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    BIOMARKER:

    CD163 underexpression

    i
    Other names: CD163, CD163 Molecule, M130, Scavenger Receptor Cysteine-Rich Type 1 Protein M130, Hemoglobin Scavenger Receptor, CD163 Antigen, SCARI1, MM130, Macrophage-Associated Antigen
    Entrez ID:
    9332
    Related biomarkers:
    Expression
    Others
    3ms
    Integrative analysis of H&E and IHC identifies prognostic immune subtypes in HPV related oropharyngeal cancer. (PubMed, Commun Med (Lond))
    Integrating H&E and IHC data enhances the functional characterization of immune phenotypes of the TME with biological interpretability, and improves patient stratification in HPV( + ) OPSCC.
    Journal
    |
    CD8 (cluster of differentiation 8) • CD163 (CD163 Molecule)
    |
    CD8 expression • CD8-H • CD163 expression • CD163 underexpression
    almost2years
    Functional status of tumor-associated macrophages impacts clinical outcome of durvalumab in patients with advanced NSCLC as revealed by proteomics mass spectrometry (AACR 2023)
    This analysis further confirms the importance of myeloid cell function within the tumor microenvironment (TME) in determining the outcome to T cell-directed IO therapy and highlights the utility of proteomics mass spectrometry in assessing more broadly and quantitatively the TME complementing findings based on RNAseq and IHC/mIF assays.
    Clinical • Clinical data • PD(L)-1 Biomarker • IO biomarker • Metastases
    |
    CD8 (cluster of differentiation 8) • CD163 (CD163 Molecule) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • CD68 (CD68 Molecule)
    |
    PD-L1 overexpression • CD163 expression • CD163 underexpression • PD-L1 overexpression + CD163 underexpression
    |
    Imfinzi (durvalumab)
    almost3years
    CD40 Agonists Alter the Pancreatic Cancer Microenvironment by Shifting the Macrophage Phenotype toward M1 and Suppress Human Pancreatic Cancer in Organotypic Slice Cultures. (PubMed, Gut Liver)
    CD163 is related to advanced human pancreatic cancer stages and shorter overall survival. CD40 agonists alter macrophage phenotype polarization to favor the M1 phenotype and suppress human pancreatic cancer.
    Journal • IO biomarker
    |
    CD163 (CD163 Molecule) • FOXP3 (Forkhead Box P3) • CD40 (CD40 Molecule)
    |
    CD163 expression • CD163 underexpression