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    GENE:

    CDC25C (Cell Division Cycle 25C)

    i
    Other names: CDC25C, Cell Division Cycle 25C, PPP1R60, Protein Phosphatase 1, Regulatory Subunit 60, M-Phase Inducer Phosphatase 3, CDC25, Dual Specificity Phosphatase CDC25C, Dual Specificity Phosphatase Cdc25C, Phosphotyrosine Phosphatase, CDC25 Homolog C (S. Pombe), Mitosis Inducer CDC25, CDC25 Homolog C
    26d
    Prognostic value and experimental validation of atherosclerosis-derived pathogenic genes in colorectal cancer. (PubMed, Front Oncol)
    A CRC risk model based on 6 AS-related genes was developed, identifying 3 novel AS genes. It highlights shared genetic factors, offering prognostic biomarkers for both diseases and insights into their interconnected mechanisms.
    Journal
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    PALB2 (Partner and localizer of BRCA2) • CDC25C (Cell Division Cycle 25C) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • HMMR (Hyaluronan Mediated Motility Receptor) • KPNA2 (Karyopherin Subunit Alpha 2) • PRR11 (Proline Rich 11)
    1m
    Etiology of polyploid giant cancer cells: a new frontier in cancer biology. (PubMed, Cancer Cell Int)
    Given their unique properties and clinical relevance, PGCCs represent a promising frontier in cancer biology with the potential to overcome therapeutic resistance and prevent tumor recurrence through targeted interventions. This review seeks to elucidate the role of PGCCs across multiple cancer types and highlights their emerging potential as novel targets for future cancer therapies.
    Review • Journal
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    AURKB (Aurora Kinase B) • IL6R (Interleukin 6 receptor) • PLK4 (Polo Like Kinase 4) • CDC25C (Cell Division Cycle 25C) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)
    2ms
    Exosome and BCR-ABL mediated molecular alterations in endothelial cells in chronic myeloid leukemia: identification of seven genes and their regulatory network. (PubMed, PeerJ)
    A competing endogenous RNA (ceRNA) network involving miRNAs (e.g., miR-16-5p, miR-126-5p) and lncRNAs (e.g., AC008124.1, AC064799.2, AGAP11) potentially modulates their expression. This study identifies seven novel candidate biomarkers dysregulated in endothelial cells under combined BCR-ABL and exosomal stimulation, shedding light on the molecular crosstalk between leukemic cells and the vascular niche.
    Journal
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    ABL1 (ABL proto-oncogene 1) • BCR (BCR Activator Of RhoGEF And GTPase) • CDC20 (Cell Division Cycle 20) • CDC25C (Cell Division Cycle 25C) • CREB1 (CAMP Responsive Element Binding Protein 1) • GRM1 (Glutamate Metabotropic Receptor 1) • MIR126 (MicroRNA 126) • MIR16 (MicroRNA 16) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)
    2ms
    Macrophage membrane coating enhances the therapeutic effects of Houttuynia cordata exosome-like nanovesicles against triple-negative breast cancer. (PubMed, Mater Today Bio)
    Collectively, the present study establishes the potential of Houttuynia cordata-derived exosome-like nanovesicles as a natural therapeutic platform against TNBC, with macrophage membrane coating further augmenting their efficacy through biomimetic targeting. MCELNs may represent a promising drug delivery strategy for enhancing treatment efficacy while minimizing systemic toxicity in breast cancer therapy.
    Journal • PARP Biomarker
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    CDK4 (Cyclin-dependent kinase 4) • CHEK1 (Checkpoint kinase 1) • CASP3 (Caspase 3) • CDC25C (Cell Division Cycle 25C) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • H2AX (H2A.X Variant Histone)
    3ms
    Construction and validation of an oxidative phosphorylation-related gene signature in lung squamous cell carcinoma patients. (PubMed, Lung Cancer Manag)
    This signature highlights the clinical relevance of OXPHOS in LUSC prognosis and may guide personalized therapeutic strategies targeting metabolic vulnerabilities. Study limitations include its retrospective design and lack of experimental validation.
    Journal • Gene Signature
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    SAA1 (Serum Amyloid A1) • LTBP1 (Latent-transforming growth factor beta-binding protein 1) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) • CDC25C (Cell Division Cycle 25C) • SAAL1 (Serum Amyloid A Like 1) • CD59 (CD59 Molecule) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)
    5ms
    Delta- and Gamma-Tocotrienols Inhibit the Proliferation of HCC2998 Human Colorectal Carcinoma Cells via Modulation of Histone Modification Pathways Involved in DNA Damage Response. (PubMed, Cell Biol Int)
    These findings indicate that γT3 and δT3 inhibit HCC2998 cell proliferation by activating the DDR pathway, highlighting their potential as therapeutic agents to overcome cell cycle arrest resistance in CRC. This study provides critical insights into the molecular actions of γT3 and δT3, supporting their further investigation as promising candidates for CRC intervention.
    Journal • BRCA Biomarker
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    BRCA1 (Breast cancer 1, early onset) • ATM (ATM serine/threonine kinase) • RAD51 (RAD51 Homolog A) • CDK2 (Cyclin-dependent kinase 2) • PMAIP1 (Phorbol-12-Myristate-13-Acetate-Induced Protein 1) • CCNE2 (Cyclin E2) • CDC25C (Cell Division Cycle 25C) • CDC25A (Cell Division Cycle 25A) • E2F1 (E2F transcription factor 1) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • SMC1A (Structural Maintenance Of Chromosomes 1A)
    5ms
    Quinoline-5,8-dione CDC25 inhibitors: Potent anti-cancer agents in leukemia and patient-derived colorectal organoids. (PubMed, Eur J Med Chem)
    Notably, efficacy was validated in colorectal cancer patient-derived organoids, providing clinically relevant insights into patient-specific responses. Together, these findings define a new class of CDC25 inhibitors with potent and selective anticancer activity, advancing prospects for next-generation therapeutics in leukemia and colorectal cancer.
    Journal
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    CDC25C (Cell Division Cycle 25C) • CDK1 (Cyclin-dependent kinase 1) • RASGRF1 (Ras Protein Specific Guanine Nucleotide Releasing Factor 1) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)
    5ms
    α-hederin inhibits cervical cancer progression by inducing DNA damage-dependent cell cycle blockade and apoptosis. (PubMed, BMC Cancer)
    α-hederin may be an effective drug to inhibit cervical cancer and has a good development prospect.
    Journal
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    CHEK1 (Checkpoint kinase 1) • CDC25C (Cell Division Cycle 25C) • CDK1 (Cyclin-dependent kinase 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • CDC25B (Cell Division Cycle 25B) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)
    5ms
    Cell division cycle 25 C (CDC25C) mediates cell-cycle progression and immune evasion in glioma. (PubMed, Discov Oncol)
    CDC25C is a critical driver of glioma cell proliferation and an enabler of immune evasion. Its overexpression may link unchecked mitotic progression with an immunosuppressive microenvironment, underscoring CDC25C as a promising prognostic biomarker and therapeutic target in glioma.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • PD-1 (Programmed cell death 1) • CDC25C (Cell Division Cycle 25C) • CDK1 (Cyclin-dependent kinase 1) • CCNB1 (Cyclin B1) • CD80 (CD80 Molecule) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)
    5ms
    Air pollution-related immune gene prognostic signature for hepatocellular carcinoma: network toxicology, machine learning and multi-omics analysis. (PubMed, Front Immunol)
    We identified key APIGs and constructed a robust APIG-based prognostic signature for HCC. CDC25C was a key target through which APs impact HCC and multiple other cancers.
    Journal
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    MELK (Maternal Embryonic Leucine Zipper Kinase) • CDC25C (Cell Division Cycle 25C) • APEX1 (Apurinic/Apyrimidinic Endodeoxyribonuclease 1) • ATG4B (Autophagy Related 4B Cysteine Peptidase) • CDC25B (Cell Division Cycle 25B) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • SLC2A1 (Solute Carrier Family 2 Member 1)
    5ms
    Inhibiting Cyclin-Dependent Kinase 13-Mediated Nuclear Ubiquitous Casein Kinase and Cyclin-Dependent Kinase Substrate 1 Phosphorylation Facilitates Oxidative Stress-Induced Apoptosis in Melanoma. (PubMed, Mol Carcinog)
    Furthermore, we found that p-NUCKS1 was highly expressed in tumor specimens from melanoma patients, and silencing of NUCKS1 inhibited tumor growth in melanoma A375 and A875-bearing mouse models. Therefore, p-NUCKS1 could act as a potential target for melanoma treatment by mediating oxidative stress-induced apoptosis.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • CHEK2 (Checkpoint kinase 2) • CDC25C (Cell Division Cycle 25C) • CDK13 (Cyclin Dependent Kinase 13) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta)