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GENE:

CCNG1 (Cyclin G1)

News alerts, weekly reports and conference planners

10d

[Retracted] MicroRNA-27a functions as an oncogene in human osteosarcoma by targeting CCNG1. (PubMed, Oncol Lett)

[This retracts the article DOI: 10.3892/ol.2017.7389.].

10 days ago

Journal

MIR27A (MicroRNA 27a) • CCNG1 (Cyclin G1)

14d

Analysis of Clinical Benefit Using DNG64-CAR-V Chimeric Tumor Targeted Amphotropic RNA Vector in CCNG1 Expressing Cancers. (PubMed, Anticancer Res)

A response rate of 50% and a CBR of 90% for all groups meet the Simon 2-stage threshold of CBR >30%, thereby qualifying all groups for a Phase II study using DNG64-CAR-V+ in CCNG1 expressing advanced cancers.

14 days ago

Journal

CCNG1 (Cyclin G1)

29d

Integrating Gene Expression With Recurrent Mutations Improves Age-Stratified Risk Prediction in Acute Myeloid Leukemia. (PubMed, EJHaem)

Although treatment variables were not included and analysis focused on selected genes, these findings support incorporation of expression-based features into genetic risk models and warrant prospective validation. The authors have confirmed clinical trial registration is not needed for this submission.

29 days ago

Journal

FLT3 (Fms-related tyrosine kinase 3) • NPM1 (Nucleophosmin 1) • RUNX1 (RUNX Family Transcription Factor 1) • ASXL1 (ASXL Transcriptional Regulator 1) • MCL1 (Myeloid cell leukemia 1) • CHEK2 (Checkpoint kinase 2) • CCNG1 (Cyclin G1)

TP53 mutation • NPM1 mutation

Kupffer Cell-Derived Interleukin-6 Aggravates Radiation-Induced Liver Disease by Activating Hepatocyte STAT3 to Promote Ccng1 Transcription. (PubMed, Adv Radiat Oncol)

CCNG1 protein may promote TP53 degradation. When TP53 is downregulated, hepatocyte apoptosis increases significantly, resulting in atypical RILD.

1 month ago

Journal

TP53 (Tumor protein P53) • IL6 (Interleukin 6) • STAT3 (Signal Transducer And Activator Of Transcription 3) • CCNG1 (Cyclin G1)

2ms

Snail1 Induced Suppression of Proliferation via EGR1, FOXO1, and CEPBγ Creates a Vulnerability for Targeting Apoptotic and Cellular Senescence Pathways. (PubMed, Cancers (Basel))

We identified three new major downstream targets of Snail1 that improve our understanding of the role of EMT in limiting stress signaling, apoptosis, and senescence during cell cycle suppression to create a vulnerability for therapeutic targeting.

2 months ago

Journal

CASP3 (Caspase 3) • CCNB2 (Cyclin B2) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • SNAI1 (Snail Family Transcriptional Repressor 1) • EGR1 (Early Growth Response 1) • SOD3 (Superoxide dismutase 3) • CCNG1 (Cyclin G1)

7ms

RNA m5C Modifications in the Development and Prognosis of Muscle-Invasive Bladder Cancer. (PubMed, Mol Carcinog)

This approach yielded an optimized 11-gene prognostic signature comprising GGA1, NUMBL, ECHDC2, NLRC5, EIF2D, GJA1, XPC, DAZAP2, C6orf120, WDR45, and CES1, which demonstrated superior predictive performance in TCGA MIBC patients. These findings establish m5C RNA modification patterns as promising molecular signatures for MIBC prognosis and potential therapeutic targets.

7 months ago

Journal

PTEN (Phosphatase and tensin homolog) • SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1) • FADD (Fas associated via death domain) • MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • BMI1 (BMI1 proto-oncogene, polycomb ring finger) • NLRC5 (NLR Family CARD Domain Containing 5) • XPC (XPC Complex Subunit, DNA Damage Recognition And Repair Factor) • FOXO3 (Forkhead box O3) • GJA1 (Gap Junction Protein Alpha 1) • PAK2 (P21 (RAC1) Activated Kinase 2) • CCNG1 (Cyclin G1) • NUMBL (NUMB Like Endocytic Adaptor Protein)

9ms

Detection of LUAD-Associated Genes Using Wasserstein Distance in Multiomics Feature Selection. (PubMed, Bioengineering (Basel))

These results highlight the complexity of multiomics integration and the need for advanced feature selection techniques to uncover biologically meaningful patterns. Our multiomics strategy and robust selection approach provide insights into the genetic determinants of TMB, offering potential biomarkers for targeted LUAD therapies and demonstrating the power of Wasserstein distance-based feature selection in complex genomic analysis.

9 months ago

Journal • Tumor mutational burden • IO biomarker

TMB (Tumor Mutational Burden) • STING (stimulator of interferon response cGAMP interactor 1) • REEP5 (Receptor Accessory Protein 5) • CCNG1 (Cyclin G1)

10ms

p21, ccng1, foxo3b, and fbxw7 contribute to p53-dependent cell cycle arrest. (PubMed, iScience)

Our analysis also stresses the importance of ortholog to paralog analysis across species, since in many cases the paralog but not ortholog in differing species is p53 dependent. Using a CRISPR-Cas9 G0 "crispant" screen in mdm2, puma, noxa, and p21 quadruple knockout zebrafish, we identified ccng1, fbxw7, and foxo3b that are involved in p53-dependent cell-cycle arrest.

10 months ago

Journal

FBXW7 (F-Box And WD Repeat Domain Containing 7) • PMAIP1 (Phorbol-12-Myristate-13-Acetate-Induced Protein 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • BBC3 (BCL2 Binding Component 3) • CCNG1 (Cyclin G1)

1year

Transcriptomic analysis of the anti-tumor effects of leflunomide in prolactinoma. (PubMed, Sci Rep)

Hence, the anti-proliferative effects of leflunomide on prolactinoma cell lines may be mediated through programmed cell death pathways. Importantly, combining cabergoline with leflunomide effectively enhances the toxic effect of cabergoline, suggesting a potential therapeutic role for leflunomide in drug-resistant prolactinoma.

1 year ago

Journal

CDKN1A (Cyclin-dependent kinase inhibitor 1A) • PLK2 (Polo Like Kinase 2) • CCNG1 (Cyclin G1)

leflunomide

1year

GCBRGCN: Integration of ceRNA and RGCN to Identify Gastric Cancer Biomarkers. (PubMed, Bioengineering (Basel))

Moreover, FOXC1 and LINC00324 were characterized as biomarkers with significance in both prognosis and diagnosis. Our work offers a novel framework for GC biomarker identification, highlighting the critical role of multiple types RNA interaction in oncological research.

1 year ago

Journal

FOXC1 (Forkhead Box C1) • CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) • CCNG1 (Cyclin G1) • CITED2 (Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 2)

1year

miRNA-503 inhibition exerts anticancer effects and reduces tumor growth in mesothelioma. (PubMed, J Exp Clin Cancer Res)

Our study is the first reporting an oncomiR role for miR-503 in MM and suggests that its inactivation could have a clinical value in MM patients. This study reveals that miRNA-503 acts as an oncomiR in MM suggesting that its inhibition, through LNP delivery, has the potential to be considered as a novel therapeutic strategy in MM.

1 year ago

Journal

CXCL8 (Chemokine (C-X-C motif) ligand 8) • SPP1 (Secreted Phosphoprotein 1) • TIMP2 (TIMP Metallopeptidase Inhibitor 2) • SERPINE1 (Serpin Family E Member 1) • MIR503 (MicroRNA 503) • S1PR1 (Sphingosine-1-Phosphate Receptor 1) • CCNG1 (Cyclin G1)

cisplatin

over1year

Four functional genotoxic marker genes (Bax, Btg2, Ccng1, and Cdkn1a) discriminate genotoxic hepatocarcinogens from non-genotoxic hepatocarcinogens and non-genotoxic non-hepatocarcinogens in rat public toxicogenomics data, Open TG-GATEs. (PubMed, Genes Environ)

The present results unequivocally demonstrate the availability of four genotoxic marker genes ((Bax, Btg2, Ccng1, and Cdkn1a) and PCA in discriminating GTHCs from NGTHCs and NGTNHCs in Open TG-GATEs. These findings strongly support our recommendation that future rat liver in vivo toxicogenomics tests prioritize these four genotoxic marker genes, as they have proven to be highly effective in discriminating between different types of hepatocarcinogens.

over 1 year ago

Preclinical • Journal

GDF15 (Growth differentiation factor 15) • BAX (BCL2-associated X protein) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • LRP1 (LDL Receptor Related Protein 1) • PLK2 (Polo Like Kinase 2) • BTG2 (BTG Anti-Proliferation Factor 2) • CCNF (Cyclin F) • CCNG1 (Cyclin G1)

dexamethasone • aspirin