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DRUG:

anzurstobart (BMS-986351)

i
Other names: BMS-986351, CC 95251, CC-95251
Company:
BMS
Drug class:
SIRPA antagonist
2ms
Trial termination • Combination therapy • Metastases
|
CD20 (Membrane Spanning 4-Domains A1)
|
CD20 positive
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Erbitux (cetuximab) • Rituxan (rituximab) • anzurstobart (BMS-986351)
2ms
A Study to Assess the Effect of CC-95251 in Participants With Acute Myeloid Leukemia and Myelodysplastic Syndromes (clinicaltrials.gov)
P1, N=56, Completed, Bristol-Myers Squibb | Active, not recruiting --> Completed | N=218 --> 56 | Trial completion date: Jun 2026 --> Jul 2024 | Trial primary completion date: Jun 2026 --> Jul 2024
Trial completion • Enrollment change • Trial completion date • Trial primary completion date • Combination therapy
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Venclexta (venetoclax) • azacitidine • anzurstobart (BMS-986351)
8ms
A Study to Assess the Effect of CC-95251 in Participants With Acute Myeloid Leukemia and Myelodysplastic Syndromes (clinicaltrials.gov)
P1, N=218, Active, not recruiting, Bristol-Myers Squibb | Recruiting --> Active, not recruiting
Enrollment closed
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Venclexta (venetoclax) • azacitidine • anzurstobart (BMS-986351)
10ms
Discovery and Preclinical Activity of BMS-986351, an Antibody to SIRPα that Enhances Macrophage-Mediated Tumor Phagocytosis when Combined with Opsonizing Antibodies. (PubMed, Cancer Res Commun)
In vitro, BMS-986351 increased phagocytic activity against cell lines from solid tumors and hematological malignancies, and this effect was markedly enhanced when BMS-986351 was combined with the opsonizing antibodies cetuximab and rituximab. A phase I dose escalation/ expansion study of BMS-986351 for the treatment of advanced solid and hematologic malignancies is underway (NCT03783403).
Preclinical • Journal
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CD47 (CD47 Molecule) • SIRPA (Signal Regulatory Protein Alpha)
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CD47 overexpression • CD47 expression
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Erbitux (cetuximab) • Rituxan (rituximab) • anzurstobart (BMS-986351)
12ms
Trial completion date • Combination therapy • Metastases
|
CD20 (Membrane Spanning 4-Domains A1)
|
CD20 positive
|
Erbitux (cetuximab) • Rituxan (rituximab) • anzurstobart (BMS-986351)
over1year
Enrollment closed • Combination therapy • Metastases
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CD20 (Membrane Spanning 4-Domains A1)
|
CD20 positive
|
Erbitux (cetuximab) • Rituxan (rituximab) • anzurstobart (BMS-986351)
over2years
FIRST CLINICAL STUDY OF THE ANTI-SIGNAL REGULATORY PROTEIN-ALPHA (SIRPΑ) ANTIBODY CC-95251 COMBINED WITH RITUXIMAB IN PATIENTS WITH RELAPSED/REFRACTORY (R/R) NON-HODGKIN LYMPHOMA (NHL) (EHA 2022)
Conclusion CC-95251 + ritux demonstrated a manageable safety profile and promising efficacy in pts with heavily pretreated CD20+ R/R NHL. The study is currently enrolling in the dose-expansion phase.
Clinical
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CD47 (CD47 Molecule) • SIRPA (Signal Regulatory Protein Alpha)
|
Rituxan (rituximab) • anzurstobart (BMS-986351)
over2years
CC-95251-ST-001: A Study of CC-95251, a Monoclonal Antibody Directed Against SIRPα, in Participants With Advanced Solid and Hematologic Cancers (clinicaltrials.gov)
P1, N=230, Recruiting, Celgene | Trial completion date: Nov 2024 --> Aug 2025 | Trial primary completion date: Nov 2022 --> Jun 2024
Trial completion date • Trial primary completion date • Combination therapy
|
CD20 (Membrane Spanning 4-Domains A1)
|
CD20 positive
|
Erbitux (cetuximab) • Rituxan (rituximab) • anzurstobart (BMS-986351)
3years
Interim Results from the First Clinical Study of CC-95251, an Anti-Signal Regulatory Protein-Alpha (SIRPα) Antibody, in Combination with Rituximab in Patients with Relapsed and/or Refractory Non-Hodgkin Lymphoma (R/R NHL) (ASH 2021)
CC-95251-ST-001 (NCT03783403) is a multicenter, open-label, phase 1, dose-escalation and expansion study of CC-95251 in pts with advanced solid tumors and CD20+ R/R NHL. CC-95251, a novel anti-SIRPα antibody, demonstrated a manageable safety profile and promising efficacy in combination with rituximab in pts with heavily pretreated CD20+ R/R NHL. The study continues to enroll in the dose-expansion phase. Updated safety and efficacy data will be presented.
Clinical • Combination therapy
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CD20 (Membrane Spanning 4-Domains A1) • CD47 (CD47 Molecule) • SIRPA (Signal Regulatory Protein Alpha)
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Rituxan (rituximab) • anzurstobart (BMS-986351) • fenretinide nanoparticle (ST-001 nanoFenretinide)
3years
Discovery and Preclinical Characterization of CC-95251, an Anti-SIRPα Antibody That Enhances Macrophage-Mediated Phagocytosis of Non-Hodgkin Lymphoma (NHL) Cells When Combined with Rituximab (ASH 2021)
These results support the clinical evaluation of CC-95251 + rituximab for relapsed or refractory NHL. A phase 1 dose-escalation and -expansion study of CC-95251 for the treatment of advanced solid and hematologic malignancies is underway (NCT03783403).
Preclinical
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CD20 (Membrane Spanning 4-Domains A1) • CD47 (CD47 Molecule) • CD163 (CD163 Molecule) • SIRPA (Signal Regulatory Protein Alpha)
|
Rituxan (rituximab) • anzurstobart (BMS-986351)