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    BIOMARKER:

    CCR4 negative

    i
    Other names: CCR4, C-C Motif Chemokine Receptor 4, CC-CKR-4, CMKBR4, K5-5, Chemokine (C-C Motif) Receptor 4, C-C Chemokine Receptor Type 4, C-C CKR-4, ChemR13, CD194, CCR-4, CKR4, Chemokine (C-C) Receptor 4, CD194 Antigen, HGCN:14099
    Entrez ID:
    1233
    Related biomarkers:
    Expression
    1year
    Integrated analysis of phase 1a and 1b randomized controlled trials; Treg-targeted cancer immunotherapy with the humanized anti-CCR4 antibody, KW-0761, for advanced solid tumors. (PubMed, PLoS One)
    A durable clinical response was noted in some patients, and high lymphocyte levels before treatment initiation may be a biomarker for the efficacy of KW-0761. The synergistic effect of KW-0761 for depleting Tregs and other immunotherapies is expected in the future.
    P1 data • Journal • IO biomarker • Metastases
    |
    CCR4 (C-C Motif Chemokine Receptor 4)
    |
    CCR4 negative
    |
    Poteligeo (mogamulizumab-kpkc)