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    GENE:

    SPN (Sialophorin)

    i
    Other names: SPN, Sialophorin, GPL115, CD43, Leukosialin, LSN, Sialophorin (GpL115, Leukosialin, CD43), Leukocyte Sialoglycoprotein, Galactoglycoprotein, GALGP, CD43 Antigen
    23d
    Generation of TCRγδ + T cells from human embryonic stem cells. (PubMed, Sci Rep)
    RNA sequencing analysis revealed that the differentiation process of hESC-derived γδT cells was transcriptomically similar to those of in vivo courses. Therefore, our findings ultimately offer a novel technique to address the challenge of sourcing γδT cells for ACT therapies.
    Journal
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    CD34 (CD34 molecule) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • CD31 (Platelet and endothelial cell adhesion molecule 1) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • SPN (Sialophorin)
    2ms
    Myeloid sarcoma of the skull base: a brief review of the literature and a rare case confused radiologically with end plaque meningioma. (PubMed, Neurol Sci)
    This case underscores the diagnostic challenge of skull-base MS due to radiological mimicry and highlights an unusual brachial plexus extension, broadening its clinical spectrum. biopsy, prompt systemic therapy, and multidisciplinary management are essential, particularly in the presence of a very high Ki-67.
    Review • Journal
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    KIT (KIT proto-oncogene, receptor tyrosine kinase) • CD33 (CD33 Molecule) • CD34 (CD34 molecule) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • CD68 (CD68 Molecule) • SPN (Sialophorin)
    3ms
    Vaginal Myeloid Sarcoma: A Rare Extramedullary Presentation of a Myeloid Neoplasm. (PubMed, Cureus)
    The patient was treated with 16 cycles of chemotherapy and underwent allogeneic bone marrow transplantation. This case illustrates the diagnostic challenge of vaginal myeloid sarcoma and emphasizes the role of imaging, immunohistochemistry, and multidisciplinary management in such rare presentations.
    Journal
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    BCL2 (B-cell CLL/lymphoma 2) • CD38 (CD38 Molecule) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • CD7 (CD7 Molecule) • SPN (Sialophorin)
    4ms
    Peripheral blood plasmablasts, a potential confounder in chronic lymphocytic leukemia measureable residual disease analysis. (PubMed, Cytometry B Clin Cytom)
    Clinical implementation of the CLL assay revealed 12 out of 77 (16%) CLL PB patient samples demonstrating a small population of plasmablasts. Plasmablasts normally exist in peripheral blood at levels detectable by flow cytometry MRD assays and may be a potential confounder in the identification of MRD in CLL.
    Journal • IO biomarker
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    CD20 (Membrane Spanning 4-Domains A1) • CD38 (CD38 Molecule) • CD79B (CD79b Molecule) • ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • CD5 (CD5 Molecule) • CD200 (CD200 Molecule) • SPN (Sialophorin) • CD81 (CD81 Molecule) • FCER2 (Fc Fragment Of IgE Receptor II)
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    CD20 positive • PTPRC expression
    4ms
    IL-7 promotes the formation of DNA double strand breaks and DNA repair in murine pro-B cells. (PubMed, Front Immunol)
    It is well established that IL-7 promotes the proliferation and survival of acute lymphoblastic leukemia (ALL) cells. Our data suggest that drugs targeting IL-7 could improve ALL therapeutic protocols.
    Preclinical • Journal
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    IGH (Immunoglobulin Heavy Locus) • IL7 (Interleukin 7) • SPN (Sialophorin) • H2AX (H2A.X Variant Histone) • RAG1 (Recombination Activating 1)
    5ms
    Evaluation of the cytomorphology, immunophenotype, and molecular genetics of lymphoblastic lymphoma/leukemia in serous effusion. (PubMed, Acta Cytol)
    The integration of clinical manifestations, cytological evaluation, and gene expression profiles is instrumental in achieving accurate diagnosis, sub-classification, and prognosis of LBL/ALL within the context of SE.
    Journal
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    CD20 (Membrane Spanning 4-Domains A1) • ARID1A (AT-rich interaction domain 1A) • NOTCH1 (Notch 1) • NF1 (Neurofibromin 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • WT1 (WT1 Transcription Factor) • BCOR (BCL6 Corepressor) • PAX5 (Paired Box 5) • SETD2 (SET Domain Containing 2, Histone Lysine Methyltransferase) • CEBPA (CCAAT Enhancer Binding Protein Alpha) • JAK3 (Janus Kinase 3) • ARID2 (AT-Rich Interaction Domain 2) • CD5 (CD5 Molecule) • CD79A (CD79a Molecule) • MME (Membrane Metalloendopeptidase) • CD7 (CD7 Molecule) • CD2 (CD2 Molecule) • CD99 (CD99 Molecule) • SPN (Sialophorin) • MLLT10 (MLLT10 Histone Lysine Methyltransferase DOT1L Cofactor)
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    ARID1A mutation
    5ms
    CD169+ macrophages identify and eliminate tumor cells in colorectal cancer through CD169/CD43 interaction and FasL-driven apoptosis. (PubMed, Cell Rep)
    This interaction, mediated by CD169/CD43 molecular engagements, leads to tumor cell apoptosis via high levels of factor-related apoptosis ligand (FasL). Our results not only deepen our understanding of the CRC tumor microenvironment but also open avenues for cancer immunotherapy targeting.
    Journal
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    FASLG (Fas ligand) • SPN (Sialophorin)
    5ms
    Surfaceome CRISPR activation screening uncovers ligands regulating tumor sensitivity to NK cell killing. (PubMed, bioRxiv)
    Furthermore, we find that targeting CD43 on either NK cells or engineered T cells substantially enhances their cytotoxic activity against leukemia cell lines. These results establish gain-of-function screening as a powerful approach for discovering immunoregulatory surface proteins and identify multiple promising targets for enhancing NK cell-based cancer immunotherapies.
    Journal • IO biomarker
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    SPN (Sialophorin)
    6ms
    Subcutaneous Leukemia Cutis as the Initial Manifestation of CD23 Negative CLL/SLL in a Patient With Rheumatoid Arthritis on Chronic TNF-Alpha Inhibition. (PubMed, Case Rep Hematol)
    While treatments for CLL/SLL-induced leukemia cutis vary, in this case, consolidative local radiation led to resolution of the remaining cutaneous lesion. Caution is advised when considering the use of TNF-alpha inhibitors in patients with a history of lymphoma.
    Journal • IO biomarker
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    CD20 (Membrane Spanning 4-Domains A1) • CCND1 (Cyclin D1) • CD38 (CD38 Molecule) • CD5 (CD5 Molecule) • CD200 (CD200 Molecule) • SOX11 (SRY-Box Transcription Factor 11) • SPN (Sialophorin) • FCER2 (Fc Fragment Of IgE Receptor II)
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    CD20 positive
    6ms
    Immunophenotypic, cytogenetic, and mutational features of chronic lymphocytic leukemia/small lymphocytic lymphoma with atypical immunophenotype. (PubMed, Cytometry B Clin Cytom)
    In summary, approximately 20% of CLL cases show an atypical immunophenotype, and these cases have cytogenetic abnormalities and mutation profiles that differ in frequency from typical CLL cases. Recognition of the immunophenotype of atypical CLL can be helpful in the diagnosis and differential diagnosis in low-grade B-cell neoplasms.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • NRAS (Neuroblastoma RAS viral oncogene homolog) • CD20 (Membrane Spanning 4-Domains A1) • IGH (Immunoglobulin Heavy Locus) • KMT2D (Lysine Methyltransferase 2D) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1) • BIRC3 (Baculoviral IAP repeat containing 3) • CD22 (CD22 Molecule) • CD5 (CD5 Molecule) • CD200 (CD200 Molecule) • SPN (Sialophorin) • FCER2 (Fc Fragment Of IgE Receptor II)
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    KRAS mutation
    7ms
    Management Challenges of a Rare Case of a High-Grade T-Cell Lymphoma of the Vulva in a Premenopausal HIV-Infected Woman: A Case Report. (PubMed, Clin Case Rep)
    The patient was managed with combination chemotherapy Cyclophosphamide, Doxorubicin, Etoposide, Vincristine, and Prednisolone (CHOEP) protocol alongside continued antiretroviral therapy. She showed a favorable initial response with significant tumor regression and remains under close follow-up.
    Journal
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    BCL2 (B-cell CLL/lymphoma 2) • CD20 (Membrane Spanning 4-Domains A1) • PAX5 (Paired Box 5) • CD4 (CD4 Molecule) • NCAM1 (Neural cell adhesion molecule 1) • CD5 (CD5 Molecule) • CD2 (CD2 Molecule) • SPN (Sialophorin) • B3GAT1 (Beta-1,3-Glucuronyltransferase 1)
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    doxorubicin hydrochloride • cyclophosphamide • etoposide IV • vincristine
    7ms
    Structure-guided phage display discovery of antibodies for (S)Tn-glycans in protein context. (PubMed, Nat Chem Biol)
    Furthermore, internalization studies using the parental antibody scaffold show efficient uptake by tumor cells, supporting its use in antibody-drug conjugates. This platform addresses the challenge of generating glycoform-specific antibodies for cancer therapy.
    Journal
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    MUC1 (Mucin 1) • SPN (Sialophorin)