CD163 overexpression

This study elucidated the polarization status and regulatory characteristics of macrophages in ovarian tissues of the PCOS subjects, confirming significant overexpression of CD163, TREM1, and TREM2. These findings contribute to a deeper understanding of the pathogenesis of PCOS.

The ameliorative effects of Hesp and Nio + Hesp may be at least in part due to their antioxidant and anti-inflammatory properties. These findings showed that both M1- and M2-macrophages contributed to the development of hepatic lesions induced by CPF and provided information about macrophage activation, indicating the importance of analysis of macrophage phenotypes for hepatotoxicity based on M1/M2-polarization which can be downregulated by niosomal nesperidin.

However, sensitivity to Erlotinib was correlated with high expression of PF4 and PPBP. In summary, FLT3, PF4, CD163, MRC1, CSF2RB, PPBP may be potential biomarkers and potential sensitive small-molecule drugs were correlated with overexpression of the biomarkers in AML.

Moreover, pharmacological inhibition of SCARB1 using a novel compound (ITX-5061) results in decreased ccRCC cell proliferation in vitro...The impact of this KCRP Idea Development Application comes from the pressing need for new therapeutic strategies, given that targeted therapies, anti-angiogenics, immunotherapies, and other metabolic strategies (such as targeting glutamine metabolism) only serve subsets of patients, even in combination, and altered cholesterol metabolism is a universal feature of ccRCC. Finally, as HIF-2alpha antagonists continue to be tested in ongoing clinical trials, SCARB1 inhibition could be deployed in patients ultimately acquiring resistance to HIF-2alpha-specific drugs, as previously demonstrated in preclinical studies.

In the simulated in vitro tumor microenvironment, co-cultured ovarian cancer cells polarized macrophages to the M2 phenotype. Furthermore, M2 macrophages enhanced the proliferation, invasion and migration, and inhibited the apoptosis of ovarian cancer cells.