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4ms
A dual-targeting approach with anti-IL10R CAR-T cells engineered to release anti-CD33 bispecific antibody in enhancing killing effect on acute myeloid leukemia cells. (PubMed, Cell Oncol (Dordr))
Overall, the engineering of a single-vector targeting IL10R CAR, which subsequently secretes CD33-targeted bsAb, addresses the issue of immune escape due to the heterogeneous expression of IL10R and CD33, and represents a promising progress in AML therapy aimed at improving treatment outcomes.
Journal • CAR T-Cell Therapy • IO biomarker
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IL10 (Interleukin 10)
|
CD33 CAR-T
10ms
Myeloid leukemia-derived galectin-1 downregulates CAR expression to hinder cytotoxicity of CAR T cells. (PubMed, J Transl Med)
The discovery of the role of galectin-1 in cell surface CAR down-regulation provides important insights for developing strategies to restore anti-tumor functions.
Journal • CAR T-Cell Therapy
|
CD33 (CD33 Molecule) • LGALS1 (Galectin 1)
|
CD33 CAR-T
almost2years
Off-the-Shelf, Multiplexed-Engineered iPSC-Derived CD33 CAR-NK Cells for Treatment of Acute Myeloid Leukemia (ASH 2022)
Immune cell therapy has become a cornerstone in cancer therapy. When administered in combination with daratumumab, QN-023a demonstrated superior ADCC compared to unmodified iPSC-derived NK cells against primary AML blasts from patients. Together, we have engineered iPSC-derived QN-023a NK cells as promising clinical drug candidates for treatment of AML.
IO biomarker
|
CD33 (CD33 Molecule) • IL15 (Interleukin 15) • NKG2D (killer cell lectin like receptor K1)
|
Darzalex (daratumumab) • CD33 CAR-T • QN-023a
over2years
New P1 trial
|
CD33 (CD33 Molecule)
|
CD33 positive
|
CD33 CAR-T
over2years
New P1 trial
|
CD33 (CD33 Molecule)
|
CD33 positive
|
CD33 CAR-T • CLL1+CD33 CAR-T