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    BIOMARKER:

    CCR4 overexpression

    i
    Other names: CCR4, C-C Motif Chemokine Receptor 4, CC-CKR-4, CMKBR4, K5-5, Chemokine (C-C Motif) Receptor 4, C-C Chemokine Receptor Type 4, C-C CKR-4, ChemR13, CD194, CCR-4, CKR4, Chemokine (C-C) Receptor 4, CD194 Antigen, HGCN:14099
    Entrez ID:
    1233
    Related biomarkers:
    Expression
    over2years
    Development of a Novel Anti-Mouse CCR4 Monoclonal Antibody (CMab-1) by N-Terminal Peptide Immunization. (PubMed, Monoclon Antib Immunodiagn Immunother)
    Anti-CCR4 monoclonal antibody (mAb) mogamulizumab is approved for adult T cell leukemia/lymphoma and cutaneous T cell lymphomas...Kinetic analyses using flow cytometry showed that Ks of CMab-1 for CHO/mCCR4, P388, and J774-1 cells were 4.2 × 10 M, 5.4 × 10 M, and 1.1 × 10 M, respectively. CMab-1 could be a valuable tool for elucidating mCCR4-related biological responses.
    Preclinical • Journal
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    CCR4 (C-C Motif Chemokine Receptor 4) • CCL2 (Chemokine (C-C motif) ligand 2) • CCL22 (C-C Motif Chemokine Ligand 22)
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    CCR4 overexpression
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    Poteligeo (mogamulizumab-kpkc)