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    BIOMARKER:

    CCL8 elevation

    i
    Other names: CCL8, C-C Motif Chemokine Ligand 8, MCP-2, HC14, SCYA8, Small Inducible Cytokine Subfamily A (Cys-Cys), Member 8 (Monocyte Chemotactic Protein 2), Monocyte Chemoattractant Protein 2, Chemokine (C-C Motif) Ligand 8, Monocyte Chemotactic Protein 2, Small-Inducible Cytokine A8, C-C Motif Chemokine 8, SCYA10, MCP2
    Entrez ID:
    6355
    Related biomarkers:
    Others
    9ms
    Single-cell RNA sequencing reveals recruitment of the M2-like CCL8high macrophages in Lewis lung carcinoma-bearing mice following hypofractionated radiotherapy. (PubMed, J Transl Med)
    Hypofractionated radiotherapy enhances the infiltration of CCL8high macrophages and amplifies their roles in macrophage recruitment through the CCL signaling pathway, leading to an immunosuppressive tumor microenvironment. These findings highlight the potential of targeting TAMs and introduces a novel combination to improve the efficacy of hypofractionated radiotherapy.
    Preclinical • Journal
    |
    CCL2 (Chemokine (C-C motif) ligand 2) • CCL8 (C-C Motif Chemokine Ligand 8) • MRC1 (Mannose Receptor C-Type 1)
    |
    CCL8 elevation
    over2years
    CCL8 as a promising prognostic factor in diffuse large B-cell lymphoma via M2 macrophage interactions: A bioinformatic analysis of the tumor microenvironment. (PubMed, Front Immunol)
    Importantly, a series of bioinformatics analysis indicated that CCL8 might become an effective target for DLBCL, which interacts with M2 macrophage and immune checkpoint. The potential related mechanisms need to be further elucidated.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • CD163 (CD163 Molecule) • CCL8 (C-C Motif Chemokine Ligand 8)
    |
    CTLA4 expression • CCL8 elevation