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    BIOMARKER:

    CCNB2 expression

    i
    Other names: CCNB2, Cyclin B2, G2/Mitotic-Specific Cyclin-B2
    Entrez ID:
    9133
    Related biomarkers:
    Expression
    3ms
    Prognostic value of cyclin B1 and cyclin B2 expression in breast cancer: A systematic review and updated meta-analysis. (PubMed, Medicine (Baltimore))
    This meta-analysis provides evidence supporting the prognostic significance of cyclin B1 and B2 expression in breast cancer. High expression of cyclin B1 and B2 is associated with worse survival, indicating their potential as prognostic markers in breast cancer.
    Retrospective data • Review • Journal
    |
    CCNB2 (Cyclin B2) • CCNB1 (Cyclin B1)
    |
    CCNB2 expression
    11ms
    PER2 integrates circadian disruption and pituitary tumorigenesis. (PubMed, Theranostics)
    PER2 integrates circadian disruption and pituitary tumorigenesis. These findings advance our understanding of crosstalk between circadian clock and pituitary adenomas and highlight the relevance of clock-based approaches in disease management.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • PER2 (Period Circadian Regulator 2) • CCNB2 (Cyclin B2) • CDC20 (Cell Division Cycle 20)
    |
    CCNB2 expression
    over1year
    Six Cell Cycle-related Genes Serve as Potential Prognostic Biomarkers and Correlated with Immune Infiltrates in Hepatocellular Carcinoma. (PubMed, J Cancer)
    In addition, CDK1, CDC20, CCNA2, CCNB1 and CCNB2 expressions may be involved in the regulation of monocytes and tumor-associated macrophages (TAMs) in HCC, respectively. These findings strongly suggested that cell cycle-related genes could be used as novel biomarkers for exploring the prognosis and immune cells infiltration of HCC.
    Journal
    |
    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • CCNA2 (Cyclin A2) • CCNB2 (Cyclin B2) • CDC20 (Cell Division Cycle 20) • CDK1 (Cyclin-dependent kinase 1) • CCNB1 (Cyclin B1)
    |
    CCNB2 expression
    over1year
    CCNB2 expression correlates with worse outcomes in breast cancer patients: a pooled analysis. (PubMed, Women Health)
    High expression of CCNB2 in BC is associated with worse OS, RFS, and DMFS, but not with DSS and DFS. More well-designed studies from different populations and different BC types are still needed.
    Retrospective data • Journal
    |
    CCNB2 (Cyclin B2)
    |
    CCNB2 expression
    over1year
    Upregulation of CCNB2 and Its Perspective Mechanisms in Cerebral Ischemic Stroke and All Subtypes of Lung Cancer: A Comprehensive Study. (PubMed, Front Integr Neurosci)
    Concurrently, the expression of CCNB2 distributed similarly to TOP2A as a module marker of cell proliferation in cell cluster. These findings can help in the field of the pathogenesis of LC-related CIS and neuron repair after CIS damage.
    Journal
    |
    TOP2A (DNA topoisomerase 2-alpha) • CCNB2 (Cyclin B2)
    |
    CCNB2 expression • TOP2A expression
    almost2years
    Hsa_circ_0000285 knockdown inhibits the progression of hepatocellular carcinoma by sponging miR-582-3p to regulate CCNB2 expression. (PubMed, Hum Exp Toxicol)
    Our study has demonstrated that hsa_circ_0000285 fosters the development of malignant HCC cells phenotypes through the modulation of the miR-582-3p/CCNB2 axis. Thus, these results suggest that hsa_circ_0000285 is a prospective target for HCC treatment.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CCNB2 (Cyclin B2) • MIR582 (MicroRNA 582)
    |
    BCL2 expression • BAX expression • CCNB2 expression
    2years
    CCNB2 is a novel prognostic factor and a potential therapeutic target in Low-grade glioma (LGG). (PubMed, Biosci Rep)
    CCNB2 may be used as a potential biomarker to determine the prognosis of LGG and is also related to immune infiltration.
    Journal
    |
    CCNB2 (Cyclin B2)
    |
    CCNB2 expression
    2years
    CRHBP is degraded via autophagy and exerts anti-hepatocellular carcinoma effects by reducing cyclin B2 expression and dissociating cyclin B2-CDK1 complex. (PubMed, Cancer Gene Ther)
    Blocking autophagy with 3-MA, chloroquine or siSQSTM1 prevented CRHBP degradation in HCC cells. Collectively, our study uncovers a role for CRHBP in retarding HCC development, reducing cyclin B2 expression and impairing cyclin B2-CDK1 interaction. CRHBP downregulation in HCC may attribute to p62-mediated autophagy.
    Journal
    |
    SQSTM1 (Sequestosome 1) • CCNB2 (Cyclin B2) • CDK1 (Cyclin-dependent kinase 1)
    |
    CCNB2 expression
    |
    chloroquine phosphate
    over2years
    Prognostic Significance of CCNB2 Expression in Triple-Negative Breast Cancer. (PubMed, Cancer Manag Res)
    Overall survival of patients was significantly correlated with the expression of CCNB2 (p < 0.05). CCNB2 may play a crucial role in the development of TNBC and has the potential to be used as a prognostic biomarker for TNBC.
    Journal
    |
    CCNB2 (Cyclin B2)
    |
    CCNB2 expression
    over2years
    Bioinformatics prediction and experimental verification identify MAD2L1 and CCNB2 as diagnostic biomarkers of rhabdomyosarcoma. (PubMed, Cancer Cell Int)
    The expression levels of MAD2L1 and CCNB2 are potential indicators of TME status changes in RMS, which may help guide the prognosis of patients with RMS and the clinical staging of tumours.
    Journal
    |
    CCNB2 (Cyclin B2)
    |
    CCNB2 expression