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    GENE:

    CDC25A (Cell Division Cycle 25A)

    i
    Other names: Cell Division Cycle 25A, M-Phase Inducer Phosphatase 1, Dual Specificity Phosphatase CDC25A, Dual Specificity Phosphatase Cdc25A, CDC25 Homolog A (S. Pombe), CDC25 Homolog A, CDC25A2, CDC25A
    Associations

    News

    Trials
    18d
    Quorum-Sensing Regulator C8-HSL Promotes the Proliferation, Migration, and Invasion of Lung Cancer Cells by Activating the PI3K/AKT/ERK Pathway. (PubMed, FASEB J)
    This is the first report of C8-HSL as a promoter of lung cancer cell proliferation, migration, and invasion. Taken together, C8-HSL is a potential risk factor for lung cancer, and strategies targeting C8-HSL-producing bacteria and monitoring C8-HSL concentrations may be beneficial for the prevention and control of lung cancer.
    Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CCNE1 (Cyclin E1) • CDH1 (Cadherin 1) • MMP9 (Matrix metallopeptidase 9) • CDC25A (Cell Division Cycle 25A) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)
    1m
    Regulation of INSM1 Gene Expression and Neuroendocrine Differentiation in High-Risk Neuroblastoma. (PubMed, Biology (Basel))
    INSM1 overexpression in SH-SY-5Y cells upregulated neuroendocrine and thyroid hormone-related genes (CHGA, CHGB, DDC, NCAM1, DIO3, TH), while suppressing genes involved in cell cycle (RRM, CDC25A), methionine metabolism (AHCY, MAT2A), transcriptional regulation (MYBL2, EZH2), and oncogenic signaling (ALK, LINC011667). These findings suggest that INSM1 promotes NB aggressiveness by sustaining a neuroendocrine progenitor-like phenotype through metabolic-epigenetic coupling.
    Journal
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    ALK (Anaplastic lymphoma kinase) • MYCN (MYCN Proto-Oncogene BHLH Transcription Factor) • NCAM1 (Neural cell adhesion molecule 1) • MYBL2 (MYB Proto-Oncogene Like 2) • CDC25A (Cell Division Cycle 25A) • CHGA (Chromogranin A) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • INSM1 (INSM Transcriptional Repressor 1) • MAT2A (Methionine Adenosyltransferase 2A)
    2ms
    First-in-Class Quinoline-Dione-Derived PROTACs: Potent Degraders of Cdc25 Phosphatases for Antitumor Therapy. (PubMed, J Med Chem)
    Mechanistically, D3 exerts antitumor effects by degrading the target protein Cdc25, upregulating p-CDK1/2 levels, and subsequently inducing G2/M phase cell cycle arrest and apoptosis. This study validates PROTACs as a breakthrough strategy to target "undruggable" Cdc25, provides a novel quinoline-dione-based scaffold for antitumor drug development, and offers a rational design paradigm for tackling intractable phosphatase targets.
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    CDK1 (Cyclin-dependent kinase 1) • RASGRF1 (Ras Protein Specific Guanine Nucleotide Releasing Factor 1) • CDC25A (Cell Division Cycle 25A) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)
    2ms
    USP1 regulates esophageal cancer progression through CDC25A deubiquitination to regulate CDK1 expression. (PubMed, 3 Biotech)
    In conclusion, our findings suggest that the USP1/CDC25A/CDK1 axis influences esophageal carcinogenesis and progression. The online version contains supplementary material available at 10.1007/s13205-025-04663-1.
    Journal
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    CDK1 (Cyclin-dependent kinase 1) • CDC25A (Cell Division Cycle 25A) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • USP1 (Ubiquitin Specific Peptidase 1)
    2ms
    Paeoniflorin promotes therapeutic senescence in melanoma through endoplasmic reticulum stress and the calpain1/ERK5/p27 axis. (PubMed, Phytomedicine)
    Paeoniflorin induces melanoma cell senescence through the ER stress/calpain1/ERK5/p27 signaling axis, suggesting its potential as a novel therapeutic strategy against SKCM.
    Journal
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    CDKN1B (Cyclin dependent kinase inhibitor 1B) • CAPN1 (Calpain 1) • CDC25A (Cell Division Cycle 25A) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • LAMA1 (Laminin Subunit Alpha 1)
    2ms
    Identification of a Novel miR-122-5p/CDC25A Axis and Potential Therapeutic Targets for Chronic Myeloid Leukemia. (PubMed, Int J Mol Sci)
    Modulating the miR-122-5p/CDC25A axis may provide potential molecular targets for inhibiting CML progression through regulation of cell cycle pathways. Findings are exploratory and based on bioinformatics with limited in vitro expression confirmation; functional studies are required to establish causality.
    Journal
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    CDK4 (Cyclin-dependent kinase 4) • CDC25A (Cell Division Cycle 25A) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • MIR122 (MicroRNA 122)
    3ms
    microRNA-100 inhibits cell division in human non-small cell lung cancer via a CDC25A signaling mechanism. (PubMed, Exp Cell Res)
    This study's findings suggest that miR-100 can inhibit NSCLC progression by specifically targeting CDC25A, a cell cycle regulator, and its downstream molecular targets. Hence, miR-100 may have significant therapeutic potential against NSCLC.
    Journal
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    CCND1 (Cyclin D1) • CDK6 (Cyclin-dependent kinase 6) • MIR100 (MicroRNA 100) • CDC25A (Cell Division Cycle 25A) • E2F3 (E2F transcription factor 3) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)
    3ms
    PIK75 effectively reverses PI3K‒AKT activation caused by palbociclib resistance and synergistically inhibits the progression of esophageal squamous cell carcinoma. (PubMed, Sci Rep)
    The combined use of palbociclib and PIK75 synergistically inhibited the expression of the cell cycle proteins CCNE1, CDC6, and CDC25A, as well as the abnormal activation of PIK3CA and AKT phosphorylation. The combination of these two drugs synergistically inhibited tumor cell cycle progression and promoted apoptosis in vitro and in vivo, which provides a promising idea for the treatment of ESCC in the future.
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    PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • CCNE1 (Cyclin E1) • CDC25A (Cell Division Cycle 25A) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)
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    Ibrance (palbociclib) • PIK-75
    3ms
    Integrated Genomic and Transcriptomic Profiling of Isolated Trisomies in AML Reveals Cell Cycle Dysregulation and Therapeutic Vulnerabilities. (PubMed, J Cell Mol Med)
    Drug sensitivity profiling revealed subgroup-specific vulnerabilities: IT-8 to DNA damage checkpoint inhibitors, IT-21 to PLK/mTOR inhibitors and IT-13+22 to BRAF/EGFR-targeted agents. These findings highlight AML-IT heterogeneity and therapeutic potential.
    Journal
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    BRAF (B-raf proto-oncogene) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • DNMT3A (DNA methyltransferase 1) • ASXL1 (ASXL Transcriptional Regulator 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CALR (Calreticulin) • HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • MCM4 (Minichromosome Maintenance Complex Component 4) • CDC25A (Cell Division Cycle 25A) • CDC7 (Cell Division Cycle 7) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • HSP90AB1 (Heat Shock Protein 90 Alpha Family Class B Member 1)
    4ms
    Malate targets pyruvate kinase M2 to promote colorectal cancer cell cycle arrest and tumor suppression. (PubMed, Mol Biomed)
    Moreover, the expression of malate-metabolizing enzymes, MDH1 and FH, is significantly correlated with activity of the CDC25A/p-CDK1 signaling axis. Collectively, our results identify malate as a non-metabolic regulator of the cell cycle, operating through the PKM2-CDC25A-CDK1 pathway, and propose a novel therapeutic strategy targeting metabolic mediators of cell proliferation in cancer.
    Journal
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    CDK1 (Cyclin-dependent kinase 1) • CDC25A (Cell Division Cycle 25A) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • PKM (Pyruvate Kinase M1/2)
    5ms
    Identification and tissue-level validation of ferroptosis-related genes in small intestinal neuroendocrine neoplasms based on machine learning. (PubMed, BMC Gastroenterol)
    Four core ferroptosis-related genes (CDCA3, CDC25A, CYP4F8, and MYB) were identified in SI-NENs patients, which may aid in developing the diagnostic biomarkers and therapeutic targets in the clinic.
    Journal
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    CDCA3 (Cell Division Cycle Associated 3) • CDC25A (Cell Division Cycle 25A) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)