CD151 (CD151 Molecule)

Furthermore, conditioned media from the treated BC cells induced the proliferation of PMA treated monocyte like THP-1 cells and provoked the secretion of IL-6, while reducing IL-10. These findings suggest that the CD151-LEL-based peptides and their engineered multiepitope construct represent a prospective vaccine candidate for in vivo experimental validation, which can be used as a therapeutic vaccine for breast cancer.

[This retracts the article DOI: 10.3892/ol.2021.12693.].

This review focuses on natural flavonoids such as quercetin, taxifolin, and rutin. We discuss how these bioactive compounds potentially mitigate metastasis and associated signaling pathways in colon cancer.

STT3B is a key player in the production and modification of N-glycans, and a low level of STT3B therefore results in a predominant expression of non-glycosylated CD151 and in the accumulation of oligomannose-type glycans in CD151. The results suggest that the expression of the non-glycosylated form of CD151 confers an invasive phenotype to cancer cells, and as such, it could be a therapeutic target to block metastasis in breast cancer.

Our study unveils a previously uncharacterized mechanism by which T. vaginalis exacerbates HPV infection: TvAP65 hijacks SPCS1 to transcriptionally upregulate CD151 and HSPG2, thereby facilitating HPV entry into host cells. This TvAP65-SPCS1-CD151/HSPG2 axis highlights potential therapeutic targets to disrupt the synergy between HPV and T. vaginalis, offering new strategies for cervical cancer prevention.

The review sheds light on the pharmacology and specific properties of cyclo(L-Leu-L-Pro), which can be useful for the development of a novel therapeutic approach for different human pathologies. It is also of interest to help define the bioactivity and mechanisms of action of closely related DKP-based natural products.

This study identifies P. gingivalis as a tumor-associated bacterium that promotes CSCC metastasis through direct interaction between its fimbrial adhesin FimA and the host CD151/ITGB1 complex. This interaction activates JNK/paxillin signaling, induces cytoskeletal reorganization, and enhances the metastatic capacity of CSCC cells. Targeting this microbial-host interaction may provide a novel therapeutic intervention for P. gingivalis-driven CSCC metastasis.

Finally, in patients with non-Hodgkin lymphoma (NHL), we observed a correlation between NK cell maturation status and progression-free survival. Collectively, our findings provide valuable insights into NK cell dynamics during immune reconstitution following autoHSCT and may inform of strategies for improving patients' management.

Perindopril inhibits myocardial apoptosis in mice with acute myocardial infarction through TLR4/NF-κB pathway...SNHG7 mediates cisplatin-resistance in non-small cell lung cancer by activating PI3K/AKT pathway...Natural killer cell-derived exosome-entrapped paclitaxel can enhance its anti-tumor effect...Antidiabetic drug metformin mitigates ovarian cancer SKOV3 cell growth by triggering G2/M cell cycle arrest and inhibition of m-TOR/PI3K/Akt signaling pathway...These articles have been retracted. The Publisher apologizes for any inconvenience this may cause.

Additionally, the CD151 exosome induced higher mRNA expression of cyclin D1, CDK4, CDK6, MMP-2, and MMP-9 in MCF-7 cells and VEGF in endothelial cells compared to iCD151 exosomes. These findings demonstrate the potential role of CD151 in orchestrating exosome dynamics for the remodelling of either the adjacent tissue or those in distant organs by transferring metastatic phenotypes from TNBC cells to recipient cells.

Our study revealed that SCAFs were strongly correlated with cancer stemness in HCC. A novel machine learning model based on senescent CAF-related genes was constructed to accurately predict prognosis in HCC patients. Furthermore, CTHRC1 was identified as a novel prognostic and therapeutic biomarker to predict poor prognosis in HCC and promote cancer stemness and metastasis through the Notch signaling pathway, with its expression being transcriptionally regulated by SOX4.

This study established a multi-omics platform to detect the genes-hormone interactions, and evaluate expression dynamics of 14 key regulators across gonadal stages and sexes in R philippinarum, concurrently evaluating steroid hormones roles. These findings provide valuable resources for further research into the comprehensive regulatory mechanisms governing gonad development in clams.