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    BIOMARKER:

    CCL27 overexpression

    i
    Other names: CCL27, C-C Motif Chemokine Ligand 27, CC Chemokine ILC, Skinkine, CTACK, ILC, Small Inducible Cytokine Subfamily A (Cys-Cys), Member 27, Cutaneous T-Cell Attracting Chemokine, Chemokine (C-C Motif) Ligand 27, IL-11 R-Alpha-Locus Chemokine, IL-11 Ralpha-Locus Chemokine, Small-Inducible Cytokine A27, C-C Motif Chemokine 27, SCYA27, ESkine, PESKY, CTAK, ALP, Cutaneous T-Cell-Attracting Chemokine, ESKINE
    Entrez ID:
    10850
    24d
    Genetically predicted serum ferritin mediates the association between inflammatory cytokines and non-alcoholic fatty liver disease. (PubMed, Front Endocrinol (Lausanne))
    In conclusion, our study identified a causal relationship between inflammatory cytokines and NAFLD, with a small proportion of the effect mediated by ferritin, but a majority of the effect of inflammatory cytokines on NAFLD remains unclear. Further research is needed on additional risk factors as potential mediators.
    Journal
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    IL2 (Interleukin 2) • MIF (Macrophage Migration Inhibitory Factor) • CCL11 (C-C Motif Chemokine Ligand 11) • CCL27 (C-C Motif Chemokine Ligand 27) • IL16 (Interleukin 16)
    |
    CCL27 overexpression
    over2years
    Genetically Predicted Circulating Levels of Cytokines and the Risk of Cancer. (PubMed, Front Immunol)
    By using a genetic epidemiological approach, our study systematically evaluated the role of circulating cytokines on the risk of cancer, and provided clues for potential therapeutic targets. However, the exact underlying biological mechanism warrants further investigation.
    Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha) • IL18 (Interleukin 18) • IL17A (Interleukin 17A) • CCL27 (C-C Motif Chemokine Ligand 27)
    |
    CCL27 overexpression
    almost3years
    Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis. (PubMed, BMC Med)
    Our study adds to current knowledge on the role of specific inflammatory biomarker pathways in cancer aetiology. Further validation is needed to assess the potential of these cytokines as pharmacological or lifestyle targets for cancer prevention.
    Journal
    |
    CXCL9 (Chemokine (C-X-C motif) ligand 9) • MIF (Macrophage Migration Inhibitory Factor) • IL18 (Interleukin 18) • CCL27 (C-C Motif Chemokine Ligand 27)
    |
    CCL27 overexpression
    over3years
    CCL27 Signaling in the Tumor Microenvironment. (PubMed, Adv Exp Med Biol)
    Moreover, several studies have shown an association between CCL27 expression and a variety of neoplasms including skin cancer.In this chapter, we address the role of chemokine CCL27 in the tumor microenvironment in the most relevant cancers of the skin and other anatomical locations. We also make a brief comment on future perspectives and the potential relation of CCL27 with different immunotherapeutic modalities.
    Journal • IO biomarker
    |
    CCL27 (C-C Motif Chemokine Ligand 27)
    |
    CCL27 overexpression