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    GENE:

    CCNO (Cyclin O)

    i
    Other names: CCNO, Cyclin O, UDG2, FLJ22422, Cyclin U, Cyclin-O, UNG2, CCNU, Cyclin Domain Containing, CILD29
    Associations

    News

    Trials
    over2years
    Characterization of the immuno-oncological transcriptomic landscape of uterine smooth muscle tumors of uncertain malignancy potential (STUMP) according to clinical outcome (EACR 2023)
    Interestingly, none significantly differentially expressed genes were observed when comparing rSTUMP with LMS and nrSTUMP with LM.ConclusionThe here presented data demonstrates the heterogeneity of the immune-related transcriptomic landscape of uterine STUMP based on their clinical behavior. Specifically, nrSTUMP and rSTUMP have been shown to harbor molecular profiles closer to LM and LMS, respectively.These differences could be exploited to pinpoint novel diagnostic/prognostic markers and correctly stratify STUMP according to their malignant potential.
    Clinical data • Clinical • IO biomarker • Immuno-oncology
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    CD8 (cluster of differentiation 8) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • FANCA (FA Complementation Group A) • BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1) • BIRC5 (Baculoviral IAP repeat containing 5) • S100A8 (S100 Calcium Binding Protein A8) • S100A9 (S100 Calcium Binding Protein A9) • SLC7A5 (Solute Carrier Family 7 Member 5) • CCNB1 (Cyclin B1) • CCNO (Cyclin O)
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    nCounter® PanCancer IO 360™ Panel