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GENE:

CDC20 (Cell Division Cycle 20)

News alerts, weekly reports and conference planners

Molecular insights for the tumor suppressor role of SPOP in prostate cancer. (PubMed, Biochim Biophys Acta Rev Cancer)

Hence, a deeper investigation into the molecular mechanisms of SPOP in prostate cancer will provide novel insights into its physiological function in oncogenesis and drug development. In this review, we summarize SPOP's tumor suppressor functions and structural features, upstream regulatory mechanisms, and SPOP-targeting therapeutic strategies in prostate cancer.

5 days ago

Review • Journal • PD(L)-1 Biomarker • IO biomarker

PD-L1 (Programmed death ligand 1) • SPOP (Speckle Type BTB/POZ Protein) • BRD4 (Bromodomain Containing 4) • CDC20 (Cell Division Cycle 20) • NCOA3 (Nuclear Receptor Coactivator 3)

12d

Exploratory transcriptomics and in vivo analyses of suramin in tongue squamous cell carcinoma. (PubMed, Biomed Rep)

Effect size estimates were relatively large for both the group effect (partial η2=0.20) and the time x group interaction (partial η2=0.24), suggesting that the study may have been underpowered to detect this difference statistically. In conclusion, the present exploratory study suggests that suramin exerts a dual antitumor effect on tongue squamous cell carcinoma by suppressing proliferative transcriptional programs, and modulating extracellular and stress response pathways, providing a basis for future studies to further elucidate its therapeutic relevance.

12 days ago

Preclinical • Journal

AURKA (Aurora kinase A) • FOXM1 (Forkhead Box M1) • CDC20 (Cell Division Cycle 20) • MYBL2 (MYB Proto-Oncogene Like 2) • TNFSF10 (TNF Superfamily Member 10) • TXNIP (Thioredoxin Interacting Protein) • CCNB1 (Cyclin B1) • TIMP3 (TIMP Metallopeptidase Inhibitor 3)

Germanin (suramin)

14d

Exploring the toxicological impact of N-nitrosodimethylamine (NDMA) exposure on bladder urothelial carcinoma (BLCA) through network toxicology, machine learning, and multi-dimensional bioinformatics analysis. (PubMed, Discov Oncol)

NDMA likely promotes BLCA through multi-target and multi-pathway mechanisms. The identified core genes serve as potential diagnostic biomarkers, and the proposed AOP provides a theoretical basis for environmental risk assessment and targeted intervention strategies.

14 days ago

Journal • IO biomarker

NRAS (Neuroblastoma RAS viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • IL7R (Interleukin 7 Receptor) • CDC20 (Cell Division Cycle 20)

24d

Integrative Bioinformatics and Experimental Validation Establish CCNB1 as a Potential Biomarker for Diagnosis and Prognosis in Colorectal Cancer. (PubMed, Curr Issues Mol Biol)

In vitro, CCNB1 knockdown triggered cell cycle arrest, thereby suppressing the proliferation of colorectal cancer cells. This study validated CCNB1 as a dual-purpose biomarker for CRC diagnosis and favorable prognosis, highlighting its potential utility in clinical management.

24 days ago

Journal

TOP2A (DNA topoisomerase 2-alpha) • CDCA3 (Cell Division Cycle Associated 3) • CCNA2 (Cyclin A2) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) • CDC20 (Cell Division Cycle 20) • KIF11 (Kinesin Family Member 11) • MCM4 (Minichromosome Maintenance Complex Component 4) • CCNB1 (Cyclin B1) • CDK3 (Cyclin Dependent Kinase 3) • CEP55 (Centrosomal Protein 55) • CKS2 (CDC28 Protein Kinase Regulatory Subunit 2) • CRYAB (Crystallin Alpha B) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MMP3 (Matrix metallopeptidase 3) • TPM2 (Tropomyosin 2) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)

2ms

Single-cell and machine learning-based analysis of the molecular mechanism of Banxia Xiexin Decoction in the treatment of gastric cancer. (PubMed, Cytotechnology)

We have established the correlation between the pathogenesis of GC's "cold and heat disorder" and modern pathological indicators (inflammation, oxidative damage, and cell apoptosis disorder) from the perspective of traditional Chinese medicine syndrome, providing a theoretical basis for the clinical application of BXXXD. The online version contains supplementary material available at 10.1007/s10616-025-00888-3.

2 months ago

Journal

CDC20 (Cell Division Cycle 20) • CDK1 (Cyclin-dependent kinase 1) • KIF11 (Kinesin Family Member 11) • KIF20A (Kinesin Family Member 20A) • KIF2C (Kinesin Family Member 2C)

2ms

Integrative high-throughput studies to develop novel targets and drugs for the treatment of advanced prostate cancer. (PubMed, Genes Dis)

These agents exhibited superior anti-tumor efficacy compared with AR antagonists in vitro. Our study identified novel prostate cancer therapeutic targets independent of the AR signaling pathway and established a research paradigm for developing anti-tumor agents through integrative cancer bioinformatics and network pharmacology analysis.

2 months ago

Journal

RB1 (RB Transcriptional Corepressor 1) • RRM2 (Ribonucleotide Reductase Regulatory Subunit M2) • CDC20 (Cell Division Cycle 20) • E2F1 (E2F transcription factor 1)

2ms

Structure-Based Virtual Screening Discovers Potent PLK1 Inhibitors with Anticancer Activity. (PubMed, J Chem Inf Model)

Importantly, follow-up kinase selectivity profiling revealed that BDE30671203 is a highly selective PLK1 inhibitor, showing over 450-fold and 1200-fold selectivity against the closely related AURKA and AURKB kinases, respectively. Therefore, this study not only provides promising chemical starting points for PLK1-targeted drug discovery, but more significantly validates a robust screening strategy for kinase inhibitor discovery.

2 months ago

Journal

BCL2 (B-cell CLL/lymphoma 2) • AURKA (Aurora kinase A) • PLK1 (Polo Like Kinase 1) • AURKB (Aurora Kinase B) • CDC20 (Cell Division Cycle 20) • CDK1 (Cyclin-dependent kinase 1)

2ms

Network-based insights into miR-30a-5p-mediated regulation and EGCG targeting in triple-negative breast cancer. (PubMed, Front Bioinform)

The results emphasizes that EGCG has strong binding affinity towards YWHAZ, revealing that miR-30a-EGCG targets TNBC synergistically through cell-cycle-mediated pathways. The findings give rational support for miRNA-guided phytochemical-based TNBC therapeutic development.

2 months ago

Journal

HER-2 (Human epidermal growth factor receptor 2) • PGR (Progesterone receptor) • PCNA (Proliferating cell nuclear antigen) • RRM2 (Ribonucleotide Reductase Regulatory Subunit M2) • CDC20 (Cell Division Cycle 20) • KIF11 (Kinesin Family Member 11) • ANLN (Anillin Actin Binding Protein) • CCNA1 (Cyclin A1) • MIR30A (MicroRNA 30a) • SKP2 (S-phase kinase-associated protein 2) • YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta)

HER-2 expression

2ms

Evaluation of crizotinib as radiosensitizer in sacral chordoma cells: effects of combined carbon ion particle therapy. (PubMed, Med Oncol)

The phosphorylation of key regulators involved in DNA repair and damage prevention, as well as MAPKs activated by C-ions irradiation, was partially inhibited by the combination treatment with crizotinib. While crizotinib shows promise as a therapeutic agent for sacral chordomas, its capacity to enhance radiosensitivity appears limited.

2 months ago

Journal

ALK (Anaplastic lymphoma kinase) • CDC20 (Cell Division Cycle 20)

Xalkori (crizotinib)

2ms

Overexpression of WDR77 also increased CDC20 protein levels. WDR77 serves as both a prognostic biomarker and functional regulator in melanoma, highlighting its potential as a therapeutic target.

2 months ago

Journal

CDC20 (Cell Division Cycle 20) • WDR77 (WD Repeat Domain 77)

CD20 positive

2ms

Exosome and BCR-ABL mediated molecular alterations in endothelial cells in chronic myeloid leukemia: identification of seven genes and their regulatory network. (PubMed, PeerJ)

A competing endogenous RNA (ceRNA) network involving miRNAs (e.g., miR-16-5p, miR-126-5p) and lncRNAs (e.g., AC008124.1, AC064799.2, AGAP11) potentially modulates their expression. This study identifies seven novel candidate biomarkers dysregulated in endothelial cells under combined BCR-ABL and exosomal stimulation, shedding light on the molecular crosstalk between leukemic cells and the vascular niche.

2 months ago

Journal

ABL1 (ABL proto-oncogene 1) • BCR (BCR Activator Of RhoGEF And GTPase) • CDC20 (Cell Division Cycle 20) • CDC25C (Cell Division Cycle 25C) • CREB1 (CAMP Responsive Element Binding Protein 1) • GRM1 (Glutamate Metabotropic Receptor 1) • MIR126 (MicroRNA 126) • MIR16 (MicroRNA 16) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)