News - CD44 expression

Extracellular vesicles containing circMYBL1 induce CD44 in adenoid cystic carcinoma cells and pulmonary endothelial cells to promote lung metastasis. (PubMed, Cancer Res)

Moreover, circMYBL1 encapsulated in sEVs increased the arrest of circulating ACC cells in the lung and enhanced the lung metastatic burden. This data suggests that circMYBL1 is a tumor-promoting circRNA that could serve as a potential biomarker and therapeutic target in ACC.

1 day ago

Journal

CD44 (CD44 Molecule) • MYBL1 (MYB Proto-Oncogene Like 1)

CD44 expression

Beta hydroxybutyrate induces lung cancer cell death, mitochondrial impairment and oxidative stress in a long term glucose-restricted condition. (PubMed, Mol Biol Rep)

The induced cell death, oxidative stress and mitochondria impairment beside attenuated levels of cancer stem cell markers following BHB administration emphasize on the distinctive role of metabolic plasticity of cancer cells and propose possible therapeutic approaches to control cancer cell growth through metabolic fuels.

1 day ago

Journal

CTNNB1 (Catenin (cadherin-associated protein), beta 1) • CD44 (CD44 Molecule)

CD44 expression • CD133 expression • SOX9 expression

Decorin suppresses stemness and migration potential of malignant peripheral nerve sheath tumor through inhibiting epidermal growth factor receptor signaling. (PubMed, Biochim Biophys Acta Mol Basis Dis)

Decorin-negative MPNST cells grew significantly larger tumor in vivo. Thus, depletion of Decorin may occur in CSCs in MPNSTs, serving possibly as a new therapeutic target.

2 days ago

Journal

EGFR (Epidermal growth factor receptor) • CD44 (CD44 Molecule) • DCN (Decorin)

CD44 expression • CD133 expression • CD133 positive • CD44 positive

Associations of early-life and adult anthropometric measures with the expression of stem cell markers CD44, CD24, and ALDH1A1 in women with benign breast biopsies. (PubMed, Cancer Epidemiol Biomarkers Prev)

Anthropometric measures, such as birthweight, height, and childhood body fatness, may have long-term impacts on stem cell population in the breast.

2 days ago

Journal • Biopsy

CD44 (CD44 Molecule) • CD24 (CD24 Molecule) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1)

CD44 expression • CD24 expression

Construction of glutathione-responsive paclitaxel prodrug nanoparticles for image-guided targeted delivery and breast cancer therapy. (PubMed, RSC Adv)

Moreover, the prodrug NPs also shown superior anti-tumor effects in vivo experimental. Overall, the HA/TPE-CS-SS-PTX NPs we constructed have excellent bio-imaging capabilities and can be served as a potential nanomedicine for PTX delivery against breast cancer.

4 days ago

Journal

CD44 (CD44 Molecule)

CD44 expression

paclitaxel

POLE2 promotes osteosarcoma progression by enhancing the stability of CD44. (PubMed, Cell Death Discov)

Moreover, knockdown of CD44 inhibited the tumor-promoting effects of POLE2 overexpression on OS cells. In conclusion, POLE2 augmented the expression of CD44 via inhibiting MDM2-mediated ubiquitination, and then activated Rac signaling pathway to influence the progression of OS, indicating that POLE2/CD44 might be potential targets for OS treatment.

9 days ago

Journal

CD44 (CD44 Molecule)

CD44 expression

10d

Effect of LAG3 deficiency on natural killer cell function and hepatic fibrosis in mice infected with Echinococcus multilocularis (PubMed, Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi)

During the course of E. multilocularis infections, LAG3-/- promotes high-level secretion of IFN-γ by splenic NK cells, which may participate in the reversal the immune function of NK cells, resulting in aggravation of hepatic fibrosis.

10 days ago

Preclinical • Journal • IO biomarker

IFNG (Interferon, gamma) • LAG3 (Lymphocyte Activating 3) • TNFA (Tumor Necrosis Factor-Alpha) • IL2RA (Interleukin 2 receptor, alpha) • CD44 (CD44 Molecule) • CD69 (CD69 Molecule) • IL10 (Interleukin 10) • IL17A (Interleukin 17A) • IL4 (Interleukin 4) • ISG20 (Interferon Stimulated Exonuclease Gene 20)

CD44 expression

11d

A paclitaxel-hyaluronan conjugate (ONCOFID-P-B™) in patients with BCG-unresponsive carcinoma in situ of the bladder: a dynamic assessment of the tumor microenvironment. (PubMed, J Exp Clin Cancer Res)

The clinical response to ONCOFID-P-B™ in bladder CIS likely relies on several components of the TME, and the combined evaluation of intra-tumoral macrophages density and CD44v6 expression is a potentially new predictive biomarker for patient response. Overall, our data allow to advance a potential rationale for combinatorial treatments targeting the immune infiltrate such as immune checkpoint inhibitors, to make bladder CIS more responsive to ONCOFID-P-B™ treatment.

11 days ago

Journal • IO biomarker

CD8 (cluster of differentiation 8) • ICAM1 (Intercellular adhesion molecule 1)

CD44 expression

paclitaxel • Oncofid-P (paclitaxel-hyaluronic acid conjugate)

15d

PHD finger protein 10 promotes cell proliferation by regulating CD44 transcription in gastric cancer. (PubMed, Heliyon)

This effect could be associated with BRG, BAF155 and SNF5, which were conserved subunits of switch/sucrose non-fermentable (SWI/SNF) complex. In conclusion, PHF10 targeting CD44 plays an essential part during the modulation of proliferation of GC cell and may offer a new therapeutic direction for GC.

15 days ago

Journal

CD44 (CD44 Molecule) • TRPS1 (Transcriptional Repressor GATA Binding 1)

CD44 expression

17d

Pan-cancer and single-cell analyses identify CD44 as an immunotherapy response predictor and regulating macrophage polarization and tumor progression in colorectal cancer. (PubMed, Front Oncol)

Knockdown of CD44 inhibited M2 macrophage polarization. These findings suggest that CD44 is involved in regulating tumor development, macrophage polarization, and has certain predictive value for patient clinical prognosis and response to immunotherapy.

17 days ago

Journal • IO biomarker • Pan tumor

CD44 (CD44 Molecule)

CD44 expression

20d

Investigation of the feasibility of NRAV as a biomarker for hepatocellular carcinoma. (PubMed, Oncol Res)

The inhibition of NRAV resulted in the inhibition of cell proliferation, migration, and invasion in HCC cells, while also influencing the expression of CD274 (PD-L1) and CD44, along with various biomarkers associated with EMT, autophagy, and pyroptosis. The aforementioned results propose NRAV as a promising prognostic biomarker for HCC.

20 days ago

Journal • Tumor mutational burden • PD(L)-1 Biomarker • IO biomarker

PD-L1 (Programmed death ligand 1) • TMB (Tumor Mutational Burden) • MSI (Microsatellite instability)

PD-L1 expression • CD44 expression

21d

Associations of reproductive breast cancer risk factors with expression of stem cell markers in benign breast tissue. (PubMed, Front Oncol)

In postmenopausal women, lifetime duration of breastfeeding was inversely associated with stromal ALDH1A1 expression (β for ≥24 vs. 0 to <1 months = -2.24, 95% CI 3.96; -0.51, p-trend = 0.01). Early-life reproductive factors may influence CD44 and ALDH1A1 expression in benign breast tissue.

21 days ago

Journal

CD44 (CD44 Molecule) • CD24 (CD24 Molecule) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1)

CD44 expression

22d

Exploring the Potentials of Hyaluronic Acid-coated Polymeric Nanoparticles in Enhanced Cancer Treatment by Precision Drug Delivery, Tackling Drug Resistance, and Reshaping the Tumour Micro Environment. (PubMed, Curr Med Chem)

The study describes production, clinical trials, and problems and prospects in turning HA-coated PNP platforms into viable therapeutic nanomedicines. HA-functionalized PNPs are versatile, targeted nanotherapeutics for various tumor types and disease stages, as shown in this comprehensive study.

22 days ago

Journal

CD44 (CD44 Molecule)

CD44 expression

22d

Methylation study of tumor suppressor genes in human aberrant crypt foci, colorectal carcinomas, and normal colon. (PubMed, J Cancer Res Ther)

Early epigenetic methylation of WIF1 gene is one of the mechanisms for ACF development in human colon.

22 days ago

Journal

CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • MLH1 (MutL homolog 1) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • CD44 (CD44 Molecule) • RASSF1 (Ras Association Domain Family Member 1) • WIF1 (WNT Inhibitory Factor 1)

CD44 expression • CD44 positive • RASSF1 methylation

23d

Anti-IL-8 monoclonal antibodies inhibits the autophagic activity and cancer stem cells maintenance within breast cancer tumor microenvironment. (PubMed, Breast Dis)

While it caused a non-significant decrease in CD24 expression in cultured breast tumor tissue and a significant decrease in its expression in the corresponding normal ones. Anti-IL-8 monoclonal antibody exhibits promising immunotherapeutic properties through targeting both autophagy and CSCs maintenance within breast cancer TME.

23 days ago

Journal • Cancer stem • IO biomarker

CXCL8 (Chemokine (C-X-C motif) ligand 8) • CD44 (CD44 Molecule) • CD24 (CD24 Molecule)

CD44 expression • CD24 expression

25d

Role of CD44 in Chemotherapy Treatment Outcome: A Scoping Review of Clinical Studies. (PubMed, Int J Mol Sci)

In summary, this scoping review highlighted the breadth of the available literature investigating the clinical association between CD44 and chemotherapeutic outcomes. Further research is required to elucidate this relationship to aid clinicians in managing CD44-positive cancer patients.

25 days ago

Review • Journal

CD44 (CD44 Molecule)

CD44 expression • CD44 positive

25d

EIF2Ss, a Novel c-Myc-Correlated Gene Family, is Associated with Poor Prognosis and Immune Infiltration in Pancreatic Adenocarcinoma. (PubMed, Front Biosci (Landmark Ed))

EIF2Ss were found to have significant clinical implications for the prognosis and treatment of PAAD. Inhibition of c-myc caused the downregulation of EIF2S1, EIF2S2, and EIF2S3 expression.

25 days ago

Journal

MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CD276 (CD276 Molecule) • CD73 (5'-Nucleotidase Ecto) • NT5E (5'-Nucleotidase Ecto) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha) • ULBP1 (UL16 Binding Protein 1)

MYC expression • CD44 expression

26d

Modeling 5-FU-Induced Chemotherapy Selection of a Drug-Resistant Cancer Stem Cell Subpopulation. (PubMed, Curr Oncol)

(2) The expression of markers CD24, CD44, ALDH1, and ABCG2 was analyzed on the surface of CSCs in two cancer cell lines, MDA-MB-231 and HCT-116, after treatment with 5-fluorouracil (5-FU) using flow cytometry analysis...(4) Each individual GA prediction model achieved high accuracy in estimating the expression rate of CSC markers on cancer cells treated with 5-FU. Artificial intelligence can be used as a powerful tool for predicting drug resistance.

26 days ago

Journal • Cancer stem

ABCG2 (ATP Binding Cassette Subfamily G Member 2) • CD44 (CD44 Molecule) • CD24 (CD24 Molecule) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1)

CD44 expression • CD24 expression

5-fluorouracil

29d

The necroptosis-related signature and tumor microenvironment immune characteristics associated with clinical prognosis and drug sensitivity analysis in stomach adenocarcinoma. (PubMed, Aging (Albany NY))

This investigation provides a robust methodological advance in prognosticating and personalizing immunotherapy for STAD, leveraging quantitatively derived tumor cluster risk scores. It posits the use of necroptosis-related lncRNAs as pivotal molecular beacons for guiding therapeutic strategies and enhancing clinical outcomes in STAD.

29 days ago

Journal • IO biomarker

CD44 (CD44 Molecule)

CD44 expression

29d

Gene-Expression Patterns of Tumor and Peritumor Tissues of Smoking and Non-Smoking HPV-Negative Patients with Head and Neck Squamous Cell Carcinoma. (PubMed, Biomedicines)

The largest group included 10 genes: TIMP1, TIMP2, WEE1, YAP, HIF1A, PI3KCA, UTP14A, APIP, PTEN, and SLC26A6. The genetic signatures associated with smoking habits that we have found may serve as a prerequisite for the development of diagnostic panels/tests predicting responses to different therapeutic strategies for HNSCC.

29 days ago

Journal

EGFR (Epidermal growth factor receptor) • PTEN (Phosphatase and tensin homolog) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • IL6 (Interleukin 6) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • TIMP1 (Tissue inhibitor of metalloproteinases 1) • KRT17 (Keratin 17) • TIMP2 (TIMP Metallopeptidase Inhibitor 2) • TP63 (Tumor protein 63)

EGFR expression • CD44 expression • HIF1A expression • IL6 expression

CD44 and CD133 protein expression might serve as a prognostic factor for early occurrence castration-resistant prostate cancer. (PubMed, Prostate)

This study found a low expression of at least one CD44/CD133 protein in the patients without early occurrence of CRPC. This result might suggest that CD44/CD133 may function as a potential prognostic marker for PCa, especially in a low expression, to identify patients who have a better prognosis regarding the occurrence of early CRPC.

1 month ago

Journal

CD44 (CD44 Molecule)

CD44 expression • CD133 expression

HMOX1 regulates ferroptosis via mic14 and its impact on chemotherapy resistance in small-cell lung cancer. (PubMed, Anticancer Drugs)

mic14 exhibited inhibitory effects on cellular lipid peroxidation in SCLC cells and contributed to reduced chemosensitivity and increased drug resistance in chemoresistant SCLC cell lines. HMOX1 plays a role in ferroptosis by regulating mic14 expression, thereby reversing chemoresistance in SCLC.

1 month ago

Journal

HMOX1 (Heme Oxygenase 1) • GPX4 (Glutathione Peroxidase 4) • TFRC • ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) • FTL (Ferritin Light Chain) • RMC1 (Regulator Of MON1-CCZ1)

CD44 expression • GPX4 expression • HMOX1 expression • HMOX1 overexpression

Scutellarin, a flavonoid compound from Scutellaria barbata, suppresses growth of breast cancer stem cells in vitro and in tumor-bearing mice. (PubMed, Phytomedicine)

Our study demonstrated for the first time that both SB water extract and scutellarin could reduce the proliferation and migration of BCSCs in vitro. Scutellarin was shown to possess novel inhibitory activities in BCSCs progression. These findings suggest that Scutellaria barbata water extract, in particular, scutellarin, may have potential to be further developed as an adjuvant therapy for reducing breast cancer recurrence.

1 month ago

Preclinical • Journal • Cancer stem

PTEN (Phosphatase and tensin homolog) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • CD44 (CD44 Molecule) • CD24 (CD24 Molecule) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1)

CD44 expression • CD133 expression

DOT1L promotes expression of CD44 through the Wnt/β-catenin signaling pathway in early gastric carcinoma. (PubMed, J Cancer)

In addition, we found that DOT1L, CD44 and CTNNB1 colocalize and correlate positively. In conclusion, one important CSC regulator in GC, DOT1L may be crucial in coordinating the expression of genes specific to a certain lineage during MSC development.

1 month ago

Journal

CD44 (CD44 Molecule) • DOT1L (DOT1 Like Histone Lysine Methyltransferase)

CD44 expression

CD44-Based Detection of CSCs: CD44 Immunodetection by Flow Cytometry. (PubMed, Methods Mol Biol)

Here we detail CD44 detection by flow cytometry, a precise technique allowing to determine the percentage of positive cells and the mean fluorescent intensity reflecting the CD44 expression by cells in the samples. The protocol explained here can be used to detect CD44 from cell suspensions prepared from tissues or in vitro cell cultures.

1 month ago

Journal

CD44 (CD44 Molecule)

CD44 expression

GTP binding protein 2 maintains the quiescence, self-renewal, and chemoresistance of mouse colorectal cancer stem cells via promoting Wnt signaling activation. (PubMed, Heliyon)

GTPBP2 deficiency caused the following effects on CCSCs: 1) Significantly accelerating proliferation and increasing the proportions of cells at G1, S, and G2/M phase; 2) Impairing resistance to 5-Fluorouracil; 3) Weakening self-renewal but not impacting cell migration...Collectively, this study indicates that GTPBP2 positively modulates Wnt signaling to reinforce the quiescence, self-renewal, and chemoresistance of mouse CCSCs. Therefore, we disclose a novel mechanism underlying CCSC biology and GTPBP2 could be a therapeutic target in future CRC treatment.

1 month ago

Preclinical • Journal • Cancer stem

CTNNB1 (Catenin (cadherin-associated protein), beta 1)

CD44 expression • CD133 expression

5-fluorouracil

2ms

Myelodysplastic neoplasms dissected into indolent, leukaemic and unfavourable subtypes by computational clustering of haematopoietic stem and progenitor cells. (PubMed, Leukemia)

The proliferation of haematopoietic stem cells and common myeloid progenitors with downregulated CD44 expression, suggestive of impaired haematopoietic differentiation, characterised a distinct MDS subtype with a poor overall survival. This exploratory study demonstrates the prognostic value of known and previously unexplored CD34+ populations and suggests the feasibility of dissecting MDS into a more indolent, a leukaemic and another unfavourable subtype.

2 months ago

Journal

CD44 (CD44 Molecule) • CD34 (CD34 molecule)

CD44 expression

2ms

Vitamin D suppresses CD133+/CD44 + cancer stem cell stemness by inhibiting NF-κB signaling and reducing NLRP3 expression in triple-negative breast cancer. (PubMed, Cancer Chemother Pharmacol)

Findings elucidate that VD mediates the modulation of stemness in CD133+/CD44 + breast cancer stem cells through the regulation of NLRP3 expression. The research represents novel insights on the implications for the application of VD in cancer therapies.

2 months ago

Journal • Cancer stem

CD44 (CD44 Molecule) • SOX2 • POU5F1 (POU Class 5 Homeobox 1) • NLRP3 (NLR Family Pyrin Domain Containing 3) • RELA (RELA Proto-Oncogene) • VDR (Vitamin D Receptor)

CD44 expression • CD133 expression • SOX2 expression • POU5F1 expression

2ms

A landscape of patient-derived cancer-associated fibroblast signals in endometrial cancers. (PubMed, Am J Cancer Res)

We demonstrate that endometrial CAFs can be cultured in an enzymatic-digestion-independent manner, and their signaling landscape can be mapped toward understanding CAF-TME dialogue. Our data will help unearth the functional relevance of endometrial CAFs in the context of clinical outcomes and designing CAF-inclusive therapy in the future.

2 months ago

Journal • PD(L)-1 Biomarker • IO biomarker

PD-L1 (Programmed death ligand 1) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • CD8 (cluster of differentiation 8) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • EPCAM (Epithelial cell adhesion molecule) • VIM (Vimentin) • FAP (Fibroblast activation protein, alpha) • PVR (PVR Cell Adhesion Molecule) • CD31 (Platelet and endothelial cell adhesion molecule 1) • THY1 (Thy-1 membrane glycoprotein) • MMP1 (Matrix metallopeptidase 1) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • S100A4 (S100 calcium binding protein A4)

CD8 positive • CD44 expression • CXCL12 expression • VIM expression • EPCAM expression

2ms

Potential role of lymphocyte CD44 in determining treatment selection between stereotactic body radiotherapy and surgery for early-stage non-small-cell lung cancer. (PubMed, Int J Radiat Oncol Biol Phys)

Lymphocyte CD44 may not only be a predictor of SBRT efficacy in this population, but also an important biomarker (pending validation by large prospective data) that could better sharpen selection for SBRT vs. surgery in ES-NSCLC.

2 months ago

Journal • Surgery

CD44 (CD44 Molecule) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • CD68 (CD68 Molecule)

CD44 expression

2ms

Frequency of cd44 expression in diagnosed cases of oral Epithelial dysplasia and squamous cell carcinoma. (PubMed, J Ayub Med Coll Abbottabad)

Among 41 cases of dysplasia, 36 showed membranous positivity for CD44 (87.8%), and 45 showed positive membranous CD44 immunoreactivity (83.3%) among 54 cases of squamous cell carcinoma. Increased frequency of CD44 expression was found with increasing grades of dysplasia and squamous cell carcinoma, which may be a possible indicator of malignant transformation and can serve as a prognostic biomarker for oral SCC.

2 months ago

Journal

CD44 (CD44 Molecule)

CD44 expression

2ms

VGLL1 stabilization of cytoplasmic TAZ promotes EGFR expression and maintains tumor initiating cells in breast cancer independent of TEAD. (PubMed, Cell Signal)

In addition, we observed that VGLL1 represses AXL expression and suppresses claudin-low phenotype, and that is caused by the VGLL1 mediated nuclear expulsion of TAZ. Therefore, EGFR and AXL seem to represent two different breast tumor subtypes, and their differential expressions is controlled by VGLL1.

2 months ago

Journal

EGFR (Epidermal growth factor receptor) • AXL (AXL Receptor Tyrosine Kinase) • CD24 (CD24 Molecule) • TAFAZZIN (Tafazzin)

EGFR expression • AXL expression • CD44 expression • CD24 expression

2ms

Role of CD44 and CD24 Expression on 2-years Disease Free Survival in Patients with Advanced Epithelial Ovarian Carcinoma. (PubMed, Asian Pac J Cancer Prev)

High expression of CD44 and CD24 will shorten the disease-free survival of patients with advanced ovarian cancer.

2 months ago

Journal • Metastases

CD44 (CD44 Molecule) • CD24 (CD24 Molecule)

CD44 expression • CD24 expression

2ms

A Proteomic Investigation to Discover Candidate Proteins Involved in Novel Mechanisms of 5-Fluorouracil Resistance in Colorectal Cancer. (PubMed, Cells)

Validation through immunodetection techniques confirmed high expression of CD44 and CD63, two known drug resistance mediators with elevated proteomics expression results. The information revealed by the sensitivity of this method warrants it as an important tool for elaborating the complexity of acquired drug resistance in CRC.

2 months ago

Journal

CD44 (CD44 Molecule) • AGR2 (Anterior gradient 2) • CD55 (CD55 Molecule) • RBMS2 (RNA Binding Motif Single Stranded Interacting Protein 2)

CD44 expression

5-fluorouracil

2ms

Kurarinone targets JAK2-STAT3 signaling in colon cancer-stem-like cells. (PubMed, Cell Biochem Funct)

In conclusion, KU treatment decreases stemness/self-renewal, induces cell cycle arrest and apoptosis in HCT-116 colonosphere by down-regulating CD44-JAK2-STAT3 axis. Thus, targeting stemness/self-renewal and other cancer hallmark(s) by KU through CD44/JAK2/STAT3 signaling pathway might be a novel strategy to target colon cancer stem-like cells.

2 months ago

Journal • PARP Biomarker • IO biomarker

MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • CCND1 (Cyclin D1) • CDK4 (Cyclin-dependent kinase 4) • CD44 (CD44 Molecule) • SOX2 • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • BMI1 (BMI1 proto-oncogene, polycomb ring finger)

MYC expression • CCND1 expression • CD44 expression

2ms

Blocking EGR1/TGF-β1 and CD44s/STAT3 Crosstalk Inhibits Peritoneal Metastasis of Gastric Cancer. (PubMed, Int J Biol Sci)

The blocking effect of SHR-1701 on TGF-β1 was verified by inhibiting peritoneal metastases in xenografts. Collectively, the interplay of EGR1/TGF-β1/CD44s/STAT3 signaling between mesothelial cells and GC cells induces EMT and stemness phenotypes, offering potential as a therapeutic target for PM of GC.

2 months ago

Journal

STAT3 (Signal Transducer And Activator Of Transcription 3) • TGFB1 (Transforming Growth Factor Beta 1) • EGR1 (Early Growth Response 1)

CD44 expression

retlirafusp alfa (SHR-1701)

2ms

Bortezomib-loaded immunoliposomes against CD44 expressing macrophages: an interplay for inflammation resolution. (PubMed, Nanoscale)

JNK1/2 activation may lead to the release of mitochondrial pro-apoptotic factors, triggering the intrinsic apoptotic pathway and activation of caspases, which was confirmed from the level of apoptotic gene and protein expression. The precise targeting and anti-inflammatory action of this therapy against macrophages hold promise for therapeutic interventions in a wide range of inflammatory conditions, offering a novel avenue for precision medicine in the battle against excessive inflammation.

2 months ago

Journal

CD44 (CD44 Molecule) • MAPK8 (Mitogen-activated protein kinase 8)

CD44 expression

bortezomib

2ms

SALL4 promotes cancer stem-like cell phenotype and radioresistance in oral squamous cell carcinomas via methyltransferase-like 3-mediated m6A modification. (PubMed, Cell Death Dis)

Mechanistically, we illustrated that SALL4 is a direct downstream transcriptional regulation target of METTL3, the transcription activation of SALL4 promotes the nuclear transport of β-catenin and the expression of downstream target genes after radiation therapy, there by activates the Wnt/β-catenin pathway, effectively enhancing the CSCs phenotype and causing radioresistance. Herein, this study indicates that the METTL3/SALL4 axis promotes the CSCs phenotype and resistance to radiation in OSCC via the Wnt/β-catenin signaling pathway, and provides a potential therapeutic target to eliminate radioresistant OSCC.

2 months ago

Journal

CD44 (CD44 Molecule) • SALL4 (Spalt Like Transcription Factor 4) • METTL3 (Methyltransferase Like 3) • TCF4 (Transcription Factor 4)

CD44 expression • SALL4 overexpression

2ms

Involvement of Cyclooxygenase-2 in Establishing an Immunosuppressive Microenvironment in Tumorspheres Derived from TMZ-Resistant Glioblastoma Cell Lines and Primary Cultures. (PubMed, Cells)

We previously reported that COX-2 upregulation induced by temozolomide (TMZ) supported chemoresistance...The presence of macrophages U937 within tumorspheres derived from GBM cell lines and primary cultures exposed to celecoxib (COX-2 inhibitor) with or without TMZ was studied by confocal microscopy...Remarkably, exogenous prostaglandin-E2 restored OPN and CD44, highlighting the COX-2 pivotal role in the protumor macrophages' state promotion. COX-2 inhibition interfered with TMZ's ability to induce M2-polarization and counteracted the development of an immunosuppressive TME.

2 months ago

Preclinical • Journal

CD44 (CD44 Molecule) • SPP1 (Secreted Phosphoprotein 1) • TGFB1 (Transforming Growth Factor Beta 1) • MRC1 (Mannose Receptor C-Type 1)

CD44 expression

temozolomide • celecoxib oral

2ms

Tumor volume and cancer stem cell expression as prognostic markers for high-dose loco-regional failure in head and neck squamous cell carcinoma - a DAHANCA 19 study. (PubMed, Radiother Oncol)

Tumor volume, p16, and CSC markers are potential biomarkers for HDF for patients with HNSCC treated with (C-)RT. Lower expression of CSC in p16+ OPSCC may contribute to better tumor control.

2 months ago

Journal • Cancer stem

CD44 (CD44 Molecule) • SLC3A2 (Solute Carrier Family 3 Member 2)

CDKN2A negative • CD44 expression

Nimoral (nimorazole)

2ms

Inhibition of RhoGEF/RhoA alleviates regorafenib resistance and cancer stemness via Hippo signaling pathway in hepatocellular carcinoma. (PubMed, Exp Cell Res)

LARG, RhoA, YAP1 and CD44 show positive correlation with each other. Thus, inhibition of RhoGEF/RhoA has the potential to reverse RR and repress CSC phenotype in HCC.

2 months ago

Journal

YAP1 (Yes associated protein 1) • CD44 (CD44 Molecule) • RHOA (Ras homolog family member A)

CD44 expression • RHOA mutation

Stivarga (regorafenib)

3ms

Distribution and Clinicopathological Features of Mott Cells (Plasma Cells Containing Russell Bodies) in Gastric Cancer: Presence of Mott Cells Is Associated with Favorable Prognosis. (PubMed, J Clin Med)

Additionally, the presence of Mott cells was associated with good prognosis in advanced GC and was an independent favorable prognostic predictor. The presence of Mott cells in GC might be one useful prognostic predictor, and Mott cells might have an important role in the carcinogenesis of H. pylori infection.

3 months ago

Journal

EGFR (Epidermal growth factor receptor) • CD44 (CD44 Molecule)

EGFR expression • CD44 expression