CD9 KO cells were able to compensate the mitochondrial malfunction by increasing total mitochondrial mass reducing mitophagy. Our data thus provide the first evidence for a functional connection of tetraspanin CD9 with mitophagy in melanoma cells.
Finally, CD9 antibody showed anti-tumor effects in cell proliferation MTT assay, transwell migration assay and colony formation assay. Our study reveals a novel CD9/ADAM/Notch signaling network in PDAC and it supports that targeting CD9-ADAM interaction with antibody may be a potential therapeutic intervention for PDAC.
In a second melanoma model carrying a PD-1 resistant and highly aggressive tumour (SK-MEL5) AT1412 together with nivolumab was inducing full tumour rejection, while either one of the antibodies alone did not. Legal entity responsible for the study: The authors. Funding: AIMM Therapeutics.
4 years ago
Clinical
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CD8 (cluster of differentiation 8) • CD9 (CD9 Molecule)