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GENE:

CD81 (CD81 Molecule)

News alerts, weekly reports and conference planners

Glioblastoma Cells Expressing Oncogenic EGFR Release Multiple Extracellular Vesicle Subpopulations Positive or Negative for EGFR. (PubMed, J Extracell Biol)

Overall, our results suggest that multiple pathways of EV biogenesis may operate in glioma cells resulting in formation of complex EV landscapes consisting of EGFR-positive and EGFR-negative EV subsets. This heterogeneity may have important implications for EV functions and EV-based diagnostics.

2 days ago

Journal

EGFR (Epidermal growth factor receptor) • CD81 (CD81 Molecule)

EGFR expression • EGFR positive • EGFR negative

10d

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF-β signaling. (PubMed, FEBS J)

Accordingly, silencing RAB4A significantly increased the fusion of multivesicular bodies with the plasma membrane followed by EV secretion, suggesting that TGF-β-induced RAB4A acts as a negative feedback regulator of EV release. Our findings reveal a novel mechanism by which RAB4A modulates TGF-β-driven EV production by cancer cells.

10 days ago

Journal

TGFB1 (Transforming Growth Factor Beta 1) • CD81 (CD81 Molecule) • PDCD6IP (Programmed Cell Death 6 Interacting Protein) • TSG101 (Tumor Susceptibility 101)

10d

Utility of Urinary Extracellular Vesicles for Colorectal Cancer: Comparison of DNA Quality and MRD Detection. (PubMed, Cancer Sci)

These findings indicate that urinary EVs provide highly pure vesicles with superior DNA quality, making them a robust and completely non-invasive source for molecular profiling. Urinary EV-DNA-based MRD assessment shows significant prognostic value and may serve as a practical tool for postoperative monitoring and risk stratification in colorectal cancer.

10 days ago

Journal

BRAF (B-raf proto-oncogene) • RAS (Rat Sarcoma Virus) • CD9 (CD9 Molecule) • CD81 (CD81 Molecule)

BRAF mutation • RAS mutation

14d

AI-Guided Additive Scoring Model for Differential Diagnosis of Primary Liver Cancer. (PubMed, JHEP Rep)

Integrated EV and serological profiling may enable minimally invasive differentiation between HCC and iCCA within LR-M lesions. By transforming ML-guided model discovery into a clinically interpretable paper-and-pencil additive score, we illustrate a translational pathway from computational discovery to practical application.

14 days ago

Journal

CD9 (CD9 Molecule) • CA 19-9 (Cancer antigen 19-9) • CD81 (CD81 Molecule)

14d

Surface Plasmon Resonance as a Potential Diagnostic Tool for the Detection of CXC Chemokine Receptor 4 (CXCR4) on Extracellular Vesicles. (PubMed, Biosensors (Basel))

The BiacoreTM biosensor is able to directly detect and molecularly profile EVs in buffer and spiked in cell culture supernatant supplemented with 10% EV-depleted serum. Altogether, our findings illuminate the potential of SPR BiacoreTM technology in EV-related research as well as reveal the diagnostic potential of EV-associated CXCR4, offering valuable insights and paving the way for medical applications in diseases associated with aberrant CXCR4 expression.

14 days ago

Journal

CXCR4 (Chemokine (C-X-C motif) receptor 4) • CD9 (CD9 Molecule) • CD81 (CD81 Molecule)

24d

Human iPSC-derived exosomes for amelioration of Huntington's disease through mitochondrial, synaptic, and anti-apoptotic mechanisms. (PubMed, Biomed Pharmacother)

These multifaceted effects collectively alleviated mHtt aggregation, as confirmed by EM48 immunostaining and Western blot analysis. Together, our findings demonstrate that iPSC-exo mitigate HD pathology by improving mitochondrial function, neuronal differentiation, and anti-apoptotic signaling, thereby reducing mHtt accumulation.

24 days ago

Journal • IO biomarker

BCL2 (B-cell CLL/lymphoma 2) • NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CD81 (CD81 Molecule) • DLG4 (Discs Large MAGUK Scaffold Protein 4)

Exosomal Cannabidiol: A Promising Candidate for Targeted Oral Delivery against Breast Cancer. (PubMed, Cancer Lett)

TNBC cell lines MDA-MB-231 and taxol-resistant MDA-MB-231TR were sensitive to growth inhibition by CBD than estrogen receptor positive (ER+) MCF-7 and its taxol-resistant derivative MCF-7TR...These findings highlight the potential of FA-ExoCBD to enhance CBD's anticancer efficacy through targeted gene modulation. Overall, FA-ExoCBD improves CBD's therapeutic profile by enhancing efficacy, tumor selectivity, improved bioavailability and anticancer efficacy.

1 month ago

Journal

ER (Estrogen receptor) • ICAM1 (Intercellular adhesion molecule 1) • IL13RA2 (Interleukin 13 Receptor Subunit Alpha 2) • PRDM1 (PR/SET Domain 1) • CD81 (CD81 Molecule)

ER positive

paclitaxel

Exosomal LINC01614 from Gastric Cancer Cells Drives Treg Differentiation. (PubMed, J Vis Exp)

At the mechanistic level, the RIP assay (anti-IL-4 antibody pull-down) suggests that LINC01614 may directly interact with IL-4. In summary, this study preliminarily reveals the mechanism by which LINC01614 promotes Treg differentiation and M2 polarization through the exosome pathway to regulate the immune microenvironment of gastric cancer, providing a theoretical basis for targeting LINC01614 to enhance immunotherapy.

1 month ago

Journal • IO biomarker

IL2RA (Interleukin 2 receptor, alpha) • CD4 (CD4 Molecule) • TGFB1 (Transforming Growth Factor Beta 1) • FOXP3 (Forkhead Box P3) • GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) • IL4 (Interleukin 4) • CD81 (CD81 Molecule) • TSG101 (Tumor Susceptibility 101)

LE 8201: Leniolisib for immune dysregulation in CVID (2024-517725-93-00)

P1/2, N=6, Active, not recruiting, Pharming Technologies B.V. | Recruiting --> Active, not recruiting

1 month ago

Enrollment closed

PTEN (Phosphatase and tensin homolog) • CD20 (Membrane Spanning 4-Domains A1) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • IKZF1 (IKAROS Family Zinc Finger 1) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • CARD11 (Caspase Recruitment Domain Family Member 11) • NFKB2 (Nuclear Factor Kappa B Subunit 2) • TNFRSF13C (TNF Receptor Superfamily Member 13C) • CD81 (CD81 Molecule) • SEC61A1 (SEC61 Translocon Subunit Alpha 1) • TNFRSF13B (TNF Receptor Superfamily Member 13B)

A One-Step Workflow for Size-Based Separation of Extracellular Vesicles With Integrated Surface Marker Detection. (PubMed, J Extracell Biol)

Proof-of-concept was gained for the detection of PSMA-positive EVs in urine from prostate cancer patients and discrimination of breast cancer patients from healthy donors by quantifying EpCAM- or HER2-positive EVs in blood plasma. In conclusion, using low-volume biofluids, the one-step AF4-MALS-FLD workflow holds potential for fast and robust EV biomarker detection.

1 month ago

Journal

HER-2 (Human epidermal growth factor receptor 2) • EPCAM (Epithelial cell adhesion molecule) • CD9 (CD9 Molecule) • CD81 (CD81 Molecule)

HER-2 positive • FOLH1 positive

Mesenchymal Stem Cell Exosome-Mediated Delivery of Paclitaxel for Pancreatic Cancer Therapy. (PubMed, Biomolecules)

These findings demonstrate that MSC-derived exosomes can efficiently encapsulate and deliver PTX, enhancing its antitumor efficacy. This exosome-based platform offers a promising strategy to overcome pharmacological barriers and improve therapeutic outcomes in PDAC.

1 month ago

Journal

THY1 (Thy-1 membrane glycoprotein) • CD81 (CD81 Molecule)

paclitaxel

Molecular Characterization of Extracellular Vesicles From Human B Cell Lymphomas: Methodological Comparison to Vesicles From Patient Serum. (PubMed, J Extracell Biol)

Also, to successfully detect markers, e.g. Hsp70 or CD44, in serum EVs we demonstrated to require more intense sample preparation in specific assays. While more patient studies are needed in the future, this pilot study paves the way for understanding the molecular differences in the DLBCL subtypes and for detecting them in the lymphoma EVs.

1 month ago

Journal

CD9 (CD9 Molecule) • CD81 (CD81 Molecule)