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BIOMARKER:

CCAT2 overexpression

i
Other names: CCAT2, Colon Cancer Associated Transcript 2, LINC00873, NCCP1, Colon Cancer Associated Transcript 2 (Non-Protein Coding), Non-Coding RNA Involved In Cancer Predisposition 1, Long Intergenic Non-Protein Coding RNA 873, HSALNG0068443, CCAT2
Entrez ID:
4ms
lncRNA CCAT2 Protects Against Cardiomyocyte Injury After Myocardial Ischemia/Reperfusion by Regulating BMI1 Expression. (PubMed, Int Heart J)
In addition, miR-539-3p overexpression reversed the protective effects of CCAT2. Furthermore, CCAT2 activated the Wnt/β-catenin pathway under the H/R condition via the miR-539-3p/BMI1 axis.Overall, this investigation showed the protective effects of the CCAT2/miR-539-3p/BMI1/Wnt/β-catenin regulatory axis against cardiomyocyte injury induced by H/R.
Journal
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BMI1 (BMI1 proto-oncogene, polycomb ring finger) • CCAT2 (Colon Cancer Associated Transcript 2)
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CCAT2 overexpression • BMI1 expression
6ms
Tectorigenin Inhibits Glycolysis-induced Cell Growth and Proliferation by Modulating LncRNA CCAT2/miR-145 Pathway in Colorectal Cancer. (PubMed, Curr Cancer Drug Targets)
Tec can inhibit the proliferation and glycolysis of CRC cells through the lncRNA CCAT2/miR-145 axis. Altogether, the potential targets discovered in this research are of great significance for CRC treatment and new drug development.
Journal
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CCAT2 (Colon Cancer Associated Transcript 2) • MIR145 (MicroRNA 145)
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CCAT2 overexpression
1year
LncRNA CCAT2 promotes malignant progression of metastatic gastric cancer through regulating CD44 alternative splicing. (PubMed, Cell Oncol (Dordr))
Our findings identified a novel mechanism by which lncRNA CCAT2, as a type of protein-binding RNA, regulates alternative splicing of CD44 and promotes GC progression. This axis may become an effective target for clinical diagnosis and treatment.
Journal • Metastases
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CD44 (CD44 Molecule) • CCAT2 (Colon Cancer Associated Transcript 2) • ESRP1 (Epithelial Splicing Regulatory Protein 1)
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CD44 expression • CCAT2 overexpression
over1year
Dual Function of CCAT2 in Regulating Luminal Subtype of Breast Cancer Depending on the Subcellular Distribution. (PubMed, Cancers (Basel))
In conclusion, the current study, for the first time, revealed a dual function of lncRNA CCAT2 as a tumor suppressor or oncogene depending upon its subcellular distribution. It also demonstrated the regulatory mechanism of cytoplasmic CCAT2 in suppressing tumorigenesis in the luminal subtype of breast cancer.
Journal
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KLF4 (Kruppel-like factor 4) • SOX2 • POU5F1 (POU Class 5 Homeobox 1) • CCAT2 (Colon Cancer Associated Transcript 2) • MIR221 (MicroRNA 221) • NANOG (Nanog Homeobox)
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CCAT2 overexpression
over1year
CCAT2 knockdown inhibits cell growth, and migration and promotes apoptosis through regulating the hsa-mir-145-5p/AKT3/mTOR axis in tamoxifen-resistant MCF7 cells. (PubMed, Life Sci)
CCAT2 regulates cell cycle, migration, and apoptosis in MCF7-R via the hsa-miR-145-5p/AKT3/mTOR axis. Therefore, CCAT2 may be a target to enhance the sensitivity of resistant MCF7 cells to TAM.
Journal • IO biomarker
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ER (Estrogen receptor) • BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CCAT2 (Colon Cancer Associated Transcript 2) • MIR145 (MicroRNA 145)
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ER positive • BCL2 expression • BAX expression • CCAT2 overexpression
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tamoxifen
almost2years
Long non-coding RNA colon cancer-associated transcript 2: role and function in human cancers. (PubMed, Chin Med J (Engl))
This article reviews the biological functions of CCAT2 and its mechanisms of action in tumors from previous studies. In this review, we attempt to provide a molecular basis for future clinical applications of lncRNA CCAT2.
Journal
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CCAT2 (Colon Cancer Associated Transcript 2)
|
CCAT2 overexpression
almost2years
Effect of long noncoding RNA CCAT2 on drug sensitivity to 5-fluorouracil of breast cancer cells through microRNA-145 meditated by p53. (PubMed, J Biochem Mol Toxicol)
Upregulation of miR-145 induced by silencing of CCAT2 can be invalidated by p53-siRNA. To conclude, p53-induced activation of miR-145 could be inhibited by CCAT2, while overexpression of CCAT2 could improve the drug resistance of BC cells to 5-Fu.
Journal
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ER (Estrogen receptor) • PGR (Progesterone receptor) • CCAT2 (Colon Cancer Associated Transcript 2) • MIR145 (MicroRNA 145)
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TP53 expression • CCAT2 overexpression
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5-fluorouracil
over2years
Long noncoding RNA CCAT2 reduces chemosensitivity to 5-fluorouracil in breast cancer cells by activating the mTOR axis. (PubMed, J Cell Mol Med)
Breast cancer (BC) is the most prevalent cancer in women and the second leading cause for cancer-related death in women. After si-CCAT2 or CCI-779 treatment, the growth rate of transplanted tumours was inhibited, while promoted after CCAT2 overexpression. CCAT2 may reduce BC cell chemosensitivity to 5-Fu by activating the mTOR pathway.
Journal
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CCAT2 (Colon Cancer Associated Transcript 2)
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CCAT2 overexpression
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5-fluorouracil • Torisel (temsirolimus)
over2years
Serum CCAT2 as a biomarker for adjuvant diagnosis and prognostic prediction of cervical cancer. (PubMed, J Ovarian Res)
Our study indicates that CCAT2 may be valuable in complementary diagnosis and monitoring of progression and prognosis of CC patients. Combined detection of CCAT2, CA125 and SCC can greatly improve the diagnostic efficiency of primary CC.
Journal
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CCAT2 (Colon Cancer Associated Transcript 2)
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CCAT2 overexpression