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    DRUG CLASS:

    CD22-targeted CAR-T immunotherapy

    Related drugs:
    17h
    Multi-4SCAR-T Therapy Targeting Breast Cancer (clinicaltrials.gov)
    P1/2, N=100, Recruiting, Shenzhen Geno-Immune Medical Institute | Trial completion date: Dec 2023 --> Dec 2030 | Trial primary completion date: May 2023 --> Dec 2029
    Trial completion date • Trial primary completion date
    |
    HER-2 (Human epidermal growth factor receptor 2)
    |
    HER-2 expression
    |
    4SCAR-T
    20h
    CD19/22 Bi-specific CAR-T Cell Therapy (clinicaltrials.gov)
    P1/2, N=60, Recruiting, Shenzhen Geno-Immune Medical Institute | Trial completion date: Jun 2026 --> Dec 2030 | Trial primary completion date: Dec 2025 --> Dec 2029
    Trial completion date • Trial primary completion date
    |
    CD19 (CD19 Molecule) • CD22 (CD22 Molecule)
    5d
    Differential cytokine architecture in patients treated with CART19 versus CART22. (PubMed, J Immunother Cancer)
    These findings reveal IL-10 as a potent CRS-mitigating factor and support IL-10 enhancement strategies to improve the safety of CART.
    Journal
    |
    IFNG (Interferon, gamma) • IL6 (Interleukin 6) • CD22 (CD22 Molecule) • CD4 (CD4 Molecule) • IL10 (Interleukin 10) • SOCS3 (Suppressor Of Cytokine Signaling 3)
    |
    CART22
    6d
    4SCAR-T Therapy Targeting GD2, PSMA and CD276 for Treating Neuroblastoma (clinicaltrials.gov)
    P1/2, N=100, Recruiting, Shenzhen Geno-Immune Medical Institute | Trial completion date: Dec 2023 --> Dec 2030 | Trial primary completion date: Nov 2020 --> Dec 2029
    Trial completion date • Trial primary completion date
    |
    CD276 (CD276 Molecule)
    |
    4SCAR-T • GD2, PSMA and CD276 CAR-T
    6d
    Multi-CAR-T Cells Targeting B Cell Lymphomas (clinicaltrials.gov)
    P1/2, N=11, Recruiting, Shenzhen Geno-Immune Medical Institute | Trial completion date: Dec 2023 --> Dec 2030 | Trial primary completion date: Jul 2023 --> Dec 2029
    Trial completion date • Trial primary completion date
    |
    CD19 (CD19 Molecule) • CD79B (CD79b Molecule) • CD22 (CD22 Molecule) • CD70 (CD70 Molecule) • ANPEP (Alanyl Aminopeptidase, Membrane)
    |
    multi-CAR-T cell therapy
    6d
    4SCAR-T Therapy Post CD19-targeted Immunotherapy (clinicaltrials.gov)
    P1/2, N=100, Recruiting, Shenzhen Geno-Immune Medical Institute | Trial completion date: Dec 2023 --> Dec 2030 | Trial primary completion date: May 2023 --> Dec 2029
    Trial completion date • Trial primary completion date
    |
    CD20 (Membrane Spanning 4-Domains A1) • CD38 (CD38 Molecule) • CD123 (Interleukin 3 Receptor Subunit Alpha) • CD22 (CD22 Molecule) • MME (Membrane Metalloendopeptidase) • IL3RA (Interleukin 3 Receptor Subunit Alpha)
    |
    4SCAR-T
    16d
    PLAT-04: A Phase 1 Study of CD22-CAR TCell Immunotherapy for CD22+ Leukemia and Lymphoma (clinicaltrials.gov)
    P1, N=4, Completed, Seattle Children's Hospital | Active, not recruiting --> Completed
    Trial completion
    |
    CD22 (CD22 Molecule)
    20d
    Human CD19-CD22 Targeted T Cells Injection for Refractory/Relapsed Central Nervous System Leukemia/Lymphoma Patients (clinicaltrials.gov)
    P1, N=10, Active, not recruiting, Hrain Biotechnology Co., Ltd. | Recruiting --> Active, not recruiting | Trial completion date: Aug 2025 --> May 2027
    Enrollment closed • Trial completion date
    |
    CD22 (CD22 Molecule) • IL15 (Interleukin 15)
    |
    CD22 positive
    |
    anti-CD19/CD22 CAR-T cells
    21d
    CAR-T for R/R B-NHL (clinicaltrials.gov)
    P2, N=168, Completed, The First Affiliated Hospital of Soochow University | Unknown status --> Completed | N=10 --> 168
    Trial completion • Enrollment change
    |
    CD20 (Membrane Spanning 4-Domains A1) • TNFRSF8 (TNF Receptor Superfamily Member 8) • CD22 (CD22 Molecule)
    |
    CAR-T CD19/CD20/CD22/CD30
    25d
    Immunotherapy Combined With Auto-HSCT and CD22/CD19 CAR-T Sandwich Strategy for B-ALL (clinicaltrials.gov)
    P2, N=40, Suspended, The First Affiliated Hospital of Soochow University | Not yet recruiting --> Suspended
    Trial suspension
    |
    CD19 (CD19 Molecule) • CD22 (CD22 Molecule)
    |
    CD22/CD19 CAR T
    26d
    OSU-21170: Genetically Engineered Cells (Anti-CD19/CD20/CD22 CAR T-cells) for the Treatment of Relapsed or Refractory Lymphoid Malignancies (clinicaltrials.gov)
    P1, N=54, Recruiting, Sumithira Vasu | Trial primary completion date: Jul 2026 --> Jul 2027
    Trial primary completion date
    |
    CD20 (Membrane Spanning 4-Domains A1) • CD22 (CD22 Molecule)
    |
    cyclophosphamide • fludarabine IV • TriCAR19.20.22 T cells
    27d
    CD22/CD19 CAR-T and Auto-HSCT Sandwich Strategy as Consolidation Therapy for B-ALL (clinicaltrials.gov)
    P2, N=37, Active, not recruiting, The First Affiliated Hospital of Soochow University | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    CD19 (CD19 Molecule) • CD22 (CD22 Molecule)
    |
    CD22/CD19 CAR T