliferation and migration. Targeting the RRP9-SQSTM1 axis may be a viable therapeutic strategy for PCa.
    Journal
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    SQSTM1 (Sequestosome 1) • CDCA3 (Cell Division Cycle Associated 3)