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    BIOMARKER:

    CD58 expression

    i
    Other names: CD58, CD58 Molecule, CD58 Antigen, (Lymphocyte Function-Associated Antigen 3), Lymphocyte Function-Associated Antigen 3, Surface Glycoprotein LFA-3, LFA3, Ag3, CD58 Antigen, LFA-3
    Entrez ID:
    965
    Related biomarkers:
    Mutation
    8ms
    Clinical significance of immune-related antigen CD58 in gliomas and analysis of its potential core related gene clusters. (PubMed, Heliyon)
    High CD58 expression is correlated with more malignant glioma types, and also an independent risk factor for mortality in glioma. CD58 and its core-related genes may serve as novel biomarkers for diagnosing and treating glioma.
    Journal
    |
    MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • CCL2 (Chemokine (C-C motif) ligand 2) • IL18 (Interleukin 18) • CD58 (CD58 Molecule) • TLR2 (Toll Like Receptor 2)
    |
    CD58 expression
    8ms
    CD58 alterations govern antitumor immune responses by inducing PD-L1 and IDO in diffuse large B-cell lymphoma. (PubMed, Cancer Res)
    Notably, CD58 genetic alterations, along with low CD58 expression, significantly correlated with reduced rates of response to R-CHOP therapy and inferior progression-free and overall survival...Direct activation of CD58-CD2 costimulatory signaling in combination with anti-PD-L1 blockade or IDO inhibitor sensitized CD58-deficient DLBCL to CAR T-cell therapy. Collectively, this work identified the multiple roles of CD58 in regulating antitumor immune responses in DLBCL.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • CD22 (CD22 Molecule) • LYN (LYN Proto-Oncogene Src Family Tyrosine Kinase) • CD58 (CD58 Molecule) • CD2 (CD2 Molecule)
    |
    PD-L1 expression • IDO1 expression • CD58 expression • CD58 mutation
    |
    Rituxan (rituximab)