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    BIOMARKER:

    CCL19 elevation

    i
    Other names: CCL19, C-C Motif Chemokine Ligand 19, ELC, CK Beta-11, Exodus-3, MIP-3b, SCYA19, CKb11, Small Inducible Cytokine Subfamily A (Cys-Cys), Member 19, Epstein-Barr Virus-Induced Molecule 1 Ligand Chemokine, Macrophage Inflammatory Protein 3-Beta, Chemokine (C-C Motif) Ligand 19, Small-Inducible Cytokine A19, Beta Chemokine Exodus-3, CC Chemokine Ligand 19, C-C Motif Chemokine 19, EBI1-Ligand Chemokine, MIP-3-Beta, MIP3B, Macrophage Inflammatory Protein 3 Beta, Beta-Chemokine Exodus-3, EBI1 Ligand Chemokine
    Entrez ID:
    6363
    Related biomarkers:
    Expression
    6ms
    CCL19: a novel prognostic chemokine modulates the tumor immune microenvironment and outcomes of cancers. (PubMed, Aging (Albany NY))
    In conclusion, our findings support the notion that elevated CCL19 expression is linked to favorable outcomes and enhanced anti-tumor immunity, characterized by increased CD8 T cells within the TME. This suggests the potential of CCL19 as a prognostic marker, predictive biomarker for immunotherapy, therapeutic target of cancers.
    Journal • IO biomarker
    |
    CD8 (cluster of differentiation 8) • CCL19 (C-C Motif Chemokine Ligand 19)
    |
    CCL19 elevation • CCL19 underexpression
    over2years
    Combination of IDO1 and CCL19 expression in the tumor tissue reduces survival in HPV positive cervical cancer. (PubMed, J Reprod Immunol)
    Although we could not identify IDO1 as an independent prognostic factor, we found that high levels of IDO1 expression may further reduce survival outcomes in patients with low CCL19 expression. This could be vital for designing immuno therapeutic interventions targeting IDO1.
    Journal • IO biomarker
    |
    CXCR4 (Chemokine (C-X-C motif) receptor 4) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • CCR4 (C-C Motif Chemokine Receptor 4) • IDO1 (Indoleamine 2,3-dioxygenase 1) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • CCL19 (C-C Motif Chemokine Ligand 19) • CCR7 (Chemokine (C-C motif) receptor 7) • CCL2 (Chemokine (C-C motif) ligand 2) • CCL22 (C-C Motif Chemokine Ligand 22) • CXCR3 (C-X-C Motif Chemokine Receptor 3)
    |
    IDO1 expression • CCL19 elevation