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    BIOMARKER:

    CCR2 overexpression

    i
    Other names: CCR2, C-C Motif Chemokine Receptor 2, CC-CKR-2, MCP-1-R, CMKBR2, CD192, CKR2, Monocyte Chemoattractant Protein 1 Receptor, Chemokine (C-C Motif) Receptor 2, C-C Chemokine Receptor Type 2, FLJ78302, CCR-2, Monocyte Chemotactic Protein 1 Receptor, MCP-1 Receptor, CD192 Antigen, C-C CKR-2, CCR2A, CCR2B, CKR2A, CKR2B
    Entrez ID:
    729230
    6ms
    An Engineered Nanoplatform with Tropism toward Irradiated Glioblastoma Augments Its Radioimmunotherapy Efficacy. (PubMed, Adv Mater)
    In two murine models with orthotopic GBM tumors, this nanoplatform reinvigorated immunogenic cell death, and augmented the efficacy and specificity of GBM radioimmunotherapy, with reduced occurrence of irAEs. This study suggests a promising radiation-induced tropism strategy for targeted drug delivery, and presents a potent nanoplatform that enhances the efficacy and safety of radio-immunotherapy.
    Journal
    |
    CCL2 (Chemokine (C-C motif) ligand 2) • CCR2 (C-C Motif Chemokine Receptor 2)
    |
    CCR2 overexpression
    10ms
    Chemokine Receptor 2 Targeted PET/CT Imaging Distant Metastases in Pancreatic Ductal Adenocarcinoma. (PubMed, ACS Pharmacol Transl Sci)
    H&E staining, CCR2 staining, and autoradiography also confirmed the expression of CCR2 and the uptake of Ga-DOTA-ECL1i in the metastatic foci in KPC mice. Using our novel CCR2 targeted radiotracer Ga-DOTA-ECL1i and PET/CT, we demonstrated the sensitive and specific detection of CCR2 in the early PDAC metastases in two mouse models, indicating its potential in future clinical translation.
    Journal
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    CCR2 (C-C Motif Chemokine Receptor 2)
    |
    CCR2 overexpression
    over1year
    Transcriptome changes of immune cells across chemotherapy of triple-negative breast cancer (ESMO 2023)
    Conclusions Chemotherapy affects the quantitative and qualitative composition of mononuclear leukocytes and changes their transcriptomic profile towards proinflammatory activation. This study was funded by the Russian Science Foundation (grant #22-75-10128).
    Immune cell
    |
    CD8 (cluster of differentiation 8) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • CD69 (CD69 Molecule) • CCL5 (Chemokine (C-C motif) ligand 5) • S100A9 (S100 Calcium Binding Protein A9) • BAX (BCL2-associated X protein) • CCR7 (Chemokine (C-C motif) receptor 7) • CD14 (CD14 Molecule) • ITGAM (Integrin, alpha M) • FOXP3 (Forkhead Box P3) • IL32 (Interleukin 32) • CCR2 (C-C Motif Chemokine Receptor 2)
    |
    BAX expression • CCR2 overexpression