^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    CCL11 overexpression

    i
    Other names: CCL11, C-C Motif Chemokine Ligand 11, Small Inducible Cytokine Subfamily A (Cys-Cys), Member 11 (Eotaxin), Chemokine (C-C Motif) Ligand 11, Eosinophil Chemotactic Protein, Eotaxin-1, Eotaxin, SCYA11, Small-Inducible Cytokine A11, C-C Motif Chemokine 11
    Entrez ID:
    6356
    Related biomarkers:
    Others
    3ms
    Exploring CCL11 in breast cancer: unraveling its anticancer potential and immune modulatory effects involving the Akt-S6 signaling. (PubMed, J Cancer Res Clin Oncol)
    CCL11 expression correlates with immune cell infiltration in breast cancer, indicating its potential as a prognostic biomarker for BRCA.
    Journal • BRCA Biomarker
    |
    BRCA (Breast cancer early onset) • CCL11 (C-C Motif Chemokine Ligand 11)
    |
    CCL11 overexpression
    over3years
    Myeloid-derived suppressor cells promote lung cancer metastasis by CCL11 to activate ERK and AKT signaling and induce epithelial-mesenchymal transition in tumor cells. (PubMed, Oncogene)
    Moreover, high expression of CCL11 was associated with a poor prognosis in lung cancer as well as other types of cancer. Our findings underscore that MDSCs produce CCL11 to promote NSCLC metastasis via activation of ERK and AKT signaling and induction of EMT, suggesting that the MDSCs-CCL11-ERK/AKT-EMT axis contains potential targets for NSCLC metastasis treatment.
    Journal
    |
    CCL11 (C-C Motif Chemokine Ligand 11)
    |
    CCL11 overexpression