In addition, miR-539-3p overexpression reversed the protective effects of CCAT2. Furthermore, CCAT2 activated the Wnt/β-catenin pathway under the H/R condition via the miR-539-3p/BMI1 axis.Overall, this investigation showed the protective effects of the CCAT2/miR-539-3p/BMI1/Wnt/β-catenin regulatory axis against cardiomyocyte injury induced by H/R.
20 days ago
Journal
|
BMI1 (BMI1 proto-oncogene, polycomb ring finger) • CCAT2 (Colon Cancer Associated Transcript 2)
Tec can inhibit the proliferation and glycolysis of CRC cells through the lncRNA CCAT2/miR-145 axis. Altogether, the potential targets discovered in this research are of great significance for CRC treatment and new drug development.
3 months ago
Journal
|
CCAT2 (Colon Cancer Associated Transcript 2) • MIR145 (MicroRNA 145)
Our findings identified a novel mechanism by which lncRNA CCAT2, as a type of protein-binding RNA, regulates alternative splicing of CD44 and promotes GC progression. This axis may become an effective target for clinical diagnosis and treatment.
10 months ago
Journal • Metastases
|
CD44 (CD44 Molecule) • CCAT2 (Colon Cancer Associated Transcript 2) • ESRP1 (Epithelial Splicing Regulatory Protein 1)
In conclusion, the current study, for the first time, revealed a dual function of lncRNA CCAT2 as a tumor suppressor or oncogene depending upon its subcellular distribution. It also demonstrated the regulatory mechanism of cytoplasmic CCAT2 in suppressing tumorigenesis in the luminal subtype of breast cancer.
CCAT2 regulates cell cycle, migration, and apoptosis in MCF7-R via the hsa-miR-145-5p/AKT3/mTOR axis. Therefore, CCAT2 may be a target to enhance the sensitivity of resistant MCF7 cells to TAM.
over 1 year ago
Journal • IO biomarker
|
ER (Estrogen receptor) • BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CCAT2 (Colon Cancer Associated Transcript 2) • MIR145 (MicroRNA 145)
This article reviews the biological functions of CCAT2 and its mechanisms of action in tumors from previous studies. In this review, we attempt to provide a molecular basis for future clinical applications of lncRNA CCAT2.
Upregulation of miR-145 induced by silencing of CCAT2 can be invalidated by p53-siRNA. To conclude, p53-induced activation of miR-145 could be inhibited by CCAT2, while overexpression of CCAT2 could improve the drug resistance of BC cells to 5-Fu.
over 1 year ago
Journal
|
ER (Estrogen receptor) • PGR (Progesterone receptor) • CCAT2 (Colon Cancer Associated Transcript 2) • MIR145 (MicroRNA 145)
Breast cancer (BC) is the most prevalent cancer in women and the second leading cause for cancer-related death in women. After si-CCAT2 or CCI-779 treatment, the growth rate of transplanted tumours was inhibited, while promoted after CCAT2 overexpression. CCAT2 may reduce BC cell chemosensitivity to 5-Fu by activating the mTOR pathway.
Our study indicates that CCAT2 may be valuable in complementary diagnosis and monitoring of progression and prognosis of CC patients. Combined detection of CCAT2, CA125 and SCC can greatly improve the diagnostic efficiency of primary CC.