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    DRUG CLASS:

    CD20-targeted CAR-T immunotherapy

    Related drugs:
    3d
    A Study of LCAR-AIO CAR-T Cells for Treating Relapsed/Refractory Neurological Autoimmune Diseases (clinicaltrials.gov)
    P1, N=0, Withdrawn, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | N=37 --> 0 | Recruiting --> Withdrawn
    Enrollment change • Trial withdrawal
    |
    LCAR-AIO
    4d
    Multi-4SCAR-T Therapy Targeting Breast Cancer (clinicaltrials.gov)
    P1/2, N=100, Recruiting, Shenzhen Geno-Immune Medical Institute | Trial completion date: Dec 2023 --> Dec 2030 | Trial primary completion date: May 2023 --> Dec 2029
    Trial completion date • Trial primary completion date
    |
    HER-2 (Human epidermal growth factor receptor 2)
    |
    HER-2 expression
    |
    4SCAR-T
    9d
    4SCAR-T Therapy Targeting GD2, PSMA and CD276 for Treating Neuroblastoma (clinicaltrials.gov)
    P1/2, N=100, Recruiting, Shenzhen Geno-Immune Medical Institute | Trial completion date: Dec 2023 --> Dec 2030 | Trial primary completion date: Nov 2020 --> Dec 2029
    Trial completion date • Trial primary completion date
    |
    CD276 (CD276 Molecule)
    |
    4SCAR-T • GD2, PSMA and CD276 CAR-T
    9d
    Multi-CAR-T Cells Targeting B Cell Lymphomas (clinicaltrials.gov)
    P1/2, N=11, Recruiting, Shenzhen Geno-Immune Medical Institute | Trial completion date: Dec 2023 --> Dec 2030 | Trial primary completion date: Jul 2023 --> Dec 2029
    Trial completion date • Trial primary completion date
    |
    CD19 (CD19 Molecule) • CD79B (CD79b Molecule) • CD22 (CD22 Molecule) • CD70 (CD70 Molecule) • ANPEP (Alanyl Aminopeptidase, Membrane)
    |
    multi-CAR-T cell therapy
    9d
    4SCAR-T Therapy Post CD19-targeted Immunotherapy (clinicaltrials.gov)
    P1/2, N=100, Recruiting, Shenzhen Geno-Immune Medical Institute | Trial completion date: Dec 2023 --> Dec 2030 | Trial primary completion date: May 2023 --> Dec 2029
    Trial completion date • Trial primary completion date
    |
    CD20 (Membrane Spanning 4-Domains A1) • CD38 (CD38 Molecule) • CD123 (Interleukin 3 Receptor Subunit Alpha) • CD22 (CD22 Molecule) • MME (Membrane Metalloendopeptidase) • IL3RA (Interleukin 3 Receptor Subunit Alpha)
    |
    4SCAR-T
    16d
    M-2024-423: US Zamto-cel Autoimmune Diseases (clinicaltrials.gov)
    P1, N=48, Recruiting, Miltenyi Biomedicine GmbH | Not yet recruiting --> Recruiting | Trial completion date: Dec 2026 --> Jul 2028 | Trial primary completion date: Dec 2026 --> Jan 2028
    Enrollment open • Trial completion date • Trial primary completion date
    |
    cyclophosphamide • fludarabine IV • zamtocabtagene autoleucel (MB-CART2019.1)
    16d
    Long-term Study to Evaluate Safety and Persistence of GF-CART01 (clinicaltrials.gov)
    P=N/A, N=18, Enrolling by invitation, GenomeFrontier Therapeutics TW Co., Ltd. | Not yet recruiting --> Enrolling by invitation
    Enrollment open
    22d
    A Study of JNJ-90014496 in Participants With B-Cell Non-Hodgkin Lymphoma (clinicaltrials.gov)
    P1/2, N=439, Recruiting, Janssen Research & Development, LLC | Trial completion date: Mar 2029 --> Jul 2041
    Trial completion date
    |
    CD20 (Membrane Spanning 4-Domains A1)
    |
    CD20 positive
    |
    prizloncabtagene autoleucel (JNJ-4496)
    24d
    CAR-T for R/R B-NHL (clinicaltrials.gov)
    P2, N=168, Completed, The First Affiliated Hospital of Soochow University | Unknown status --> Completed | N=10 --> 168
    Trial completion • Enrollment change
    |
    CD20 (Membrane Spanning 4-Domains A1) • TNFRSF8 (TNF Receptor Superfamily Member 8) • CD22 (CD22 Molecule)
    |
    CAR-T CD19/CD20/CD22/CD30
    29d
    OSU-21170: Genetically Engineered Cells (Anti-CD19/CD20/CD22 CAR T-cells) for the Treatment of Relapsed or Refractory Lymphoid Malignancies (clinicaltrials.gov)
    P1, N=54, Recruiting, Sumithira Vasu | Trial primary completion date: Jul 2026 --> Jul 2027
    Trial primary completion date
    |
    CD20 (Membrane Spanning 4-Domains A1) • CD22 (CD22 Molecule)
    |
    cyclophosphamide • fludarabine IV • TriCAR19.20.22 T cells
    1m
    OSU-21170: Genetically Engineered Cells (Anti-CD19/CD20/CD22 CAR T-cells) for the Treatment of Relapsed or Refractory Lymphoid Malignancies (clinicaltrials.gov)
    P1, N=54, Recruiting, Sumithira Vasu | Trial completion date: Jul 2026 --> Jul 2027
    Trial completion date
    |
    CD20 (Membrane Spanning 4-Domains A1) • CD22 (CD22 Molecule)
    |
    cyclophosphamide • fludarabine IV • TriCAR19.20.22 T cells
    2ms
    Study Evaluating the Efficacy of KITE-753 Versus Axicabtagene Ciloleucel in Participants With Relapsed or Refractory Large B-Cell Lymphoma After First-Line Therapy (clinicaltrials.gov)
    P3, N=550, Recruiting, Kite, A Gilead Company | Not yet recruiting --> Recruiting
    Enrollment open
    |
    cyclophosphamide • Yescarta (axicabtagene ciloleucel) • fludarabine IV