CD20 underexpression

High BID and low CD20 expression were associated with inferior overall survival, while high BID and low JAK3 and CD20 expression were linked to poorer progression-free survival. These findings highlight altered protein profiles in pretreatment cHL biopsies associated with BPT development.

Anemia, a common adverse effect in feline nasal lymphoma, did not impact MST. T1 clinical staging and high CD20 expression showed a trend for better MST.

Cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) treatment regimen has been used for the last decades. As a consequence, the expression of HDAC7 enhanced response to R-CHOP therapy in these cell lines compared to standard CHOP treatment, measured by an induction of apoptosis in DLBCL cells. DLBCL cell lines overexpressing HDAC7 or with high levels of HDAC7 showed an increase in apoptosis when treated with R-CHOP instead of CHOP alone.ConclusionOur data suggest that precise induction of HDAC7 in DLBCL induces CD20 expression, increasing sensitivity of resistant cells to R-CHOP therapy and potentially improving final outcome of DLBCL-diagnosed patients.

Background R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) is the standard of care for newly diagnosed and untreated diffuse large B-cell lymphoma (DLBCL); however, approximately 30–40% of patients relapse or become refractory...POLARIX (NCT03274492) evaluated a modified regimen substituting polatuzumab vedotin for vincristine (pola-R-CHP), showing a modest improvement in PFS without OS benefit between treatment arms, indicating an unmet clinical need remains...The sensitivity and specificity of minimal residual disease (MRD) for early detection of disease progression is an exploratory endpoint; further MRD parameters may also be investigated. The study is funded by MorphoSys AG and conducted with the scientific support of members of the Fondazione Italiana Linfomi and the German Lymphoma Alliance.

Moreover, CD20 expression might differ between blood (pb) and bone marrow (bm) and varies under prednisone during early treatment...Methods Comparative immunophenotypic quantification of CD20 expression in 207 B-ALL pts was performed at diagnosis (pb d0 and/or bm d0) and/or (a/o) after a 5-day dexamethasone- and cyclophosphamide-containing prephase (pb d6) under EuroFlow standardized procedures...Accordingly, R seems to improve the early MRD response predominantly in pts with higher CD20 expression. Supported by DJCLS