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    BIOMARKER:

    CD177 expression

    i
    Other names: CD177, CD177 Molecule, PRV1, NB1, CD177 Antigen, HNA2A, Polycythemia Rubra Vera Protein 1, Human Neutrophil Alloantigen 2a, NB1 Glycoprotein, HNA-2a, NB1 GP, PRV-1, Polycythemia Rubra Vera 1, Cell Surface Receptor
    Entrez ID:
    57126
    9ms
    CD177 drives the transendothelial migration of Treg cells enriched in human colorectal cancer. (PubMed, Clin Transl Immunology)
    These results demonstrated that Treg cells with higher CD177 levels exhibited an enhanced activation status and transendothelial migration capacity. Our findings suggest that CD177 may serve as an immunotherapeutic target and that overexpression of CD177 may improve the efficacy of chimeric antigen receptor T (CAR-T) cell therapy.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-1 (Programmed cell death 1) • CD177 (CD177 Molecule)
    |
    CD177 expression
    9ms
    Lymphatic endothelial cell-mediated accumulation of CD177+Treg cells suppresses antitumor immunity in human esophageal squamous cell carcinoma. (PubMed, Oncoimmunology)
    Finally, we found that lymphatic endothelial cells are associated with CD177+ Treg cell accumulation in ESCC tumors, which are also decreased after anti-PD-1 immunotherapy plus chemotherapy. Our work identifies CD177+ Treg cell as a tumor-specific Treg cell subset and highlights their potential value as a prognostic marker of survival and response to immunotherapy and a therapeutic target in ESCC.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    CD8 (cluster of differentiation 8) • IL10 (Interleukin 10) • CD177 (CD177 Molecule)
    |
    CD177 expression
    over1year
    Identification of the shared gene signatures and molecular pathways in systemic lupus erythematosus and diffuse large B-cell lymphoma. (PubMed, J Gene Med)
    Our study provides valuable insights into the shared molecular mechanisms underpinning the pathogenesis of SLE and DLBCL. These findings could potentially offer new biomarkers and therapeutic targets for SLE and DLBCL.
    Journal • Gene Signature
    |
    TP53 (Tumor protein P53) • CD177 (CD177 Molecule) • CEACAM1 (CEA Cell Adhesion Molecule 1)
    |
    TP53 mutation • TP53 expression • CD177 expression
    2years
    Diagnostic, prognostic, and immunological roles of CD177 in cervical cancer. (PubMed, J Cancer Res Clin Oncol)
    These findings may shed light on the vital role of CD177 in cervical cancer diagnosis, prognosis, and immunological functions, and it may be a promising predictor and potential factor for cervical cancer patients.
    Journal • IO biomarker
    |
    CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • ICOS (Inducible T Cell Costimulator) • CD200 (CD200 Molecule) • CD27 (CD27 Molecule) • CD177 (CD177 Molecule) • CD40 (CD40 Molecule) • NRP1 (Neuropilin 1) • CD80 (CD80 Molecule)
    |
    CD177 expression
    |
    gefitinib • lapatinib • tamoxifen • navitoclax (ABT 263) • Beleodaq (belinostat)