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    BIOMARKER:

    CDC42 elevation

    i
    Other names: CDC42, Cell Division Cycle 42, CDC42Hs, G25K, Cell Division Control Protein 42 Homolog, GTP Binding Protein, 25kDa, G25K GTP-Binding Protein, DJ224A6.1.1 (Cell Division Cycle 42 (GTP-Binding Protein, 25kD)), DJ224A6.1.2 (Cell Division Cycle 42 (GTP-Binding Protein, 25kD)), Cell Division Cycle 42 (GTP Binding Protein, 25kDa), Cell Division Cycle 42 (GTP-Binding Protein, 25kD), Small GTP Binding Protein CDC42, Growth-Regulating Protein, TKS
    Entrez ID:
    998
    over2years
    CIP2A interacts with AKT1 to promote the malignant biological behaviors of oral squamous cell carcinoma by upregulating the GSK‑3β/β‑catenin pathway. (PubMed, Exp Ther Med)
    In conclusion, CIP2A could interact with AKT1 to promote the malignant biological behaviors of OSCC cells by upregulating the GSK-3β/β-catenin pathway. These findings may provide a targeted therapy for OSCC treatment.
    Journal
    |
    AKT1 (V-akt murine thymoma viral oncogene homolog 1) • CIP2A (Cellular Inhibitor Of PP2A)
    |
    AKT1 overexpression • CIP2A elevation • CDC42 elevation
    almost3years
    "From molecular to clinic": The pivotal role of CDC42 in pathophysiology of human papilloma virus related cancers and a correlated sensitivity of afatinib. (PubMed, Front Immunol)
    We identified CDC42 as a pivotal gene in the pathophysiology of HPV-related cancers. The upregulation of CDC42 could be a signal for afatinib treatment and the mechanism in which may be an increased affinity of EGFR to afatinib, inferred from a high stability in the quaternary complex of CDC42-GTPase-effector interface-EGFR-afatinib.
    Journal
    |
    EGFR (Epidermal growth factor receptor) • RB1 (RB Transcriptional Corepressor 1) • TAF15 (TATA-Box Binding Protein Associated Factor 15) • CDC42 (Cell Division Cycle 42) • NUP62 (Nucleoporin 62) • PSMD1 (Proteasome 26S Subunit Non-ATPase 1) • KPNA2 (Karyopherin Subunit Alpha 2)
    |
    CDC42 elevation
    |
    Gilotrif (afatinib)