^
Contact us  to learn more about
our Premium Content:  News alerts, weekly reports and conference planners
DRUG:

CBT-1 (tetrandrine)

i
Associations
Trials
Company:
CBA Pharma
Drug class:
P-glycoprotein inhibitor, Ca2+ channel antagonist, MDR modulator
Associations
Trials
17d
Tetrandrine augments melanoma cell immunogenicity via dual inhibition of autophagic flux and proteasomal activity enhancing MHC-I presentation. (PubMed, Acta Pharmacol Sin)
These results highlight tetrandrine's unique mechanism of action in enhancing MHC-I-mediated antigen presentation through dual inhibition of autophagic flux and proteasomal degradation. This study underscores tetrandrine's potential as a novel immunomodulatory agent to boost CD8+ T cell-mediated tumor cell eradication and enhance the efficacy of immune checkpoint therapies.
Journal • PD(L)-1 Biomarker • IO biomarker
|
CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma)
|
CBT-1 (tetrandrine)
19d
TAX1BP1-dependent autophagic degradation of STING1 impairs anti-tumor immunity. (PubMed, Autophagy)
The antitumor immunity mediated by tetrandrine and STING1 agonists is limited by neutralizing antibodies to the type I interferon receptor or CD8+ T cells. Thus, these findings establish a potential immunotherapeutic strategy against pancreatic cancer by preventing the autophagic degradation of STING1.
Journal • IO biomarker
|
CD8 (cluster of differentiation 8) • STING (stimulator of interferon response cGAMP interactor 1) • IFNAR2 (Interferon Alpha And Beta Receptor Subunit 2)
|
CBT-1 (tetrandrine)
24d
Tetrandrine induces cell cycle arrest in cutaneous melanoma cells by inhibiting IL-6/CDC42 signaling. (PubMed, Arch Dermatol Res)
Tetrandrine suppressed CM cell growth by triggering G0/G1 cell cycle arrest via IL-6/CDC42 inhibition. Tetrandrine should be a promising compound for CM treatment.
Journal
|
CCND1 (Cyclin D1) • IL6 (Interleukin 6) • CDC42 (Cell Division Cycle 42)
|
CBT-1 (tetrandrine)
1m
Tetrandrine alleviates macrophage activation syndrome after CAR-T cell therapy. (PubMed, Phytomedicine)
This study identified tetrandrine as a promising therapeutic candidate for attenuating macrophage activation associated with CAR-T cell therapy and LPS/Poly I:C-induced stimulation. These findings underscore the potential of tetrandrine to mitigate toxicities after CAR-T cell therapy while ensuring its therapeutic efficacy.
Journal
|
IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • IL2 (Interleukin 2) • CSF2 (Colony stimulating factor 2) • IL1B (Interleukin 1, beta)
|
CBT-1 (tetrandrine)
2ms
Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy. (PubMed, J Pharm Anal)
This study highlights the potential of TET as an antimelanoma agent that targets SIRT5. These findings provide a promising avenue for the use of TET in melanoma treatment and underscore its potential as a therapeutic candidate.
Journal
|
ATF6 (Activating Transcription Factor 6) • SIRT5 (Sirtuin 5)
|
CBT-1 (tetrandrine)
2ms
CAMKIIδ Reinforces Lipid Metabolism and Promotes the Development of B Cell Lymphoma. (PubMed, Adv Sci (Weinh))
This study also evaluates Tetrandrine (TET), a small molecule compound, as a potent CAMKIIδ inhibitor...Collectively, this study highlights how CAMKIIδ is critical in BCL progression. The results also pave the way for innovative therapeutic strategies for treating aggressive BCL.
Journal
|
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • IRF4 (Interferon regulatory factor 4) • CAMK2D (Calcium/Calmodulin Dependent Protein Kinase II Delta)
|
CBT-1 (tetrandrine)
6ms
Tetrandrine Tablets Used in Hospitalized Adults With COVID-19 (clinicaltrials.gov)
P4, N=0, Withdrawn, Peking University Third Hospital | N=414 --> 0 | Not yet recruiting --> Withdrawn
Enrollment change • Trial withdrawal
|
CBT-1 (tetrandrine)
8ms
Tetrandrine Activates STING/TBK1/IRF3 Pathway to Potentiate Anti-PD-1 Immunotherapy Efficacy in Non-Small Cell Lung Cancer. (PubMed, Pharmacol Res)
We further revealed that the combination of TET with αPD-1 monoclonal antibody (αPD-1 mAb) yields significant anti-cancer effects by promoting CD8+ T cell infiltration and enhancing its cell-killing effect, which in turn reduced the growth of tumors and prolonged survival of NSCLC mice. Therefore, TET effectively eliminates NSCLC cells and enhances immunotherapy efficacy through the activation of the STING pathway, and combining TET with anti-PD-1 immunotherapy deserves further exploration for applications.
Journal
|
STING (stimulator of interferon response cGAMP interactor 1)
|
CBT-1 (tetrandrine)
8ms
Inhibition of autophagy induced by tetrandrine promotes the accumulation of reactive oxygen species and sensitizes efficacy of tetrandrine in pancreatic cancer. (PubMed, Cancer Cell Int)
The results of treating subcutaneous xenograft tumors with a combination of tetrandrine and chloroquine validated that autophagy inhibition enhances the toxicity of tetrandrine against pancreatic cancer in vivo. Altogether, our study demonstrates that tetrandrine induces cytoprotective autophagy in pancreatic cancer cells. Inhibiting tetrandrine-induced autophagy promotes the accumulation of ROS and enhances its toxicity against pancreatic cancer.
Journal • IO biomarker
|
BCL2 (B-cell CLL/lymphoma 2) • ATG7 (Autophagy Related 7) • BECN1 (Beclin 1)
|
CBT-1 (tetrandrine) • chloroquine phosphate
11ms
Bioinformatics and system biology approaches to determine the connection of SARS-CoV-2 infection and intrahepatic cholangiocarcinoma. (PubMed, PLoS One)
This study is expected to provide valuable references and potential drugs for future research and treatment of COVID-19 and ICC.
Journal
|
ALDOA (Aldolase Fructose-Bisphosphate A) • ACSL5 (Acyl-CoA Synthetase Long Chain Family Member 5) • ACADSB (Acyl-CoA Dehydrogenase Short/Branched Chain)
|
CBT-1 (tetrandrine)
1year
Study on the Effect and Mechanism of Tetrandrine on Bone Marrow Mesenchymal Stem Cell-Mediated Drug Resistance in Leukemia (PubMed, Zhongguo Shi Yan Xue Ye Xue Za Zhi)
BMSC can promote the drug resistance of leukemia cells, and TET may reverse the BMSC-mediated drug resistance via inhibiting IL-6/STAT3 signaling pathway.
Journal
|
IL6 (Interleukin 6) • IL2 (Interleukin 2) • IL10 (Interleukin 10)
|
IL2 expression • IL6 expression
|
daunorubicin • CBT-1 (tetrandrine)
1year
Protective effect of Tetrandrine on optic nerve by inhibiting glial activation through NF-κB pathway. (PubMed, Heliyon)
Moreover, LPS activate NF-κB signal pathway, while Tet efficiently inhibited this effect.Furthermore, injection of Tet did not damage theroutineblood, liver and kidney. Retrobulbar injection of Tet significantly alleviatedLPS-induced uveitisand optic nerve injuryof rats by activating gliocyte and NF-κB signaling pathway.
Journal
|
IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • IL2 (Interleukin 2)
|
CBT-1 (tetrandrine)
1year
New perspectives on the potential of tetrandrine in the treatment of non-small cell lung cancer: bioinformatics, Mendelian randomization study and experimental investigation. (PubMed, Aging (Albany NY))
Subsequent single-cell sequencing data confirmed that these four genes were distributed in epithelial cells, and SMR analysis revealed the causal relationship between CCNA2 and CCNB1 and the development of NSCLC. The final molecular docking and drug experiments showed that CCNA2 and CCNB1 are key targets for tetrandrine in the treatment of NSCLC.
Journal
|
CCNA2 (Cyclin A2) • CCNB1 (Cyclin B1)
|
CBT-1 (tetrandrine)
over1year
Dissection of the antitumor mechanism of tetrandrine based on metabolite profiling and network pharmacology. (PubMed, Rapid Commun Mass Spectrom)
The metabolism features of tetrandrine and its potential antitumor mechanism were summarized, providing data for further pharmacological validation.
Journal
|
AKT1 (V-akt murine thymoma viral oncogene homolog 1) • MMP2 (Matrix metallopeptidase 2) • MMP9 (Matrix metallopeptidase 9)
|
CBT-1 (tetrandrine)
over1year
Tetrandrine synergizes with MAPK inhibitors in treating KRAS-mutant pancreatic ductal adenocarcinoma via collaboratively modulating the TRAIL-death receptor axis. (PubMed, Pharmacol Res)
Of great interest, tetrandrine stabilizes DR4/DR5 protein via impairing ubiquitination-mediated protein degradation, thereby allowing a synergy with MAPK inhibition in inducing apoptosis in KRAS-mutant PDAC. Our findings identify a new combinatorial approach for treating KRAS-mutant PDAC and highlight the role of TRAIL-DR4/DR5 axis in dictating the therapeutic outcome in KRAS-mutant PDAC.
Journal
|
KRAS (KRAS proto-oncogene GTPase)
|
KRAS mutation
|
Koselugo (selumetinib) • ulixertinib (BVD-523) • hydroxychloroquine • MG132 • CBT-1 (tetrandrine) • ravoxertinib (RG7842)
over1year
Tetrandrine Tablets Used in Hospitalized Adults With COVID-19 (clinicaltrials.gov)
P4, N=414, Not yet recruiting, Peking University Third Hospital | Trial completion date: Dec 2024 --> Dec 2025 | Initiation date: Jan 2023 --> Dec 2023 | Trial primary completion date: Dec 2024 --> Dec 2025
Trial completion date • Trial initiation date • Trial primary completion date
|
CBT-1 (tetrandrine)
over1year
A (Traditional Chinese Medicine) TCM-Inspired Doxorubicin Resistance Reversing Strategy: Preparation, Characterization, and Application of a Co-loaded pH-Sensitive Liposome. (PubMed, AAPS PharmSciTech)
Dihydroartemisinin (DHA) and tetrandrine (TET) were co-delivered for the first time to treat DOX resistance of breast cancer with multi-pathway mechanism. With the DOX resistance reversing ability increased, the inhibition effect of DHA-TET pH-sensitive LPs on both MCF-7/ADR cells and MCF-7 cells was significantly enhanced; meanwhile, the toxicity on cardiac cell (H9c2) was lowered. Ferroptosis induced by the DHA was investigated showing that the intracellular reactive oxygen species (ROS) and lipid peroxidation were increased to promote the synergistic effect through the due-loaded nano-carrier, providing a promising alternative for future clinical application.
Journal
|
doxorubicin hydrochloride • CBT-1 (tetrandrine)
over1year
miR-638 suppresses cervical cancer progression by inhibiting NCAPG2 under the treatment of Tetrandrine. (PubMed, Histol Histopathol)
We highlighted that miR-638 suppresses cervical cancer progression by inhibiting NCAPG2 under tetrandrine treatment.
Journal
|
MIR638 (MicroRNA 638) • CAPG (Capping Actin Protein, Gelsolin Like) • NCAPG2 (Non-SMC Condensin II Complex Subunit G2)
|
CBT-1 (tetrandrine)
almost2years
Tetrandrine citrate suppresses lung adenocarcinoma growth via SLC7A11/GPX4-mediated ferroptosis. (PubMed, Discov Oncol)
Finally, in our vivo experiment, we discovered that TetC significantly slowed the growth rate of subcutaneous transplanted A549 cells, ultimately proving to be biosafe. In conclusion, our study first identified the mechanism by which TetC-induced ferroptosis in LUAD via SLC7A11/GPX4 signaling.
Journal
|
GPX4 (Glutathione Peroxidase 4) • SLC7A11 (Solute Carrier Family 7 Member 11)
|
SLC7A11 expression
|
CBT-1 (tetrandrine)
almost2years
Blocking autophagy by the two-pore channels antagonist tetrandrine improves sorafenib-induced death of hepatocellular carcinoma cells. (PubMed, Toxicol In Vitro)
Therefore, our study proposes the use of tetrandrine analogs with the aim of improving sorafenib therapy. Also, our data also allow us to suggest that TPCs may be a new target in anticancer therapies.
Journal
|
sorafenib • CBT-1 (tetrandrine)
almost2years
FLI1 Regulates Histamine Decarboxylase Expression to Control Inflammation Signaling and Leukemia Progression. (PubMed, J Inflamm Res)
Indeed, diacerein, an IL1B inhibitor, strongly blocked Fli-1-induced leukemia in mice. Moreover, the HDC inhibitor, tetrandrine, suppressed HDC transcription by directly binding to and inhibiting the FLI1 DNA binding domain, and like other FLI1 inhibitors, tetrandrine strongly suppressed cell proliferation in culture and leukemia progression in vivo. These results suggest a role for the transcription factor FLI1 in inflammation signaling and leukemia progression through HDC and point to the HDC pathway as potential therapeutics for FLI1-driven leukemia.
Journal
|
FLI1 (Fli-1 Proto-Oncogene ETS Transcription Factor) • GATA2 (GATA Binding Protein 2) • CPA3 (Carboxypeptidase A3) • CXCR2 (Chemokine (C-X-C motif) receptor 2) • IL1B (Interleukin 1, beta)
|
CBT-1 (tetrandrine)
almost2years
Study on the mechanism of oral administration of tetrandrine during neoadjuvant chemotherapy for colon cancer. (PubMed, Oncol Lett)
During chemotherapy of patients with colon cancer, tetrandrine may inhibit the expression of TNF-α in cancer tissues and blood, reduce the release of inflammatory factors and chemokines and decrease cancer cell proliferation. These findings provide a theoretical basis for the treatment of colon cancer in the clinic.
Journal
|
IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • CCL20 (C-C Motif Chemokine Ligand 20) • CCL2 (Chemokine (C-C motif) ligand 2) • CXCL5 (Chemokine (C-X-C motif) ligand 5) • IL15 (Interleukin 15) • IL1B (Interleukin 1, beta) • CXCL1 (Chemokine (C-X-C motif) ligand 1) • CXCL3 (C-X-C Motif Chemokine Ligand 3)
|
IL6 expression
|
CBT-1 (tetrandrine)
almost2years
Total alkaloids in Stephania tetrandra induce apoptosis by regulating BBC3 in human non-small cell lung cancer cells. (PubMed, Biomed Pharmacother)
TAS and the main alkaloid components exert anticancer activity in NSCLC by regulating tumor cell proliferation and apoptosis. Therefore, TAS and the main alkaloid components have the potential to be used as multi-targeted drugs for lung cancer treatment.
Journal
|
BBC3 (BCL2 Binding Component 3) • MGLL (Monoglyceride Lipase)
|
cisplatin • CBT-1 (tetrandrine)
almost2years
Tetrandrine Inhibits Cancer Stem Cell Characteristics and Epithelial to Mesenchymal Transition in Triple-Negative Breast Cancer via SOD1/ROS Signaling Pathway. (PubMed, Am J Chin Med)
The results of this study suggest that tetrandrine could effectively inhibit breast cancer stem cell characteristics and the EMT process via the SOD1/ROS signaling pathway. Therefore, tetrandrine can be considered a promising anti-TNBC agent.
Journal • Cancer stem
|
CDH1 (Cadherin 1) • CD24 (CD24 Molecule) • VIM (Vimentin) • CAT (Catalase) • OCLN (Occludin) • SOD1 (Superoxide Dismutase 1)
|
CDH1 expression
|
CBT-1 (tetrandrine)
2years
Tetrandrine inhibits migration and invasion of BGC-823 and MKN-45 cells by regulating PI3K/AKT/mTOR signaling pathway. (PubMed, Chem Biol Drug Des)
In animal experiments, tumor growth was inhibited by Tet administration in a dose-dependent manner. In conclusion, the current data indicated that Tet had a critical effect on inhibiting BGC-823 and MKN-45 cells proliferation, migration, invasion and tumor growth via regulating PI3K/AKT/mTOR signaling pathway, suggesting that Tet might be a potential treatment for GC.
Journal
|
MMP2 (Matrix metallopeptidase 2) • CDH2 (Cadherin 2) • MMP9 (Matrix metallopeptidase 9) • PCNA (Proliferating cell nuclear antigen)
|
PCNA expression
|
CBT-1 (tetrandrine)
2years
Phytochemicals and mitochondria: Therapeutic allies against gastric cancer. (PubMed, Phytomedicine)
Phytochemicals could target the mitochondria in the treatment of gastric cancer, providing potential directions and evidence for clinical translation. Drug discovery focused on phytochemicals has great potential to break barriers in cancer treatment.
Review • Journal
|
BCL2 (B-cell CLL/lymphoma 2)
|
CBT-1 (tetrandrine)
over2years
Study on the molecular mechanisms of tetrandrine against pulmonary fibrosis based on network pharmacology, molecular docking and experimental verification. (PubMed, Heliyon)
TGF-β1-induced human lung adenocarcinoma A549 cells were used as an in vitro experimental verification model, taking dexamethasone (Dex) as the positive control, to verify the effects of Tet on the mRNA expression of the candidate targets. Combined with the results of theoretical calculation and experimental verification, and considering the roles of these targets in the pathogenesis of PF, Tet might antagonize PF by acting on PDPK1 and RAC1. The results of this study will provide scientific reference for the prevention and clinical diagnosis and treatment of PF.
Journal
|
PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • KDR (Kinase insert domain receptor) • RAC1 (Rac Family Small GTPase 1) • RPS6KB1 (Ribosomal Protein S6 Kinase B1) • TGFB1 (Transforming Growth Factor Beta 1) • PDPK1 (3-Phosphoinositide dependent protein kinase 1)
|
dexamethasone • CBT-1 (tetrandrine)
over2years
Design, Synthesis, and Biological Evaluation of N14-Amino Acid-Substituted Tetrandrine Derivatives as Potential Antitumor Agents against Human Colorectal Cancer. (PubMed, Molecules)
Further study showed that 16 effectively inhibited the proliferation, migration, and tube formation of umbilical vein endothelial cells, manifesting in a potent anti-angiogenesis effect. Overall, these results revealed the potential of 16 as a promising candidate for further preclinical studies.
Journal
|
SQSTM1 (Sequestosome 1) • BECN1 (Beclin 1)
|
CBT-1 (tetrandrine)
over2years
Growth-Suppressive and Apoptosis-Inducing Effects of Tetrandrine in SW872 Human Malignant Liposarcoma Cells via Activation of Caspase-9, Down-Regulation of XIAP and STAT-3, and ER Stress. (PubMed, Biomolecules)
Tetrandrine also had abilities to up-regulate not only the expression of GRP78 and ATF-4 but also the phosphorylation of eIF-2α in SW872 cells. In summary, these results demonstrated that tetrandrine has strong growth-suppressive and apoptosis-inducing effects on SW872 cells, which are mediated through control of the intrinsic caspase pathway, down-regulation of XIAP and STAT-3, and triggering ER stress.
Journal
|
STAT3 (Signal Transducer And Activator Of Transcription 3) • CASP9 (Caspase 9) • HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • XIAP (X-Linked Inhibitor Of Apoptosis) • ATF4 (Activating Transcription Factor 4)
|
CBT-1 (tetrandrine)
almost3years
Tetrandrine Citrate Suppresses Breast Cancer via Depletion of Glutathione Peroxidase 4 and Activation of Nuclear Receptor Coactivator 4-Mediated Ferritinophagy. (PubMed, Front Pharmacol)
Further studies showed that TetC significantly suppressed the expression of glutathione peroxidase 4 (GPX4) and ferritin heavy chain 1 (FTH1) but increased the expression of nuclear receptor coactivator 4 (NCOA4) in MCF7 and MDA-MB-231 cells even in the presence of erastin or Ras-selective lethal 3 (RSL3). Collectively, we showed novel data that ferroptosis was a major form of TetC-induced cell death. Moreover, TetC-induced ferroptotic cell death was achieved via suppressing GPX4 expression and activating NCOA4-mediated ferritinophagy in BC cells.
Journal
|
NCOA4 (Nuclear Receptor Coactivator 4) • GPX4 (Glutathione Peroxidase 4) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)
|
GPX4 expression
|
erastin • RSL3 • CBT-1 (tetrandrine)
almost3years
Plant Alkaloid Tetrandrine Is a Nuclear Receptor 4A1 Antagonist and Inhibits Panc-1 Cell Growth In Vitro and In Vivo. (PubMed, Int J Mol Sci)
Furthermore, at a dose of 25 mg/kg/day, TTD reduced tumor growth in an athymic nude mouse xenograft model bearing Panc-1 cells. These data show that TTD is an NR4A1 antagonist and that modulation of the NR4A1-mediated pro-survival pathways is involved in the antitumor effects of TTD.
Preclinical • Journal
|
BIRC5 (Baculoviral IAP repeat containing 5)
|
CBT-1 (tetrandrine)
3years
Tetrandrine Suppresses Human Brain Glioblastoma GBM 8401/luc2 Cell-Xenografted Subcutaneous Tumors in Nude Mice In Vivo. (PubMed, Molecules)
Furthermore, the hematoxylin and eosin (H & E) staining of kidney, liver, and spleen tissues showed no significant difference between the TET-treated and control groups. Overall, these observations demonstrated that TET suppressed subcutaneous tumor growth in a nude-mice model via the induction of cell apoptosis.
Preclinical • Journal
|
CASP3 (Caspase 3) • CASP8 (Caspase 8) • XIAP (X-Linked Inhibitor Of Apoptosis) • CFLAR (CASP8 and FADD-like apoptosis regulator)
|
CBT-1 (tetrandrine)
3years
Screening of drugs that selectively inhibit uveal melanoma cells with SF3B1 mutations (PubMed, Nan Fang Yi Ke Da Xue Xue Bao)
This study provides a cell screening model for identification of potential individualized treatment drugs for patients with uveal melanoma with SF3B1 mutation.
Preclinical • Journal
|
SF3B1 (Splicing Factor 3b Subunit 1)
|
SF3B1 mutation
|
lapatinib • CBT-1 (tetrandrine)
3years
Effects of tetrandrine on proliferation, migration, and invasion of glioblastoma cells (PubMed, Zhongguo Zhong Yao Za Zhi)
The plate cloning assay and soft agar colony formation assay showed that Tet weakened the colony formation of LN229 cells in vitro; cytometry assay showed that Tet blocked cells in the G_1 phase and promoted cell apoptosis; scratch and Transwell assays proved that Tet inhibited the migration and invasion of LN229 cells; Western blot results showed that Tet down-regulated the expression levels of CDK2, CDK6, cyclin D1, cyclin E1, snail, slug, vimentin, and N-cadherin, while up-regulated the level of E-cadherin. The results indicate that Tet has a certain inhibitory effect on the proliferation, migration, and invasion of LN229 glioblastoma cells, and such effect may be related to the participation of Tet in the regulation of c-Myc/p27 axis and snail signaling pathway.
Journal
|
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CCND1 (Cyclin D1) • CCNE1 (Cyclin E1) • CDH1 (Cadherin 1) • CDK6 (Cyclin-dependent kinase 6) • VIM (Vimentin) • CDK2 (Cyclin-dependent kinase 2) • SNAI2 (Snail Family Transcriptional Repressor 2)
|
CCND1 expression • CDK2 expression • CDK6 expression
|
CBT-1 (tetrandrine)
over3years
Personalised Medicine for Colorectal Cancer Using Mechanism-Based Machine Learning Models. (PubMed, Int J Mol Sci)
Several significant genes that should be integrated into future mechanistic models of the WNT pathway are DVL3, FZD5, RAC1, ROCK2, GSK3B, CTB2, CBT1, and PRKCA. Thus, the study demonstrates that using mechanistic information in combination with machine learning can identify novel features (genes and proteins) that are important for explaining the STN heterogeneity between patients and their association to clinical outcomes.
Journal
|
RAC1 (Rac Family Small GTPase 1) • PRKCA (Protein Kinase C Alpha)
|
CBT-1 (tetrandrine)
over3years
Tetrandrine suppresses the growth of human osteosarcoma cells by regulating multiple signaling pathways. (PubMed, Bioengineered)
Furthermore, the regulatory effect of TET on OS cells and related signaling pathways was verified again in vivo. Our findings suggest that the anticancer function of TET on human OS may be mediated by its targeting of multiple signaling pathways and that TET may be used as a single drug or in combination with other drugs during the treatment of OS.
Journal
|
PTEN (Phosphatase and tensin homolog)
|
CBT-1 (tetrandrine)
over3years
Tetrandrine Inhibits Epithelial-Mesenchymal Transition in IL-6-Induced HCT116 Human Colorectal Cancer Cells. (PubMed, Onco Targets Ther)
In addition, tetrandrine restored E-cadherin gene promoter activity. The findings of the present study suggested that tetrandrine may inhibit EMT in IL-6-stimulated HCT116 cells; therefore, it may represent a potential drug for CRC.
Journal
|
IL6 (Interleukin 6) • CDH1 (Cadherin 1) • MMP2 (Matrix metallopeptidase 2)
|
CDH1 expression
|
CBT-1 (tetrandrine)
over3years
The enhancement of Tetrandrine to gemcitabine-resistant PANC-1 cytochemical sensitivity involves the promotion of PI3K/Akt/mTOR-mediated apoptosis and AMPK-regulated autophagy. (PubMed, Acta Histochem)
TET promotes apoptosis by inhibiting the PI3K/Akt/mTOR signaling pathway and promotes autophagy via up-regulating the AMPK signaling pathway to play an anti-tumor effect in GEM-resistant pancreatic cancer cells, which represents a new therapeutic strategy for the treatment of GEM-resistant pancreatic cancer.
Journal
|
BIRC5 (Baculoviral IAP repeat containing 5) • AMPK (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1)
|
BIRC5 expression
|
gemcitabine • CBT-1 (tetrandrine)
over3years
Mechanism of Tetrandrine Against Endometrial Cancer Based on Network Pharmacology. (PubMed, Drug Des Devel Ther)
The results were further confirmed by immunofluorescence assays. Based on bioinformatic analysis and experimental verification, our findings demonstrated that tetrandrine exerted tumour-suppressive effects on EC by regulating the PI3K/Akt signalling pathway.
Journal • IO biomarker
|
BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein)
|
BCL2 expression • BAX expression
|
CBT-1 (tetrandrine)
4years
Resuming Sensitivity of Tamoxifen-Resistant Breast Cancer Cells to Tamoxifen by Tetrandrine. (PubMed, Integr Cancer Ther)
Tet as a monotherapy inhibits TAM-R cells. Tet potentiates the pro-apoptotic effect of TAM via inhibition of autophagy.
Journal
|
TP53 (Tumor protein P53)
|
tamoxifen • CBT-1 (tetrandrine)