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    BIOMARKER:

    CD14 overexpression

    i
    Other names: CD14
    Entrez ID:
    929
    Related biomarkers:
    Expression
    over1year
    Cyclin dependent kinase 14 as a paclitaxel-resistant marker regulated by the TGF-β signaling pathway in human ovarian cancer. (PubMed, J Cancer)
    These data indicate that CDK14 is a PTX-resistant marker and is regulated by the TGF-β signaling pathway. Targeting CDK14 to enhance the sensitivity of PTX may provide a new therapeutic strategy for reversing the PTX resistance in OC.
    Journal
    |
    ABCB1 (ATP Binding Cassette Subfamily B Member 1) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • CD14 (CD14 Molecule) • TGFB1 (Transforming Growth Factor Beta 1) • CDK14 (Cyclin Dependent Kinase 14) • SMAD2 (SMAD Family Member 2)
    |
    CD14 overexpression • CD14 expression • CDK14 overexpression
    |
    paclitaxel
    over1year
    miR-1-3p Inhibits Osteosarcoma Cell Proliferation and Cell Cycle Progression While Promoting Cell Apoptosis by Targeting CDK14 to Inactivate Wnt/Beta-Catenin Signaling. (PubMed, Mol Biotechnol)
    CDK14 overexpression partially rescued the inhibitory impact of miR-1-3p on OS cell growth. Overall, miR-1-3p inhibits OS cell proliferation and cell cycle progression while promoting cell apoptosis by targeting CDK14 and inactivating the Wnt/beta-catenin signaling.
    Journal
    |
    CD14 (CD14 Molecule) • CDK14 (Cyclin Dependent Kinase 14)
    |
    CD14 overexpression • CD14 expression • CDK14 overexpression • CTNNB1 expression
    3years
    CDK14 expression is elevated in patients with non-small cell lung cancer and correlated with poor prognosis. (PubMed, J Int Med Res)
    CDK14 overexpression portended poor outcomes in patients with NSCLC, and CDK14 expression was correlated with TTF-1, CK5/5, and Ki67 expression.
    Clinical • Observational data • Journal
    |
    NKX2-1 (NK2 Homeobox 1) • CD14 (CD14 Molecule) • CDK14 (Cyclin Dependent Kinase 14) • KRT5 (Keratin 5)
    |
    CD14 overexpression • CD14 expression • CDK14 overexpression
    over3years
    CDK14/β-catenin/TCF4/miR-26b positive feedback regulation modulating pancreatic cancer cell phenotypes in vitro and tumor growth in mice model in vivo. (PubMed, J Gene Med)
    CDK14, β-catenin, TCF4, and miR-26b form a positive feedback regulation to modulate pancreatic cancer cell phenotypes in vitro and tumor growth in vivo.
    Preclinical • Journal
    |
    CD14 (CD14 Molecule) • CDK14 (Cyclin Dependent Kinase 14) • GSK3B (Glycogen Synthase Kinase 3 Beta)
    |
    CD14 overexpression • CD14 expression • CDK14 overexpression
    |
    gemcitabine