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GENE:

CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex)

News alerts, weekly reports and conference planners

SHEST: single-cell-level artificial intelligence from haematoxylin and eosin morphology for cell-type prediction and spatial transcriptomics reconstruction. (PubMed, Brief Bioinform)

By unifying cell-type identification, gene expression reconstruction, and spatial mapping within a single interpretable framework, SHEST provides a synergistic and cost-efficient bridge between histopathology and spatial transcriptomics. This approach facilitates comprehensive tissue characterization and forms a foundation for precision oncology through spatially informed, cell-level insights into tumour-immune ecosystems.

6 days ago

Journal

EPCAM (Epithelial cell adhesion molecule) • CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex)

19d

Main Genes Linked to the Immune Microenvironment in High-Grade Serous Ovarian Cancer. (PubMed, Adv Biomed Res)

The current study recognized the most relevant genes involved in the immune system in high-grade serous ovarian cancer. The findings of this study provided a holistic understanding of the tumor microenvironment that can be used for introducing therapeutic targets.

19 days ago

Journal • IO biomarker

IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) • FANCD2 (FA Complementation Group D2) • PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22) • STAT4 (Signal Transducer And Activator Of Transcription 4) • CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex)

3ms

Development of DARPin T cell engagers for specific targeting of tumor-associated HLA/peptide complexes. (PubMed, iScience)

A cryo-EM structure of the ternary DARPin/HLA-A∗0201/NY-ESO1157-165 complex revealed a rigid, concave DARPin surface spanning the full length of the peptide-binding cleft, contacting both α-helices and the peptide. The present findings reveal promising immuno-oncotherapeutic approaches and demonstrate the feasibility of rapidly developing DARPins with high affinity and specificity for HLA/peptide targets, which can be readily combined with a new generation of anti-CD3e-specific DARPins.

3 months ago

Journal

CD8 (cluster of differentiation 8) • CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex)

3ms

Multiplex gene-editing strategy to engineer allogeneic EGFR-targeting CAR T-cells with improved efficacy against solid tumors. (PubMed, Nat Commun)

This combinatorial genetic disruption enhances CAR T cell effector function and anti-tumor efficacy leading to improved tumor elimination and survival in xenograft and humanized mouse solid tumor models. Our strategy confers CAR T cells resistance to multiple clinically relevant inhibitory signaling pathways that are amplified in hypoxic tumor areas and may improve the therapeutic potential of CAR T-cells against solid tumors.

3 months ago

Journal

PD-1 (Programmed cell death 1) • B2M (Beta-2-microglobulin) • TGFBR2 (Transforming Growth Factor Beta Receptor 2) • TGFB1 (Transforming Growth Factor Beta 1) • ADORA2A (Adenosine A2a Receptor) • CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex)

4ms

Diverse PD-1, CD163, and FOXP3 Profiles in Primary and Metastatic Microenvironments of Prostate Cancer. (PubMed, Oncol Res)

Diverse PD-1, CD163, and FOXP3 profiles were observed in primary and metastatic microenvironments of prostate cancer. These findings may contribute to the development of personalized therapeutic strategies and novel prognostic tools beyond conventional histological and TNM staging.

4 months ago

Journal • PD(L)-1 Biomarker • IO biomarker

CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • CD276 (CD276 Molecule) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • CD163 (CD163 Molecule) • CD68 (CD68 Molecule) • FOXP3 (Forkhead Box P3) • MKI67 (Marker of proliferation Ki-67) • CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex)

4ms

Intraepithelial Lymphocytes and LAIR1 Expression in Celiac Disease. (PubMed, Biomedicines)

IELs exhibit a cytotoxic T-cell phenotype and were found to be CD3+, CD8+, CD103+, TCR beta+, and LAIR1+ in the small intestine control. Increased numbers of LAIR1+ IELs and lamina propria immune cells characterize CD.

4 months ago

Journal • PD(L)-1 Biomarker • IO biomarker

PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • CD163 (CD163 Molecule) • CD4 (CD4 Molecule) • NCAM1 (Neural cell adhesion molecule 1) • TNFRSF14 (TNF Receptor Superfamily Member 14) • GZMB (Granzyme B) • BTLA (B And T Lymphocyte Associated) • FCGR3A (Fc Fragment Of IgG Receptor IIIa) • FOXP3 (Forkhead Box P3) • ITGAE (Integrin Subunit Alpha E) • IL4I1 (Interleukin 4 Induced 1) • LAIR1 (Leukocyte Associated Immunoglobulin Like Receptor 1) • CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex)

4ms

Subtype-specific genetic drivers of immune evasion in breast cancer. (PubMed, Immunooncol Technol)

In HER2-positive BC, a three-gene signature (IL2RG, CD3E, CD3G) was consistently prognostic (HR 0.41, 95% CI 0.24-0.71, P = 0.0011, GEO) across independent datasets. We identified subtype-specific signatures that predict survival and immunotherapy response, providing clinically actionable biomarkers.

4 months ago

Journal • IO biomarker

HER-2 (Human epidermal growth factor receptor 2) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • CXCL9 (Chemokine (C-X-C motif) ligand 9) • JAK3 (Janus Kinase 3) • CD3G (CD3 Gamma Subunit Of T-Cell Receptor Complex) • CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex) • IL2RG (Interleukin 2 Receptor Subunit Gamma)

HER-2 positive • EGFR positive

5ms

Identification and non-clinical characterization of SAR444200, a novel anti-GPC3 NANOBODY® T-cell engager, for the treatment of GPC3+ solid tumors. (PubMed, Mol Cancer Ther)

The highly potent and efficacious activity of SAR444200 in diverse models of GPC3+ tumors and the extremely wide tolerated dose range merits further development of this compound. Furthermore, NANOBODY®-based TCEs developed using an anti-TCRαβ moiety may have specific advantages for the development of TCEs.

5 months ago

Journal • IO biomarker

GPC3 (Glypican 3) • CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex)

SAR444200

5ms

DNA methylation mediates the immunosuppressive tumour microenvironment in metastatic endometrial clear cell carcinoma. (PubMed, EBioMedicine)

This study illuminated the "epigenetic-immune axis" as a central regulatory mechanism driving ECCC metastasis. DNA methylation systematically silenced immune response genes by targeting ETS1-binding sites and TCR signalling components, thus reconstructing the immunosuppressive TME to facilitate metastasis. The development of the metastatic risk score model and identification of LCK as a potential therapeutic target provide valuable strategies for precision treatment decisions and advancing targeted epigenetic-immune therapies in ECCC.

5 months ago

Journal • IO biomarker

ETS1 (ETS Proto-Oncogene 1) • LCK (LCK Proto-Oncogene, Src Family Tyrosine Kinase) • CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex)

5ms

Olfactory receptors as tumor suppressors in cutaneous T-cell lymphoma via p38γ pathway modulation. (PubMed, Blood Neoplasia)

Membranous OR4N5 no longer interacts with CD3E in CTCL cells, which sets TCR signaling transduction on the loose via depending on other mechanisms such as the DLGH1-p38γ-nuclear factor of activated T-cells 1 axis. Analysis of public data sets shows that most ORs are significantly downregulated in cancer, suggesting their grassroot tumor suppressors role when a network emerged as they teamed together against cancer.

5 months ago

Journal • IO biomarker

NFATC1 (Nuclear Factor Of Activated T Cells 1) • CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex)

6ms

Prognostic Implications of T Cell Receptor Repertoire Diversity in Cervical Lymph Nodes of Oral Squamous Cell Carcinoma Patients. (PubMed, Int J Mol Sci)

The immune profiling of LNs offers superior prognostic value over tumor analysis in OSCC patients with LN metastasis. LN-based evaluation may aid in postoperative risk stratification and personalized postoperative management and could inform decisions regarding adjuvant therapy and follow-up strategies.

6 months ago

Journal • IO biomarker

CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • CD4 (CD4 Molecule) • IL2 (Interleukin 2) • FOXP3 (Forkhead Box P3) • GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) • IL4 (Interleukin 4) • CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex)

7ms

IFNγ Expression Correlates with Enhanced Cytotoxicity in CD8+ T Cells. (PubMed, Int J Mol Sci)

Our findings establish a link between elevated IFNγ production and enhanced CTL cytotoxicity, implicating CRTAM as a potential regulator of early CTL activation and IFNγ induction. These insights provide a foundation for optimizing T cell-based immunotherapies against infections and cancers.

7 months ago

Journal • IO biomarker

CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • LAMP1 (Lysosomal Associated Membrane Protein 1) • GZMB (Granzyme B) • CRTAM (Cytotoxic And Regulatory T Cell Molecule) • CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex)