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    BIOMARKER:

    CDC25C overexpression

    i
    Other names: CDC25C, Cell Division Cycle 25C, PPP1R60, Protein Phosphatase 1, Regulatory Subunit 60, M-Phase Inducer Phosphatase 3, CDC25, Dual Specificity Phosphatase CDC25C, Dual Specificity Phosphatase Cdc25C, Phosphotyrosine Phosphatase, CDC25 Homolog C (S. Pombe), Mitosis Inducer CDC25, CDC25 Homolog C
    Entrez ID:
    995
    over3years
    The Risk Model Based on the Three Oxidative Stress-Related Genes Evaluates the Prognosis of LAC Patients. (PubMed, Oxid Med Cell Longev)
    In summary, ERO1A, CDC25C, and ITGB4 of OSRGs are associated with poor prognosis of LAC patients. We confirmed that the risk model based on the ERO1A, CDC25C, and ITGB4 is expected to assess the prognosis of LAC patients.
    Journal
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    CD8 (cluster of differentiation 8) • PLK1 (Polo Like Kinase 1) • CCNA2 (Cyclin A2) • CDC25C (Cell Division Cycle 25C) • CDK1 (Cyclin-dependent kinase 1) • ERO1A (Endoplasmic Reticulum Oxidoreductase 1 Alpha) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)
    |
    CDC25C overexpression
    over3years
    RACGAP1 promotes proliferation and cell cycle progression by regulating CDC25C in cervical cancer cells. (PubMed, Tissue Cell)
    In mechanism, overexpression of CDC25C attenuated RACGAP1 knockdown-mediated cell growth inhibition and cell cycle arrest. Taken together, this study demonstrated that RACGAP1 was overexpressed in cervical cancer, and downregulation of RACGAP1 could inhibit the cervical cancer cell proliferation and cell cycle progression through regulating CDC25C expression.
    Journal
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    CDC25C (Cell Division Cycle 25C) • CDK1 (Cyclin-dependent kinase 1) • CCNB1 (Cyclin B1) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • RACGAP1 (Rac GTPase activating protein 1)
    |
    CDC25C overexpression
    over3years
    CDC25C is a prognostic biomarker and correlated with mitochondrial homeostasis in pancreatic adenocarcinoma. (PubMed, Bioengineered)
    To summarize, CDC25C may be involved in energy metabolism by maintaining mitochondrial homeostasis. Our results suggested that CDC25C is a potential biological marker and promising therapeutic target of PAAD.
    Journal
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    CDC25C (Cell Division Cycle 25C) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)
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    CDC25C overexpression