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    BIOMARKER:

    CCND2 mutation

    i
    Other names: CCND2, Cyclin D2
    Entrez ID:
    894
    Related biomarkers:
    Expression
    Others
    7ms
    Genomic and immune profiling of breast cancer brain metastases (SABCS 2023)
    This analysis showed moderate discrepancy in subtype call of BrM by tissue preparation (frozen vs. FFPE), with LumB classification showing the highest discrepancy, and more commonly called in FFPE tissues. Subtype concordance between ECT and BrM was relatively high.
    BRCA Biomarker
    |
    EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • BRAF (B-raf proto-oncogene) • ER (Estrogen receptor) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • BRCA2 (Breast cancer 2, early onset) • PTEN (Phosphatase and tensin homolog) • ATM (ATM serine/threonine kinase) • ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3) • RB1 (RB Transcriptional Corepressor 1) • NOTCH1 (Notch 1) • NF1 (Neurofibromin 1) • IFNG (Interferon, gamma) • CDK4 (Cyclin-dependent kinase 4) • FBXW7 (F-Box And WD Repeat Domain Containing 7) • CD4 (CD4 Molecule) • CCND2 (Cyclin D2) • TGFB1 (Transforming Growth Factor Beta 1)
    |
    BRAF mutation • ATM mutation • PTEN mutation • ERBB3 mutation • CCND2 mutation
    |
    Prosigna™ Breast Cancer Prognostic Gene Signature Assay
    10ms
    CCND2 mutations in atypical chronic myeloid leukemia: a report of two cases. (PubMed, Leuk Lymphoma)
    CCND2 mutations have not been frequently detected in MPN or MDS/MPN patients. We describe two cases of aCML with two CCND2 mutations in 280 and 281 codons which rapidly develop progressive characteristics, and we reviewed the literature about this unfavorable association, suggesting a role as a new possible marker of aggressive disease.
    Journal
    |
    ABL1 (ABL proto-oncogene 1) • SETBP1 (SET Binding Protein 1) • CCND2 (Cyclin D2) • ETNK1 (Ethanolamine Kinase 1)
    |
    CCND2 mutation • ETNK1 mutation