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    GENE:

    CD2 (CD2 Molecule)

    i
    Other names: CD2, CD2 Molecule, CD2 Antigen (P50), Sheep Red Blood Cell Receptor, T-Cell Surface Antigen T11/Leu-5, T-Cell Surface Antigen CD2, Erythrocyte Receptor, Rosette Receptor, LFA-3 Receptor, LFA-2, SRBC, Lymphocyte-Function Antigen-2, CD2 Antigen, T11
    9d
    The Elusive Diagnosis: A Case of Extranodal Natural Killer (NK)/T-Cell Lymphoma. (PubMed, Cureus)
    Standard treatment includes combined chemotherapy and radiotherapy, yet the prognosis remains poor. This report aims to raise awareness of this entity and emphasize the importance of considering it in atypical or treatment-refractory cases of orbital cellulitis, bacterial sinusitis, and other inflammatory conditions.
    Journal
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    NCAM1 (Neural cell adhesion molecule 1) • CD2 (CD2 Molecule)
    10d
    Analysis of ten cases of Acute lymphoblastic leukemia with non-KMT2A::AFF1 transcriptional variant 11q23 rearrangements (PubMed, Zhonghua Yi Xue Yi Chuan Xue Za Zhi)
    The 11q23 rearrangement ALL with non-KMT2A::AFF1 transcript is mainly KMT2A::MLLT1, T-ALL is more common, and the rate of chromosomal karyotype detection is relatively low. Persistent positive KMT2A-r is unfavorable for patient survival, and allo-HSCT during the CR1 period may improve patient survival.
    Retrospective data • Journal • IO biomarker
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    CD20 (Membrane Spanning 4-Domains A1) • CD19 (CD19 Molecule) • CD8 (cluster of differentiation 8) • KMT2A (Lysine Methyltransferase 2A) • CD38 (CD38 Molecule) • WT1 (WT1 Transcription Factor) • CD22 (CD22 Molecule) • AFF1 (AF4/FMR2 Family Member 1) • CD34 (CD34 molecule) • CD5 (CD5 Molecule) • MME (Membrane Metalloendopeptidase) • CD7 (CD7 Molecule) • MLLT3 (MLLT3 Super Elongation Complex Subunit) • CD2 (CD2 Molecule) • AFDN (Afadin, Adherens Junction Formation Factor) • FUT4 (Fucosyltransferase 4) • MLLT10 (MLLT10 Histone Lysine Methyltransferase DOT1L Cofactor)
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    KMT2A rearrangement
    10d
    Nebivolol prevents exhausted T cells and enhances cytotoxicity against MCF-7 breast cancer cells in a β2-adrenergic receptor-dependent manner. (PubMed, Clin Exp Immunol)
    These findings show that nebivolol reinvigorates CD4+ and CD8+ T cells following repeated activation, restoring their cytotoxic function against breast cancer cells in vitro. The immunomodulatory activity of Nebivolol is independent of β1-AR and mediated through β2-AR, suggesting that biased β₂-AR signaling may represent a potential strategy for modulating T cell exhaustion in the tumor microenvironment.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • CD38 (CD38 Molecule) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • CD4 (CD4 Molecule) • ADRB2 (Adrenoceptor Beta 2) • CD2 (CD2 Molecule) • NFATC1 (Nuclear Factor Of Activated T Cells 1)
    17d
    A challenging case of facial oedemas revealing a systemic peripheral T-cell lymphoma, not otherwise specified. (PubMed, Eur J Dermatol)
    In our case, as extracutaneous disease was present from the beginning, the diagnosis would be better classified as systemic (non-primary cutaneous) PTCL-NOS. This report emphasizes the importance of repeated biopsies and expert reviews for diagnosing and managing PTCL, which can have a highly variable and poor prognosis.
    Journal
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    CD8 (cluster of differentiation 8) • CD5 (CD5 Molecule) • GZMB (Granzyme B) • CD7 (CD7 Molecule) • CD2 (CD2 Molecule) • PRF1 (Perforin 1)
    22d
    Small particles of Echinococcus granulosus (spegs) and Echinococcus multilocularis (spems) promote follicular T helper cell expansion and are associated with IgE and IgG4 class switching in human lymph nodes. (PubMed, Parasit Vectors)
    Spegs and spems are associated with changes in the host immune response, characterized by an increased accumulation of Tfh in germinal centers. This finding is accompanied by the presence of IgE and IgG4 plasma cells in the lymph node and the perilesional area, suggesting parasite-associated immunomodulatory processes in echinococcosis.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • CD4 (CD4 Molecule) • GZMB (Granzyme B) • CD2 (CD2 Molecule) • B3GAT1 (Beta-1,3-Glucuronyltransferase 1) • SPEG (Striated Muscle Enriched Protein Kinase)
    1m
    Extranodal NK/T-Cell Lymphoma, Nasal Type, Presenting as an Isolated Oral Manifestation. (PubMed, Dent J (Basel))
    Persistent, progressive, or therapy-resistant oral ulcerations should prompt early consideration of hematologic malignancy. Timely biopsy with comprehensive immunophenotyping, EBV testing, and close multidisciplinary collaboration are essential for accurate diagnosis and may contribute to earlier diagnosis and improved patient outcomes in these rare and atypical presentations.
    Journal • IO biomarker
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    TNFRSF8 (TNF Receptor Superfamily Member 8) • NCAM1 (Neural cell adhesion molecule 1) • CD5 (CD5 Molecule) • CD7 (CD7 Molecule) • CD2 (CD2 Molecule) • TRG (T Cell Receptor Gamma Locus)
    2ms
    CCR4 expression defines a targetable subset of T-cell acute lymphoblastic leukemia. (PubMed, Blood Adv)
    We analyzed the T-ALL microenvironment from 40 T-ALL cases treated on the AALL0434 clinical trial and identified a subpopulation of bone-marrow-enriched CCR4+ FOXP3+ T-regulatory cells which express immune checkpoints (PD-1 and TIGIT) and could be targeted with anti-CCR4 therapy. Lastly, we describe the preclinical efficacy of an anti-CCR4 CAR-T in in vitro and in vivo models, paving the way for future translational efforts in chemotherapy refractory T-ALL.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    CD38 (CD38 Molecule) • CCR4 (C-C Motif Chemokine Receptor 4) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • CD5 (CD5 Molecule) • CD7 (CD7 Molecule) • FOXP3 (Forkhead Box P3) • CD2 (CD2 Molecule)
    2ms
    Rapid receptor internalization potentiates CD7-targeted lipid nanoparticles for efficient mRNA delivery to T cells and in vivo CAR T-cell engineering. (PubMed, bioRxiv)
    These findings provide a rational framework for selecting optimal targeting moiety to enable highly efficient in vivo CAR T-cell engineering. Targeting CD7 outperforms other receptors for tLNP-mRNA delivery to T cellsReceptor abundance does not predict tLNP-mRNA delivery efficiencyReceptor internalization kinetics governs tLNP-mRNA delivery efficiency CD7-targeting LNP-mRNA enables efficient in vivo CAR T-cell engineering.
    Preclinical • Journal
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    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • CD5 (CD5 Molecule) • CD7 (CD7 Molecule) • CD2 (CD2 Molecule)
    2ms
    Association between leukemic immunophenotype and overall survival in patients with acute promyelocytic leukemia: a retrospective cohort study. (PubMed, Front Cell Dev Biol)
    Compared with non-APL-AML patients, APL patients (PML-RARα (S-type) and PML-RARα (L-type)) exhibit unique immunophenotypic changes. The expression frequencies of CD56, CD2, CD34, and CD200 in leukemia cells are significantly correlated with the OS of APL patients, and the high expression of these indicators before treatment may be an adverse prognostic factor for APL patients.
    Retrospective data • Journal • IO biomarker
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    CD38 (CD38 Molecule) • RARA (Retinoic Acid Receptor Alpha) • CD33 (CD33 Molecule) • PML (Promyelocytic Leukemia) • CD34 (CD34 molecule) • NCAM1 (Neural cell adhesion molecule 1) • CD200 (CD200 Molecule) • CD9 (CD9 Molecule) • CD7 (CD7 Molecule) • CD2 (CD2 Molecule) • ANPEP (Alanyl Aminopeptidase, Membrane)
    3ms
    CD2 costimulation bridges potent CAR-induced cytolysis and durable persistence. (PubMed, J Immunother Cancer)
    The CD2 cytoplasmic tail, in combination with CD3z, delivers balanced costimulation that couples brisk tumor debulking to T cell persistence. CD2z therefore may provide a simple, versatile alternative to canonical CD28 and 4-1BB modules for next-generation CAR T therapies.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • CD58 (CD58 Molecule) • CD2 (CD2 Molecule)
    3ms
    In Situ Enzymatic Generation of Metal-Organic Frameworks for Target-Gated Electrochemiluminescence Detection of miRNA. (PubMed, Anal Chem)
    Since urease was introduced onto the electrode in the presence of target miRNAs, this target-gated ECL sensing strategy was established with a wide linear detection range from 1.0 fM to 1.0 nM for the thyroid cancer marker miRNA-146b-5p, and a detection limit as low as 0.59 fM, along with concise operation and rapid response. The target-gated generation of MOF emitters not only achieved unprecedented specificity and exceptional signal-to-noise ratio, but also expanded the applications of MOF-based ECL in biosensing.
    Journal
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    CD2 (CD2 Molecule)
    3ms
    An Unforeseen Diagnosis After Liver Transplantation for Acute Liver Failure: Extranodal NK/T-Cell Lymphoma. (PubMed, Case Reports Hepatol)
    Although horsetail tea is associated with liver injury, its contribution to ALF remains insufficiently defined, reinforcing the importance of excluding alternative causes. ENKTL and other malignancies should be considered in indeterminate ALF, even without imaging findings, atypical lymphocytes in peripheral blood/ascites, or overt clinical suspicion of malignancy.
    Journal
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    CD8 (cluster of differentiation 8) • NCAM1 (Neural cell adhesion molecule 1) • CD2 (CD2 Molecule)