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    GENE:

    CBX6 (Chromobox 6)

    i
    Other names: CBX6, Chromobox 6, Chromobox Protein Homolog 6, Chromobox Homolog 6
    Associations

    News

    Trials
    2ms
    Identification of breast cancer susceptibility genes via trans-ethnic Mendelian randomization and colocalization analyses. (PubMed, Medicine (Baltimore))
    This integrative genomics and bioinformatics approach identified 7 promising drug targets for breast cancer. These findings offer novel avenues for the development of targeted therapies and underscore the importance of genetic epidemiology in guiding drug discovery.
    Journal
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    LAMC1 (Laminin Subunit Gamma 1) • CBX6 (Chromobox 6)
    3ms
    CBX6 induces CD8+ T cell exhaustion and tumor development in esophageal squamous cell carcinoma through SMARCD1-mediated CCL8 secretion and lactate efflux. (PubMed, Cell Biol Toxicol)
    Tissue microarrays analysis suggested that CBX6 and SMARCD1 were linked to immunosuppression and poor prognosis in clinical samples. In conclusion, this study suggests that CBX6 induces CD8+ T cell exhaustion and tumor development in ESCC through SMARCD1-mediated CCL8 secretion and lactate efflux.
    Journal
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    CD8 (cluster of differentiation 8) • CCL8 (C-C Motif Chemokine Ligand 8) • BCL11B (BAF Chromatin Remodeling Complex Subunit BCL11B) • SLC16A3 (Solute Carrier Family 16 Member 3) • SMARCD1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily D, Member 1) • CBX6 (Chromobox 6)
    5ms
    LDB1::KMT2A Fusion in a Spindle-Cell Sarcoma: A Case Report. (PubMed, Genes Chromosomes Cancer)
    The patient underwent wide surgical excision and remains disease-free at a 5-month follow-up. This report presents the first known case of an LDB1::KMT2A fusion in a spindle-cell sarcoma, expanding the molecular spectrum of the emerging entity of KMT2A-rearranged sarcomas.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • CCND1 (Cyclin D1) • KMT2A (Lysine Methyltransferase 2A) • WT1 (WT1 Transcription Factor) • BCOR (BCL6 Corepressor) • YAP1 (Yes associated protein 1) • CD34 (CD34 molecule) • SOX10 (SRY-Box 10) • VIM (Vimentin) • MUC4 (Mucin 4, Cell Surface Associated) • STAT6 (Signal transducer and activator of transcription 6) • CD99 (CD99 Molecule) • SS18 (SS18 Subunit Of BAF Chromatin Remodeling Complex) • MYOD1 (Myogenic Differentiation 1) • CBX6 (Chromobox 6)
    1year
    Targeting UBE2T suppresses breast cancer stemness through CBX6-mediated transcriptional repression of SOX2 and NANOG. (PubMed, Cancer Lett)
    The pharmacological inhibitor of UBE2T significantly reduced the expression of NANOG and SOX2, suppressed tumor progression, and demonstrated synergistic effects when combined with chemotherapeutics, but not with other treatments. Collectively, our study revealed that the UBE2T-TRIM25-CBX6 axis can regulate BCSC stemness and offers a potentially therapeutic strategy to combat breast cancer in a clinical translation setting.
    Journal
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    SOX2 • NANOG (Nanog Homeobox) • CBX6 (Chromobox 6)
    over1year
    CBX7 promotes choroidal neovascularization by activating the HIF-1α/VEGF pathway in choroidal vascular endothelial cells. (PubMed, Exp Eye Res)
    Mouse CNV was lessened by the blockade of CBX7 through the down-regulation of HIF-1α/VEGF. In conclusion, CBX7 enhanced pro-angiogenic behaviors of hypoxic CVECs by up-regulating the HIF-1α/VEGF pathway, which contributing to the formation of mouse laser-induced CNV.
    Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • CBX2 (Chromobox 2) • CBX6 (Chromobox 6) • CBX8 (Chromobox 8)
    almost2years
    The predictive significance of chromobox family members in prostate cancer in humans. (PubMed, Cell Oncol (Dordr))
    CBX2 is involved in the development and advancement of PCa, suggesting its potential as a reliable prognostic indicator for PCa patients.
    Journal
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    FOXP3 (Forkhead Box P3) • CBX2 (Chromobox 2) • CBX3 (Chromobox 3) • CBX6 (Chromobox 6) • CBX8 (Chromobox 8)
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    FOXP3 expression
    almost2years
    How CBX proteins regulate normal and leukemic blood cells. (PubMed, FEBS Lett)
    To target, reprogram, and kill leukemic cells, we suggest and describe multiple therapeutic strategies to interfere with the epigenetic functions of oncogenic CBX proteins. Future studies should clarify to what extent the non-epigenetic function of cytoplasmic CBX proteins is important for normal, aged, and leukemic blood cells.
    Review • Journal
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    CBX2 (Chromobox 2) • CBX6 (Chromobox 6) • CBX8 (Chromobox 8)
    2years
    KMT2A-rearranged sarcoma with unusual fusion gene CBX6::KMT2A::PYGO1. (PubMed, Virchows Arch)
    Although highly likely irreproducible, tumors with the CBX6::KMT2A::PYGO1 fusion gene were morphologically somewhat different from those containing the YAP1::KMT2A::YAP1. This suggests that KMT2A rearrangements with fusion gene partners different from YAP1 result in purely spindle-shaped cell tumors that produce collagen fibers.
    Journal
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    KMT2A (Lysine Methyltransferase 2A) • YAP1 (Yes associated protein 1) • CBX6 (Chromobox 6)
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    KMT2A rearrangement • MLL rearrangement
    over2years
    Bladder cancer course, four genetic high-risk variants, and histopathological findings. (PubMed, EXCLI J)
    Also, no significant differences in the bladder cancer subgroups of MIBC and NMIBC were observed. The 4 investigated SNPs do not noticeably contribute differently to the bladder cancer risk for the bladder cancer subgroups of MIBC and NMIBC.
    Journal
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    FGFR3 (Fibroblast growth factor receptor 3) • TACC3 (Transforming acidic coiled-coil containing protein 3) • APOB (Apolipoprotein B) • APOBEC3A (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3A) • PSCA (Prostate Stem Cell Antigen 2) • CBX6 (Chromobox 6)
    over2years
    SOCS1 as a Biomarker Candidate for HPV Infection and Prognosis of Head and Neck Squamous Cell Carcinomas. (PubMed, Curr Issues Mol Biol)
    This study provides new information on biological targets that may be relevant to the molecular mechanisms underpinning the occurrence and development of HNSCC. SOCS1 may play an important role in the interaction between HPV and HNSCC and serve as a potential biomarker for future therapeutic targets.
    Journal
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    ERBB4 (erb-b2 receptor tyrosine kinase 4) • EREG (Epiregulin) • SOCS1 (Suppressor Of Cytokine Signaling 1) • NFKBIA (NFKB Inhibitor Alpha 2) • CBX6 (Chromobox 6)
    over2years
    Gene biomarkers and classifiers for various subtypes of HTLV-1-caused ATLL cancer identified by a combination of differential gene co‑expression and support vector machine algorithms. (PubMed, Med Microbiol Immunol)
    These genes also can classify each ATLL subtype from AC carriers. The integration of the results of two powerful algorithms led to the identification of reliable gene classifiers and biomarkers for diverse ATLL subtypes.
    Journal
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    CBX6 (Chromobox 6)