B3GAT1 (Beta-1,3-Glucuronyltransferase 1)

In particular, HLA-B leader matched patients had a higher CD57 expression of total NK and NKG2A+KIR- NK cells, with enhanced NKG2A+KIR- NK cell cytotoxicity (CD107a expression) and IFN-γ secretion at 1, 3, and 6 months post-transplantation (all false discovery rate-adjusted P <0.05). These findings identify HLA-B leader matching status as a disease-specific prognostic biomarker, suggesting its potential relevance for personalized donor selection considerations in haplo-HSCT settings.

These findings suggest that CD57+ NK cells and CD138+ plasma cells may contribute to the prognostic landscape of CHL. Understanding the functional roles of these cells within the TME may enable more personalized and immune-informed strategies for CHL patients.

In conclusion, acute HIIT mobilizes functional, virus-reactive CD8+ T cells with features indicative of enhanced migratory and activation potential, supporting translational use from tumor immunology to infectious disease. The study is registered at clinicaltrials.gov (NCT05826496).

P2, N=30, Recruiting, Jonathan Brammer | Trial completion date: Dec 2025 --> Jul 2026 | Trial primary completion date: Dec 2025 --> Jul 2026

Our results concluded that the CD57 biomarker gives the impression of being a good indicator of the immune status of the patient and the aggressiveness of the lesion. Results can be improvised in future studies with increased sample size and clinical correlation.

These findings demonstrate that exercise-induced NK mobilization combined with cytokine pre-activation yields an adoptive cell therapy product with superior anti-leukemic activity. (NCT06643221).

Our study described the characteristics of composite renal tumors combining WT and RCC, highlighting several unusual and specific features. Its behavior appeared to be more aggressive than that of WT or RCC alone, and we propose that it should be recognized as a separate entity, which may require different treatment from WT or RCC alone.

The differences in clinical features and laboratory tests between patients with ANKL and CLPD-NK aid in the diagnosis of ANKL. CRP and Fib levels can be used to predict the prognosis of patients, and combined asparaginase therapy can enhance the overall survival of patients.

Integrating ascitic immunophenotyping with clinical factors improves risk prediction in HGSOC, with RSF offering robust performance under rigorous, leakage-safe validation. Ascites-resident T-cell states provide complementary, reproducible prognostic signals for survival and platinum response, supporting their potential utility for patient stratification and hypothesis generation for immunomodulatory strategies.

In BJAB B cells, HSUR1 still drives PRE-dependent gene regulation, but the affected genes only partially overlap with those in Jurkat cells, and some transcripts even show reversed direction of change, revealing strong cell-type specificity. By identifying PUM1/2 as key host partners of HSUR ncRNAs, this work uncovers an underappreciated role for PUM proteins in shaping T- and B-cell states and reveals an additional way in which γ -herpesviral ncRNAs reprogram lymphocytes to promote viral persistence.

These immunological differences likely reflect different disease pathogenesis mechanisms occurring in the two clinical groups, opening up opportunities for the development of prognostic markers and stratified treatments.

FACS analysis showed loss of co-stimulatory CD80, an immune synapse component, following B3gat1 knockdown. These results suggest that loss of HNK-1 expression contributes to tumor immune escape through loss of immune recognition and attack via downregulation of tumor cell surface co-stimulatory molecules, leading to reduced CD8+ T-cell activation and immune synapse formation, and increased T-cell apoptosis.