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CD133 expression
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Other names: RP41, AC133, CD133, MCDR2, STGD4, CORD12, PROML1, MSTP061, Prominin 1
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10h
Beta hydroxybutyrate induces lung cancer cell death, mitochondrial impairment and oxidative stress in a long term glucose-restricted condition. (PubMed, Mol Biol Rep)
The induced cell death, oxidative stress and mitochondria impairment beside attenuated levels of cancer stem cell markers following BHB administration emphasize on the distinctive role of metabolic plasticity of cancer cells and propose possible therapeutic approaches to control cancer cell growth through metabolic fuels.
Journal
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CTNNB1 (Catenin (cadherin-associated protein), beta 1) • CD44 (CD44 Molecule)
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CD44 expression • CD133 expression • SOX9 expression
1d
Decorin suppresses stemness and migration potential of malignant peripheral nerve sheath tumor through inhibiting epidermal growth factor receptor signaling. (PubMed, Biochim Biophys Acta Mol Basis Dis)
Decorin-negative MPNST cells grew significantly larger tumor in vivo. Thus, depletion of Decorin may occur in CSCs in MPNSTs, serving possibly as a new therapeutic target.
Journal
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EGFR (Epidermal growth factor receptor) • CD44 (CD44 Molecule) • DCN (Decorin)
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CD44 expression • CD133 expression • CD133 positive • CD44 positive
7d
Expressions and Clinical Significance of Met and YAP in Gastric Cancer Tissue Microarray. (PubMed, Gastroenterol Res Pract)
The expressions of Met and YAP are closely associated with the survival outcomes as well as clinicopathological features in patients with gastric cancer. Moreover, our findings highlight that Met serves as an independent prognostic factor for gastric cancer.
Journal
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MET (MET proto-oncogene, receptor tyrosine kinase)
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MET expression • CD133 expression
27d
Role of sodium/iodide symporter overexpression in inhibiting thyroid cancer cell invasion and stem cell maintenance by inhibiting the β-catenin/LEF-1 pathway. (PubMed, Heliyon)
Thyroid cancer cells exhibit diminished expression of NIS, and the invasion and maintenance of stem cells in thyroid cancer cells were hindered by NIS OE through the inhibition of the β-catenin/LEF-1 pathway. Further research is warranted to comprehensively assess this outcome, which holds promise as a potential targeted treatment for thyroid cancer.
Journal
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SOX2 • POU5F1 (POU Class 5 Homeobox 1) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • NANOG (Nanog Homeobox) • TCF4 (Transcription Factor 4)
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CD133 expression • POU5F1 expression
30d
Metadherin promotes stem cell phenotypes and correlated with immune infiltration in hepatocellular carcinoma. (PubMed, World J Gastroenterol)
High levels of MTDH expression in patients with HCC are associated with poor prognosis, promoting tumor stemness, immune infiltration, and HCC progression.
Journal
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CD8 (cluster of differentiation 8) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • CD4 (CD4 Molecule) • CX3CL1 (C-X3-C Motif Chemokine Ligand 1) • MTDH (Metadherin)
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CD133 expression • CXCL12 expression
30d
CD44 and CD133 protein expression might serve as a prognostic factor for early occurrence castration-resistant prostate cancer. (PubMed, Prostate)
This study found a low expression of at least one CD44/CD133 protein in the patients without early occurrence of CRPC. This result might suggest that CD44/CD133 may function as a potential prognostic marker for PCa, especially in a low expression, to identify patients who have a better prognosis regarding the occurrence of early CRPC.
Journal
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CD44 (CD44 Molecule)
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CD44 expression • CD133 expression
1m
Scutellarin, a flavonoid compound from Scutellaria barbata, suppresses growth of breast cancer stem cells in vitro and in tumor-bearing mice. (PubMed, Phytomedicine)
Our study demonstrated for the first time that both SB water extract and scutellarin could reduce the proliferation and migration of BCSCs in vitro. Scutellarin was shown to possess novel inhibitory activities in BCSCs progression. These findings suggest that Scutellaria barbata water extract, in particular, scutellarin, may have potential to be further developed as an adjuvant therapy for reducing breast cancer recurrence.
Preclinical • Journal • Cancer stem
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PTEN (Phosphatase and tensin homolog) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • CD44 (CD44 Molecule) • CD24 (CD24 Molecule) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1)
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CD44 expression • CD133 expression
1m
FEN1 upregulation mediated by SUMO2 via antagonizing proteasomal degradation promotes hepatocellular carcinoma stemness. (PubMed, Transl Oncol)
In summation, our research elucidates that protein FEN1 is an effector in augmenting the stemness of LCSCs. Consequently, strategic attenuation of protein FEN1 might proffer a pioneering approach for the efficacious elimination of LCSCs.
Journal
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FEN1 (Flap Structure-Specific Endonuclease 1)
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CD133 expression
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MG132
1m
N6-methyladenosine reader hnRNPA2B1 recognizes and stabilizes NEAT1 to confer chemoresistance in gastric cancer. (PubMed, Cancer Commun (Lond))
Our findings indicated that hnRNPA2B1 interacts with and stabilizes lncRNA NEAT1, which contribute to the maintenance of stemness property via Wnt/β-catenin pathway and exacerbate chemoresistance in GC.
Journal
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NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) • HNRNPAB (Heterogeneous Nuclear Ribonucleoprotein A/B) • HNRNPA2B1 (Heterogeneous Nuclear Ribonucleoprotein A2/B1)
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CD133 expression
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5-fluorouracil
1m
Pituitary tumours without distinct lineage differentiation express stem cell marker SOX2. (PubMed, Pituitary)
Our study is the first to biologically characterise pituitary tumours WDLD. We demonstrate that these tumours exhibit a higher expression of the stem cell marker SOX2 compared with other lineage-differentiated tumours, suggesting possible involvement of stem cells in their development.
Journal
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SOX2 • NES (Nestin)
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CD33 positive • CD133 expression • CD133 positive
1m
GTP binding protein 2 maintains the quiescence, self-renewal, and chemoresistance of mouse colorectal cancer stem cells via promoting Wnt signaling activation. (PubMed, Heliyon)
GTPBP2 deficiency caused the following effects on CCSCs: 1) Significantly accelerating proliferation and increasing the proportions of cells at G1, S, and G2/M phase; 2) Impairing resistance to 5-Fluorouracil; 3) Weakening self-renewal but not impacting cell migration...Collectively, this study indicates that GTPBP2 positively modulates Wnt signaling to reinforce the quiescence, self-renewal, and chemoresistance of mouse CCSCs. Therefore, we disclose a novel mechanism underlying CCSC biology and GTPBP2 could be a therapeutic target in future CRC treatment.
Preclinical • Journal • Cancer stem
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CTNNB1 (Catenin (cadherin-associated protein), beta 1)
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CD44 expression • CD133 expression
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5-fluorouracil
1m
CD133 significance in glioblastoma development: in silico and in vitro study. (PubMed, Eur J Med Res)
CD133 can regulate the PI3K/Akt and MAPK pathways and modulate the clonogenicity, apoptosis, and cell cycle of GBM. Combining CD133 silencing with temozolomide treatment considerably increases apoptosis, arrests the cell cycle at the sub-G1, and suppresses migration of U87MG cells compared to temozolomide monotherapy.
Preclinical • Journal • IO biomarker
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PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • BCL2 (B-cell CLL/lymphoma 2) • MAP2K1 (Mitogen-activated protein kinase kinase 1) • mTOR (Mechanistic target of rapamycin kinase) • CDK4 (Cyclin-dependent kinase 4) • SOX2 • ANXA5 (Annexin A5) • MAPK3 (Mitogen-Activated Protein Kinase 3) • MMP16 (Matrix Metallopeptidase 16)
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PIK3CA expression • CD133 expression
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temozolomide
2ms
Correlation analysis of cancer stem cell marker CD133 and human endogenous retrovirus (HERV)-K env in SKOV3 ovarian cancer cells. (PubMed, Genes Genomics)
These findings indicate that the expression of HERV-K env increased in SKOV3 cells when cultured in cancer stem cell induction media, and cancer stem cell induction was inhibited by KO of HERV-K env in SKOV3 cells. These results suggest a strong association between HERV-K env and stemness in SKOV3 ovarian cancer cells.
Journal • Cancer stem
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POU5F1 (POU Class 5 Homeobox 1) • NANOG (Nanog Homeobox)
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CD133 expression • POU5F1 expression
2ms
Vitamin D suppresses CD133+/CD44 + cancer stem cell stemness by inhibiting NF-κB signaling and reducing NLRP3 expression in triple-negative breast cancer. (PubMed, Cancer Chemother Pharmacol)
Findings elucidate that VD mediates the modulation of stemness in CD133+/CD44 + breast cancer stem cells through the regulation of NLRP3 expression. The research represents novel insights on the implications for the application of VD in cancer therapies.
Journal • Cancer stem
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CD44 (CD44 Molecule) • SOX2 • POU5F1 (POU Class 5 Homeobox 1) • NLRP3 (NLR Family Pyrin Domain Containing 3) • RELA (RELA Proto-Oncogene) • VDR (Vitamin D Receptor)
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CD44 expression • CD133 expression • SOX2 expression • POU5F1 expression
2ms
Arsenic trioxide suppresses lung adenocarcinoma stem cell stemness by inhibiting m6A modification to promote ferroptosis. (PubMed, Am J Cancer Res)
Finally, ZC3H13 overexpression alleviated the inhibitory effects of ATO on LASCs tumorigenicity. Taken together, ATO treatment substantially impaired the stemness of LUAD stem cells by promoting the ferroptosis program, which was mediated by its ZC3H13 gene expression inhibition to suppress m6A medication.
Journal
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EGF (Epidermal growth factor) • ZC3H13 (Zinc Finger CCCH-Type Containing 13)
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CD133 expression
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arsenic trioxide
2ms
Consolidating Organometallic Complex Ir-CA Empowers Mitochondria-Directed Chemotherapy against Resistant Cancer via Stemness and Metastasis Inhibition. (PubMed, Inorg Chem)
Over 80% of Ir-CA could accumulate in mitochondria, result in severe mitochondrial dysfunctions, and subsequently initiate mitophagy and cell cycle arrest to kill cisplatin-resistant A549R cells...In vivo evaluation indicated that Ir-CA restrains the tumor growth and has minimal side effects and superior biocompatibility. This work not only provides the first three-in-one agent to attenuate cancer cell stemness and simultaneously realize anticancer, antimetastasis, and conquer metallodrug resistance but also demonstrates the effectiveness of the mitochondria-directed strategy in cancer treatment.
Journal
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GSTP1 (Glutathione S-transferase pi 1) • MMP2 (Matrix metallopeptidase 2) • MMP9 (Matrix metallopeptidase 9)
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CD133 expression
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cisplatin
2ms
Dissecting circulating tumor cells phenotype in a cohort of locally advanced non-small cell lung cancer patients undergoing neoadjuvant chemotherapy (AACR 2024)
Cisplatin-induced cell damage has been shown to activate the SDF-1/CXCR4 axis in preclinical models of NSCLC, resulting in the recruitment of a cell subset co-expressing the stemness marker CD133 and CXCR4 (SDF-1 receptor) at distant sites... Out of the 61 enrolled patients, 34 had available CTC data for analysis. In this population, DCR was 64.7%, and the ORR 29.4%. Surgery was performed in 14 pts (41.2%).
Clinical • Circulating tumor cells • Tumor cell • Metastases
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CXCL12 (C-X-C Motif Chemokine Ligand 12)
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CD133 expression
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Parsortix Liquid Biopsy
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cisplatin
2ms
Colibactin-producing Escherichia coli enhance resistance to chemotherapeutic drugs by promoting epithelial to mesenchymal transition and cancer stem cell emergence. (PubMed, Gut Microbes)
In agreement with these results, murine and human CRC biopsies colonized with CoPEC exhibited higher expression levels of OCT-3/4 and NANOG than biopsies devoid of CoPEC. CoPEC might aggravate CRCs by inducing the emergence of cancer stem cells that are highly resistant to chemotherapy.
Journal • Cancer stem
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NANOG (Nanog Homeobox)
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CD133 expression • CD133 overexpression
2ms
High CD133 expression in proximal tubular cells in diabetic kidney disease: good or bad? (PubMed, J Transl Med)
Our study demonstrates that the upregulation of CD133 is linked to cellular proliferation and protects PTC from apoptosis in DKD and high glucose induced PTC injury. We propose that heightened CD133 expression may facilitate cellular self-protective responses during the initial stages of high glucose exposure. However, its sustained increase is associated with the pathological progression of DKD. In conclusion, CD133 exhibits dual roles in the advancement of DKD, necessitating further investigation.
Journal
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TNFA (Tumor Necrosis Factor-Alpha) • CD24 (CD24 Molecule) • KIM1 (Kidney injury molecule 1) • SOX9 (SRY-Box Transcription Factor 9) • PCNA (Proliferating cell nuclear antigen)
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CD133 expression • CD133 overexpression • CD24 expression • SOX9 expression • PCNA expression
2ms
PARD3 drives tumorigenesis through activating Sonic Hedgehog signalling in tumour-initiating cells in liver cancer. (PubMed, J Exp Clin Cancer Res)
This study revealed PARD3 as a potential preventive target of liver tumorigenesis via TIC regulation.
Journal
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GLI1 (GLI Family Zinc Finger 1) • SOX2 • PARD3 (Par-3 Family Cell Polarity Regulator)
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CD133 expression • CD133 overexpression • PARD3 expression • PARD3 overexpression
3ms
Molecular signature of stem-like glioma cells (SLGCs) from human glioblastoma and gliosarcoma. (PubMed, PLoS One)
Spherical growth, however, was positively correlated with high levels of Hif1α, CDK4, PTEN, and PDGFRβ, whereas correlations with stemness factors or MGMT (MGMT expression and promoter methylation) were low or missing. Factors highly expressed by all SLGC lines, irrespective of their degree of stemness and growth behavior, are Cathepsin-D, CD99, EMMPRIN/CD147, Intβ1, the Galectins 3 and 3b, and N-Cadherin.
Journal
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EGFR (Epidermal growth factor receptor) • PTEN (Phosphatase and tensin homolog) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • MGMT (6-O-methylguanine-DNA methyltransferase) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • CDK4 (Cyclin-dependent kinase 4) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • SOX2 • CDH2 (Cadherin 2) • CD99 (CD99 Molecule) • CTSD (Cathepsin D) • FABP7 (Fatty Acid Binding Protein 7) • BSG (Basigin (Ok Blood Group)) • GFAP (Glial Fibrillary Acidic Protein)
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IDH wild-type • CD133 expression • HIF1A expression • MGMT expression • SOX2 expression
3ms
CD133, CD47, and PD-L1 Expression in Ovarian High-grade Serous Carcinoma and Its Association with Metastatic Disease: A Cross-sectional Study. (PubMed, Asian Pac J Cancer Prev)
Our findings suggested that expression of CD133, CD47, and PD-L1 may have dynamically increased as the primary lesion progressed to the metastatic lesion, implying that these proteins may be involved in the progression of high-grade serous ovarian cancer from the primary to the metastatic stage.
Observational data • Journal • PD(L)-1 Biomarker • IO biomarker • Metastases
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PD-L1 (Programmed death ligand 1) • CD47 (CD47 Molecule)
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PD-L1 expression • PD-L1 negative • CD133 expression • CD47 expression
3ms
Effect of Pioglitazone and Cetuximab on Colon Cancer Stem-like Cell (CCSLCs) Properties. (PubMed, Curr Stem Cell Res Ther)
Pio and Cet could inhibit EMT and reduce CSC markers in the EMT induced/CSC enriched cell line. We expect that focus on finding EMT/CSC-targeting agents like these drugs can be helpful for cancer treatment.
Journal
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CDH1 (Cadherin 1) • VIM (Vimentin)
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CD44 expression • CDH1 expression • CD133 expression • VIM expression
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Erbitux (cetuximab)
3ms
Impact of heterogeneous nuclear ribonucleoprotein A/B subtype overexpression on the expression of cancer stem cell markers CD133 and CD44 and cellular proliferation capacity. (PubMed, Cell Mol Biol (Noisy-le-grand))
The invasive, migratory, and proliferative abilities of cells in group E were notably enhanced, and tumor growth was observably faster versus group C. OP of hnRNPA1 was closely associated with the activation of Wnt/β-catenin signaling and promoted the proliferation and invasive capacity of tumor cells. hnRNPA1 played an imperative role in intestinal cancer stem cells.
Journal • Cancer stem
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CCND1 (Cyclin D1) • HNRNPAB (Heterogeneous Nuclear Ribonucleoprotein A/B)
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CD133 expression • HNRNPD overexpression
3ms
Expression of stem cell markers as predictors of therapeutic response in metastatic prostate cancer patients. (PubMed, Urol Oncol)
Combination therapy involving chemotherapy and ADT appears to have a greater impact on suppressing CSCs compared to ADT alone. These findings highlight the potential of targeting CSCs as a prognostic and predictive marker therapeutic strategy in metastatic PCA.
Journal • Metastases
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CD24 (CD24 Molecule)
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CD133 expression
3ms
A telomere-targeting drug depletes cancer initiating cells and promotes anti-tumor immunity in small cell lung cancer. (PubMed, Nat Commun)
We also observe increased sensitivity to irradiation after 6TdG treatment in both syngeneic and humanized SCLC xenograft models both of which are dependent on the presence of host immune cells. This study underscores the immune-enhancing and metastasis-reducing effects of 6TdG, employing a range of complementary in vitro and in vivo SCLC preclinical models providing a potential therapeutic approach to SCLC.
Journal
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L1CAM (L1 cell adhesion molecule)
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CD133 expression
3ms
A novel approach for transforming breast cancer stem cells into endothelial cells. (PubMed, Exp Ther Med)
FISH was used to verify MDM2/CEN12 gene amplification in the induced MCF-7 cells, indicating tumor cell characteristics. The modified endothelial cell transformation medium effectively induced differentiated tumor stem cells to express vascular endothelial cell markers and exhibit endothelial functions, ideal for in vitro anti-angiogenesis research.
Journal • Cancer stem
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MDM2 (E3 ubiquitin protein ligase) • CD31 (Platelet and endothelial cell adhesion molecule 1) • ENG (Endoglin) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1)
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CD133 expression • CD31 expression
3ms
PYGO2 increases proliferation and migration capacities through critical signaling pathways in esophageal squamous cell carcinoma. (PubMed, J Biochem Mol Toxicol)
Overexpression of the PYGO2 protein resulted in the upregulation of Wnt pathway-related genes, leading to enhanced cell migration and proliferation and reduced apoptosis in both cell lines. Furthermore, PYGO2 gene expression induction analysis showed the correlation of several involved genes in Wnt, Hh, Apoptosis, MAPK, EGFR, AKT, and EMT pathways with various LncRNAs.
Journal
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CD44 (CD44 Molecule)
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CD44 expression • CD133 expression
3ms
Study on the Mechanism of Notch Pathway Mediates the Role of Lenvatinib-resistant Hepatocellular Carcinoma Based on Organoids. (PubMed, Curr Mol Med)
Lenvatinib regulated resistance and stemness in organoids via the Notch pathway.
Journal
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NOTCH1 (Notch 1) • CD44 (CD44 Molecule) • THY1 (Thy-1 membrane glycoprotein)
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CD44 expression • NOTCH1 expression • CD133 expression
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Lenvima (lenvatinib)
3ms
Transforming Growth Factor-β/Smad Signaling Inhibits Melanoma Cancer Stem Cell Self-Renewal, Tumor Formation and Metastasis. (PubMed, Cancers (Basel))
Using preclinical models of melanoma, we further showed that preventing Smad3/4 signaling, by means of CRISPR knockouts, promoted both tumorigenesis and lung metastasis in vivo. Collectively, our results define new functions for the TGFβ/Smad signaling axis in melanoma stem-cell maintenance and open avenues for new therapeutic approaches to this disease.
Journal • Cancer stem
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SMAD3 (SMAD Family Member 3)
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CD133 expression
4ms
Can CD133 Be Regarded as a Prognostic Biomarker in Oncology: Pros and Cons. (PubMed, Int J Mol Sci)
This review summarizes and discusses the existing evidence for and against the prognostic significance of CD133 in cancer. We also consider possible reasons for conflicting findings from the studies of the clinical significance of CD133.
Review • Journal
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PROM1 (Prominin 1)
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CD133 expression • CD133 positive
4ms
Chaperonin containing TCP1 subunit 6A may activate Notch and Wnt pathways to facilitate the malignant behaviors and cancer stemness in oral squamous cell carcinoma. (PubMed, Cancer Biol Ther)
Importantly, it was shown that activation of the Wnt or Notch pathways attenuated the effect of CCT6A knockout on SCC-15 cell survival, invasion, and stemness. CCT6A may promote OSCC malignant behavior and stemness by activating the Wnt and Notch pathways.
Journal
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NOTCH1 (Notch 1) • SOX2
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CD133 expression • SOX2 expression • NOTCH1 overexpression
5ms
Prognostic model for assessing the human glioma cell malignancy grade based on MDM2, MELK, SOX2, CDK4, DR5 and OCT4 gene expression. (PubMed, Zh Vopr Neirokhir Im N N Burdenko)
We obtained a prognostic model for assessing the grade III and IV glioma cell malignancy based on expression of marker genes MDM2, MELK, SOX2, CDK4, DR5 and OCT4. Predictive accuracy was 83% (Akaike information criterion -55.125).
Journal
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EGFR (Epidermal growth factor receptor) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • FGFR (Fibroblast Growth Factor Receptor) • MDM2 (E3 ubiquitin protein ligase) • CDK4 (Cyclin-dependent kinase 4) • NOTCH2 (Notch 2) • TUBB3 (Tubulin beta 3 class III) • CDK6 (Cyclin-dependent kinase 6) • SOX2 • POU5F1 (POU Class 5 Homeobox 1) • MELK (Maternal Embryonic Leucine Zipper Kinase) • PDGFA (Platelet Derived Growth Factor Subunit A) • PDGFB (Platelet Derived Growth Factor Subunit B) • L1CAM (L1 cell adhesion molecule) • NANOG (Nanog Homeobox) • GFAP (Glial Fibrillary Acidic Protein) • OLIG2 (Oligodendrocyte Transcription Factor 2)
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CD133 expression • CDK6 expression
5ms
Periostin facilitates ovarian cancer recurrence by enhancing cancer stemness. (PubMed, Sci Rep)
Taken together, these results show that elevated POSTN in the extracellular environment leads to more aggressive OC cell behavior and an increase in cancer stemness, suggesting that increased levels of stromal POSTN during OC recurrence contribute to more rapid disease progression and may be a novel therapeutic target. Furthermore, they also demonstrate the utility of having matched primary-recurrent OC tissues for analysis and support the need for better understanding of the molecular changes that occur with OC recurrence to develop ways to undermine those processes.
Journal
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FASN (Fatty acid synthase) • POSTN (Periostin)
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CD133 expression
5ms
Prognostic value of PD‑L1 expression and CD68 macrophages in tumor nest of patients with primary gastric cancer. (PubMed, Oncol Lett)
However, PD-L1+CD68+ macrophages were strongly related to lower tumor size (diameter <5 cm), early TNM stage (stage I+II), good pathological differentiation and overall survival in TN (P<0.05). In conclusion, PD-L1+CD68+ macrophage infiltration in TN might be a potential indicator of prognosis in patients with primary GC and merits further investigation.
Journal • PD(L)-1 Biomarker • IO biomarker
|
HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • PD-1 (Programmed cell death 1) • CD68 (CD68 Molecule)
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PD-L1 expression • HER-2 expression • CD133 expression
5ms
The role of hypoxia and radiation in developing a CTCs-like phenotype in murine osteosarcoma cells. (PubMed, Front Cell Dev Biol)
These insights offer a comprehensive understanding of the interactions between radiation, hypoxia, and cellular responses in the context of cancer treatment. This study elucidates the complex interplay among radiation, hypoxia, and cellular responses, offering valuable insights into the intricacies and potential advancements in cancer treatment.
Preclinical • Journal
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NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2)
|
CD133 expression
5ms
Circular RNA ZNF800 (hsa_circ_0082096) regulates cancer stem cell properties and tumor growth in colorectal cancer. (PubMed, BMC Cancer)
CircZNF800 is an oncogenic factor that regulate cancer stem cell properties to lead colorectal tumorigenesis, and may be used as a predictive marker for tumor progression and the CRISPR Cas13d-circZNF800 knockdown strategy for therapeutic intervention of colorectal cancer.
Journal • Cancer stem
|
ALK (Anaplastic lymphoma kinase) • CD44 (CD44 Molecule) • SOX9 (SRY-Box Transcription Factor 9) • FZD3 (Frizzled Class Receptor 3) • MIR140 (MicroRNA 140)
|
CD44 expression • CD133 expression
5ms
Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis. (PubMed, BMC Cancer)
Contrary to prior assumptions, the G12V NRAS mutant form is sufficient to elicit hepatocarcinogenesis in the mouse. Furthermore, the upregulation of the MAPK cascade was paralleled by the overexpression of DUSP4, DUSP6, and CD133 in vivo and in vitro. Therefore, DUSP4 and DUSP6 might fine-tune the excessive MAPK activation, a mechanism that can potentially be harnessed therapeutically.
Journal
|
NRAS (Neuroblastoma RAS viral oncogene homolog) • DUSP6 (Dual specificity phosphatase 6) • DUSP4 (Dual Specificity Phosphatase 4)
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NRAS mutation • NRAS G12 • CD133 expression • CD133 overexpression • NRAS G12V
6ms
Differential expression of cancer stem cell markers and pro-inflammatory cytokine IL-1β in the oral squamous cell carcinoma and oral submucosal fibrosis. (PubMed, Int J Health Sci (Qassim))
Multivariate regression analysis demonstrated a significant role for CD44 and CD133 positivity in the increase of IL-1β levels. We concluded that concurrent simultaneous changes in CSC biomarkers and IL-1β may help with early detection of OSMF and OSCC conditions.
Journal • Cancer stem
|
CD44 (CD44 Molecule) • IL1B (Interleukin 1, beta)
|
CD44 expression • CD133 expression • CD44 positive
6ms
Design, synthesis and biological evaluation of novel DCLK1 inhibitor containing purine skeleton for the treatment of pancreatic cancer. (PubMed, Eur J Med Chem)
The preliminary mechanism study demonstrated that I-5 not only inhibited SW1990 cell invasion and migration, but also decreased the expression of prominin-1 (CD133) and cluster of differentiation 44 (CD44), which are considered as differentiation markers for SW1990 stem cells. All the results indicated that I-5, a novel DCLK1 inhibitor, shows promise for further investigation in the treatment of pancreatic cancer.
Journal
|
PROM1 (Prominin 1)
|
CD133 expression
6ms
Heterogeneity of cancer stem cell-related marker expression is associated with three-dimensional structures in malignant pleural effusion produced by lung adenocarcinoma. (PubMed, Cytopathology)
Lung adenocarcinoma cells in the pleural effusion show variable expression of cancer stem cell-related markers, some showing a correlation with the size of cell clusters. Their expression level is potentially correlated with cancer treatment effects.
Journal • Cancer stem • Pleural effusion
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NANOG (Nanog Homeobox)
|
CD133 expression
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