CD2 (CD2 Molecule)

We analyzed the T-ALL microenvironment from 40 T-ALL cases treated on the AALL0434 clinical trial and identified a subpopulation of bone-marrow-enriched CCR4+ FOXP3+ T-regulatory cells which express immune checkpoints (PD-1 and TIGIT) and could be targeted with anti-CCR4 therapy. Lastly, we describe the preclinical efficacy of an anti-CCR4 CAR-T in in vitro and in vivo models, paving the way for future translational efforts in chemotherapy refractory T-ALL.

These findings provide a rational framework for selecting optimal targeting moiety to enable highly efficient in vivo CAR T-cell engineering. Targeting CD7 outperforms other receptors for tLNP-mRNA delivery to T cellsReceptor abundance does not predict tLNP-mRNA delivery efficiencyReceptor internalization kinetics governs tLNP-mRNA delivery efficiency CD7-targeting LNP-mRNA enables efficient in vivo CAR T-cell engineering.

Compared with non-APL-AML patients, APL patients (PML-RARα (S-type) and PML-RARα (L-type)) exhibit unique immunophenotypic changes. The expression frequencies of CD56, CD2, CD34, and CD200 in leukemia cells are significantly correlated with the OS of APL patients, and the high expression of these indicators before treatment may be an adverse prognostic factor for APL patients.

The CD2 cytoplasmic tail, in combination with CD3z, delivers balanced costimulation that couples brisk tumor debulking to T cell persistence. CD2z therefore may provide a simple, versatile alternative to canonical CD28 and 4-1BB modules for next-generation CAR T therapies.

Since urease was introduced onto the electrode in the presence of target miRNAs, this target-gated ECL sensing strategy was established with a wide linear detection range from 1.0 fM to 1.0 nM for the thyroid cancer marker miRNA-146b-5p, and a detection limit as low as 0.59 fM, along with concise operation and rapid response. The target-gated generation of MOF emitters not only achieved unprecedented specificity and exceptional signal-to-noise ratio, but also expanded the applications of MOF-based ECL in biosensing.

Although horsetail tea is associated with liver injury, its contribution to ALF remains insufficiently defined, reinforcing the importance of excluding alternative causes. ENKTL and other malignancies should be considered in indeterminate ALF, even without imaging findings, atypical lymphocytes in peripheral blood/ascites, or overt clinical suspicion of malignancy.

The identified key genes were supported by evidence in the literature, highlighting their involvement in antitumor processes in T cells and other immune cells. Our findings provide valuable insights into the transcriptional signatures of immune cells in different cancer types and lay the foundation for the development of novel diagnostic, prognostic, and therapeutic strategies in cancer immunology.

P1, N=30, Suspended, National Cancer Institute (NCI) | Recruiting --> Suspended

Interactome analysis of the joints showed that in a second step, resident regulatory CD200+ fibroblasts regulate the priming of CD2+MHC-II+CCR2+ myeloid precursors, which subsequently control IL-17 expression in T cells. Hence, the spread of inflammation requires a distinct migratory myeloid precursor population and a permissive local tissue environment, similar to tumor metastasis.

Despite partial responses to topical therapies, oral prednisone, and methotrexate, the disease persisted, highlighting therapeutic challenges. This case underscores the importance of molecular profiling in PCAECTCL and suggests potential utility for JAK inhibitors like ruxolitinib.

This study uncovers both shared and ancestry-specific immunogenomic features of breast cancer, highlighting the role of ancestry and other biological features in shaping the tumor immune microenvironment. These findings re-emphasize the need for population-informed approaches in breast cancer immunotherapy and biomarker development, to ensure equitable precision oncology strategies across global populations.

A trial of flucloxacillin produced no improvement, and an urgent ultrasound revealed nonspecific skin thickening, prompting a skin biopsy...In this case, the absence of systemic involvement on imaging and the atypical immuno-phenotypic features underscore the complexity of distinguishing between tumour-stage MF and PCGDTCL. This case highlights the role of detailed histopathological evaluation of rare cutaneous lymphomas and emphasizes the need for a multidisciplinary approach to design both local and systemic treatment strategies for individual patients.