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    BIOMARKER:

    CD28 overexpression

    i
    Other names: CD28, CD28 Molecule, T-Cell-Specific Surface Glycoprotein CD28, CD28 Antigen, T-Cell-Specific Surface Glycoprotein, CD28 Antigen (Tp44), Tp44, TP44
    Entrez ID:
    940
    Related biomarkers:
    Expression
    Others
    4ms
    Low blood level of tumour suppressor miR-5193 as a target of immunotherapy to PD-L1 in gastric cancer. (PubMed, Br J Cancer)
    Low blood levels of miR-5193 are associated with GC progression and poor outcomes and could be a target of nucleic acid immunotherapy in GC patients.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    IFNG (Interferon, gamma) • CD28 (CD28 Molecule) • MIR520H (MicroRNA 520h)
    |
    PD-L1 expression • CD28 overexpression • CD28 expression
    over2years
    Clinicopathological significance of CD28 overexpression in adult T-cell leukemia/lymphoma. (PubMed, Cancer Sci)
    The same was true for a subgroup who were treated with multidrug regimens with or without mogamulizumab...These results suggest ATLL patients with CD28 overexpression have more aggressive clinical course and are more refractory to treatment with multidrug chemotherapy. CD28 overexpression appear to be a novel unfavorable prognostic marker in ATLL patients, and further prospective studies are warranted to establish its prognostic significance.
    Clinical • Journal
    |
    CD28 (CD28 Molecule) • CD86 (CD86 Molecule)
    |
    CD28 overexpression • CD2 overexpression
    |
    Poteligeo (mogamulizumab-kpkc)